S. N. Goldberg, MD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 667-4510
Fax: (617) 667-8212


sgoldber@bidmc.harvard.edu

S. N. Goldberg, MD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Lecturer, Radiology, Harvard Medical School
  • Director, CT Intervention and Tumor Ablation Therapy, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

The primary goal of my research focus is to develop image-guided, minimally invasive therapies for malignant disease with radiofrequency (RF) tissue ablation, a thermally-mediated method for inducing coagulation necrosis serving as the key core-enabling technology. A main focus of our investigation has been the use of RF ablation as a treatment for liver and other focal metastases. Over the last five years, we have extensively characterized the relationship between RF parameters and the resultant induced coagulation necrosis. In addition, we have reported several technical advances which have sequentially increased the achievable coagulation diameter from a single RF application to greater than 7 cm including: the use of multiprobe arrays, saline infusion, internally-cooled electrodes, pulsed-RF energy deposition, and the use of a cluster electrode system. Currently, we are attempting to determine clinical efficacy of this method for intrahepatic colorectal metastases in a prospective, multi-center trial.

We have also identified and studied biophysical factors such as tissue blood flow and tissue electrical conductivity which limit the extent of RF-induced coagulation necrosis in-vivo. We have demonstrated the relationship between increased blood flow and reduced coagulation, and have shown that reduction of blood flow by mechanical or pharmacologic methods can increase coagulation volume. Additionally, we are studying and characterizing new diagnostic imaging methods for determining the extent of induced coagulation necrosis using ultrasound with microbubble contrast agents, contrast-enhanced dynamic CT, and MR imaging.

We are further attempting to couple RF delivery to other emerging technologies. For example, we have applied RF to metallic stents as a method for inducing transluminal coagulation necrosis, and are currently studying the utility of applying RF to the pancreas and other visceral organs using endoscopic ultrasonography with modified RF electrodes.

