Photo of S. J. Adelstein,  MD, PhD

S. J. Adelstein, MD, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 432-3997
Fax: (617) 432-0173


james_adelstein@hms.harvard.edu

S. J. Adelstein, MD, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Paul C. Cabot Distinguished Professor of Medical Biophysics, Radiology, Harvard Medical School
  • Professor, Nuclear Medicine, Harvard Medical School
  • Senior Radiologist, Nuclear Medicine, Brigham And Women's Hospital

Research Abstract

Our laboratory studies the biophysical effects of densely ionizing radiation and its application to experimental cancer therapy. The interaction of alpha particles as well as Auger and Koster-Cronig electrons wtih chromosal DNA and its consituents is a central focus. Biological endpoints include double strand breaks, clonal survival, transformation and mutagenesis. The information obtained from these studies is used in the development of agents for targeted radionuclide therapy.We are also interested in cell surface enzymes and mitochondrial membranes as targets for radio-labeled imaging and therapeutic probes.

Publications

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  • Adelstein SJ. Radiation risk in nuclear medicine. Semin Nucl Med 2014; 44:187-92. PubMed
  • Mamlouk O, Balagurumoorthy P, Wang K, Adelstein SJ, Kassis AI. Bystander effect in tumor cells produced by Iodine-125 labeled human lymphocytes. Int J Radiat Biol 2012. PubMed
  • Yang Y, Adelstein SJ, Kassis AI. General approach to identifying potential targets for cancer imaging by integrated bioinformatics analysis of publicly available genomic profiles. Mol Imaging 2011; 10:123-34. PubMed
  • Hricak H, Brenner DJ, Adelstein SJ, Frush DP, Hall EJ, Howell RW, McCollough CH, Mettler FA, Pearce MS, Suleiman OH, Thrall JH, Wagner LK. Managing radiation use in medical imaging: a multifaceted challenge. Radiology 2011; 258:889-905. PubMed
  • Yang Y, Adelstein SJ, Kassis AI. Integrated bioinformatics analysis for cancer target identification. Methods Mol Biol 2011; 719:527-45. PubMed
  • Yang S Y, Adelstein J, Kassis AI. Putative molecular signatures for the imaging of prostate cancer. Expert Rev Mol Diagn 2009; 10:65-74. PubMed
  • Singh A,Yang Y,Adelstein SJ,Kassis AI. Synthesis and application of molecular probe for detection of hydroxyl radicals produced by Na(125)I and gamma-rays in aqueous solution. Int J Radiat Biol 2008; 84:1001-10. PubMed
  • Balagurumoorthy P,Wang K,Adelstein SJ,Kassis AI. DNA double-strand breaks induced by decay of (123)I-labeled Hoechst 33342: role of DNA topology. Int J Radiat Biol 2008; 84:976-83. PubMed
  • Howell RW,Martin RF,Nikjoo H,Pomplun E,Terrissol M,Watanable R,Yasui L,Kassis AI,Adelstein SJ. Meeting overview. Int J Radiat Biol 2008; 84:957-8. PubMed
  • Balagurumoorthy P,Adelstein SJ,Kassis AI. Method to eliminate linear DNA from mixture containing nicked circular, supercoiled, and linear plasmid DNA. Anal Biochem 2008; 381:172-4. PubMed
  • Balagurumoorthy P,Chen K,Adelstein SJ,Kassis AI. Auger electron-induced double-strand breaks depend on DNA topology. Radiat Res 2008; 170:70-82. PubMed
  • Wang K, Adelstein SJ, Kassis AI. DMSO increases radioiodination yield of radiopharmaceuticals. Appl Radiat Isot 2007; 66:50-9. PubMed
  • Wong RC, Favaloro EJ, Adelstein S, Baumgart K, Bird R, Brighton TA, Empson M, Gillis D, Hendle MJ, Laurent R, Mallon D, Pollock W, Smith S, Steele RH, Wilson RJ. Consensus guidelines on anti-beta 2 glycoprotein I testing and reporting. Pathology 2007; 40:58-63. PubMed
  • Kassis AI, Korideck H, Wang K, Pospisil P, Adelstein SJ. Novel prodrugs for targeting diagnostic and therapeutic radionuclides to solid tumors. Molecules 2008; 13:391-404. PubMed
  • Wang K, Kirichian AM, Aowad AF, Adelstein SJ, Kassis AI. Evaluation of chemical, physical, and biologic properties of tumor-targeting radioiodinated quinazolinone derivative. Bioconjug Chem 2007; 18:754-64. PubMed
  • Pospisil P, Wang K, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI. Computational modeling and experimental evaluation of a novel prodrug for targeting the extracellular space of prostate tumors. Cancer Res 2007; 67:2197-205. PubMed
  • Chen K, Aowad AF, Adelstein SJ, Kassis AI. Molecular-docking-guided design, synthesis, and biologic evaluation of radioiodinated quinazolinone prodrugs. J Med Chem 2007; 50:663-73. PubMed
  • Chen K, Wang K, Kirichian AM, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI. In silico design, synthesis, and biological evaluation of radioiodinated quinazolinone derivatives for alkaline phosphatase-mediated cancer diagnosis and therapy. Mol Cancer Ther 2006; 5:3001-13. PubMed
  • Urashima T, Nagasawa H, Wang K, Adelstein SJ, Little JB, Kassis AI. Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with gamma-ray exposure. Nucl Med Biol 2006; 33:1055-63. PubMed
  • Balagurumoorthy P, Chen K, Bash RC, Adelstein SJ, Kassis AI. Mechanisms underlying production of double-strand breaks in plasmid DNA after decay of 125I-Hoechst. Radiat Res 2006; 166:333-44. PubMed
  • Pospisil P, Iyer LK, Adelstein SJ, Kassis AI. A combined approach to data mining of textual and structured data to identify cancer-related targets. BMC Bioinformatics 2006; 7:354. PubMed
  • Kishikawa H, Wang K, Adelstein SJ, Kassis AI. Inhibitory and stimulatory bystander effects are differentially induced by Iodine-125 and Iodine-123. Radiat Res 2006; 165:688-94. PubMed
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