Publications

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  • Rozenblum N, Zeira E, Scaiewicz V, Bulvik B, Gourevitch S, Yotvat H, Galun E, Goldberg SN. Oncogenesis: An "Off-Target" Effect of Radiofrequency Ablation. Radiology 2015. PubMed
  • Rozenblum N, Zeira E, Bulvik B, Gourevitch S, Yotvat H, Galun E, Goldberg SN. Radiofrequency Ablation: Inflammatory Changes in the Periablative Zone Can Induce Global Organ Effects, Including Liver Regeneration. Radiology 2015. PubMed
  • Mauri G, Cova L, De Beni S, Ierace T, Tondolo T, Cerri A, Goldberg SN, Solbiati L. Real-time US-CT/MRI image fusion for guidance of thermal ablation of liver tumors undetectable with US: results in 295 cases. Cardiovasc Intervent Radiol 2015; 38:143-51. PubMed
  • Zhang E, Kircher MF, Koch M, Eliasson L, Goldberg SN, Renström E. Dynamic Magnetic Fields Remote-Control Apoptosis via Nanoparticle Rotation. ACS Nano 2014; 8:3192-201. PubMed
  • Goldberg SN. Science to practice: why debate the role of Dbait for improving tumor ablation? Radiology 2014; 270:635-7. PubMed
  • Appelbaum L, Ben-David E, Faroja M, Nissenbaum Y, Sosna J, Goldberg SN. Irreversible electroporation ablation: creation of large-volume ablation zones in in vivo porcine liver with four-electrode arrays. Radiology 2014; 270:416-24. PubMed
  • Goldberg SN. Science to practice: Can we turn the undesired heating effects of MR imaging into effective cancer therapies? Radiology 2014; 270:315-7. PubMed
  • Andriyanov AV, Koren E, Barenholz Y, Goldberg SN. Therapeutic efficacy of combining pegylated liposomal doxorubicin and radiofrequency (RF) ablation: comparison between slow-drug-releasing, non-thermosensitive and fast-drug-releasing, thermosensitive nano-liposomes. PLoS ONE 2014; 9:e92555. PubMed
  • Ben-David E, Ahmed M, Faroja M, Moussa M, Wandel A, Sosna J, Appelbaum L, Nissenbaum I, Goldberg SN. Irreversible electroporation: treatment effect is susceptible to local environment and tissue properties. Radiology 2013; 269:738-47. PubMed
  • Appelbaum L, Mahgerefteh SY, Sosna J, Goldberg SN. Image-guided fusion and navigation: applications in tumor ablation. Tech Vasc Interv Radiol 2013; 16:287-95. PubMed
  • Mauri G, Cova L, Tondolo T, Ierace T, Baroli A, Di Mauro E, Pacella CM, Goldberg SN, Solbiati L. Percutaneous Laser Ablation of Metastatic Lymph Nodes in the Neck From Papillary Thyroid Carcinoma: Preliminary Results. J Clin Endocrinol Metab 2013. PubMed
  • Moussa M, Goldberg SN, Tasawwar B, Sawant RR, Levchenko T, Kumar G, Torchilin VP, Ahmed M. Adjuvant Liposomal Doxorubicin Markedly Affects Radiofrequency Ablation-induced Effects on Periablational Microvasculature. J Vasc Interv Radiol 2013. PubMed
  • Gadaleta CD, Solbiati L, Mattioli V, Rubini G, Fazio V, Goffredo V, Vinciarelli G, Gadaleta-Caldarola G, Canniello E, Armenise F, D'Aluisio L, Gaudiano A, Ranieri G, Goldberg SN. Unresectable Lung Malignancy: Combination Therapy with Segmental Pulmonary Arterial Chemoembolization with Drug-eluting Microspheres and Radiofrequency Ablation in 17 Patients. Radiology 2013; 267:627-37. PubMed
  • Goldberg SN. Science to practice: can we expand focal interventional oncologic ablation treatments into an effective systemic therapy? Radiology 2013; 267:321-3. PubMed
  • Wang X, Zhang L, O'Neill A, Bahamon B, Alsop DC, Mier JW, Goldberg SN, Signoretti S, Atkins MB, Wood CG, Bhatt RS. Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts. Br J Cancer 2013; 108:319-26. PubMed
  • Appelbaum L, Solbiati L, Sosna J, Nissenbaum Y, Greenbaum N, Goldberg SN. Evaluation of an electromagnetic image-fusion navigation system for biopsy of small lesions: assessment of accuracy in an in vivo swine model. Acad Radiol 2013; 20:209-17. PubMed
  • Brook OR, Faintuch S, Brook A, Goldberg SN, Rofsky NM, Lenkinski RE. Embolization therapy for benign prostatic hyperplasia: Influence of embolization particle size on gland perfusion. J Magn Reson Imaging 2012. PubMed
  • Solbiati L, Ahmed M, Cova L, Ierace T, Brioschi M, Goldberg SN. Small Liver Colorectal Metastases Treated with Percutaneous Radiofrequency Ablation: Local Response Rate and Long-term Survival with Up to 10-year Follow-up. Radiology 2012; 265:958-68. PubMed
  • Ahmed M, Goldberg SN. Basic science research in thermal ablation. Surg Oncol Clin N Am 2011; 20:237-58. PubMed
  • Brook OR, Mendiratta-Lala M, Brennan D, Siewert B, Faintuch S, Goldberg SN. Imaging findings after radiofrequency ablation of adrenal tumors. AJR Am J Roentgenol 2011; 196:382-8. PubMed
  • Mendiratta-Lala M, Brennan DD, Brook OR, Faintuch S, Mowschenson PM, Sheiman RG, Goldberg SN. Efficacy of radiofrequency ablation in the treatment of small functional adrenal neoplasms. Radiology 2010; 258:308-16. PubMed
  • Yang W, Ahmed M, Elian M, Hady ES, Levchenko TS, Sawant RR, Signoretti S, Collins M, Torchilin VP, Goldberg SN. Do Liposomal Apoptotic Enhancers IncreaseTumor Coagulation and End-Point Survival in Percutaneous Radiofrequency Ablation of Tumors in a Rat Tumor Model? Radiology 2010; 257:685-96. PubMed
  • Bhatt RS, Wang X, Zhang L, Collins MP, Signoretti S, Alsop DC, Goldberg SN, Atkins MB, Mier JW. Renal cancer resistance to antiangiogenic therapy is delayed by restoration of angiostatic signaling. Mol Cancer Ther 2010; 9:2793-802. PubMed
  • Solazzo SA, Ahmed M, Schor-Bardach R, Yang W, Girnun GD, Rahmanuddin S, Levchenko T, Signoretti S, Spitz DR, Torchilin V, Goldberg SN. Liposomal Doxorubicin Increases Radiofrequency Ablation-induced Tumor Destruction by Increasing Cellular Oxidative and Nitrative Stress and Accelerating Apoptotic Pathways. Radiology 2010; 255:62-74. PubMed
  • Nour SG, Goldberg SN, Wacker FK, Rafie S, Paul S, Heidenreich JO, Rodgers M, Abdul-Karim FW, Duerk JL, Lewin JS. MR monitoring of NaCl-enhanced radiofrequency ablations: observations on low- and high-field-strength MR images with pathologic correlation. Radiology 2010; 254:449-59. PubMed
  • Appelbaum L, Sosna J, Pearson R, Perez S, Nissenbaum Y, Mertyna P, Libson E, Goldberg SN. Algorithm optimization for multitined radiofrequency ablation: comparative study in ex vivo and in vivo bovine liver. Radiology 2010; 254:430-40. PubMed
  • Mertyna P, Goldberg W, Yang W, Goldberg SN. Thermal ablation a comparison of thermal dose required for radiofrequency-, microwave-, and laser-induced coagulation in an ex vivo bovine liver model. Acad Radiol 2009; 16:1539-48. PubMed
  • Rempp H, Voigtländer M, Clasen S, Kempf S, Neugebauer A, Schraml C, Schmidt D, Claussen CD, Enderle MD, Goldberg SN, Pereira PL. Increased Ablation Zones Using a Cryo-Based Internally Cooled Bipolar RF Applicator in Ex Vivo Bovine Liver. Invest Radiol 2010; 44:763-8. PubMed
  • Callstrom MR, York JD, Gaba RC, Gemmete JJ, Gervais DA, Millward SF, Brown DB, Dupuy D, Goldberg SN, Kundu S, Rose SC, Thomas JJ, Cardella JF, . Research reporting standards for image-guided ablation of bone and soft tissue tumors. J Vasc Interv Radiol 2009; 20:1527-40. PubMed
  • Nikolic B, Faintuch S, Goldberg SN, Kuo MD, Cardella JF. Stem cell therapy: a primer for interventionalists and imagers. J Vasc Interv Radiol 2009; 20:999-1012. PubMed
  • Clark TW, Millward SF, Gervais DA, Goldberg SN, Grassi CJ, Kinney TB, Phillips DA, Sacks D, Cardella JF, . Reporting standards for percutaneous thermal ablation of renal cell carcinoma. J Vasc Interv Radiol 2009; 20:S409-16. PubMed
  • Brown DB, Gould JE, Gervais DA, Goldberg SN, Murthy R, Millward SF, Rilling WS, Geschwind JF, Salem R, Vedantham S, Cardella JF, Soulen MC, . Transcatheter therapy for hepatic malignancy: standardization of terminology and reporting criteria. J Vasc Interv Radiol 2009; 20:S425-34. PubMed
  • Goldberg SN, Grassi CJ, Cardella JF, Charboneau JW, Dodd GD, Dupuy DE, Gervais DA, Gillams AR, Kane RA, Lee FT, Livraghi T, McGahan J, Phillips DA, Rhim H, Silverman SG, Solbiati L, Vogl TJ, Wood BJ, Vedantham S, Sacks D, . Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol 2009; 20:S377-90. PubMed
  • Brown DB, Cardella JF, Sacks D, Goldberg SN, Gervais DA, Rajan DK, Vedantham S, Miller DL, Brountzos EN, Grassi CJ, Towbin RB, , Angle JF, Balter S, Clark TW, Cole PE, Drescher P, Freeman NJ, Georgia JD, Haskal Z, Hovsepian DM, Kilnani NM, Kundu S, Malloy PC, Martin LG, McGraw JK, Meranze SG, Meyers PM, Millward SF, Murphy K, Neithamer CD, Omary RA, Patel NH, Roberts AC, Schwartzberg MS, Siskin GP, Smouse HR, Swan TL, Thorpe PE, Vesely TM, Wagner LK, Wiechmann BN, Bakal CW, Lewis CA, Nemcek AA, Rholl KS. Quality improvement guidelines for transhepatic arterial chemoembolization, embolization, and chemotherapeutic infusion for hepatic malignancy. J Vasc Interv Radiol 2009; 20:S219-S226, S226.e1-10. PubMed
  • Gervais DA, Goldberg SN, Brown DB, Soulen MC, Millward SF, Rajan DK. Society of Interventional Radiology position statement on percutaneous radiofrequency ablation for the treatment of liver tumors. J Vasc Interv Radiol 2009; 20:S342-7. PubMed
  • Schor-Bardach R,Alsop DC,Pedrosa I,Solazzo SA,Wang X,Marquis RP,Atkins MB,Regan M,Signoretti S,Lenkinski RE,Goldberg SN. Does arterial spin-labeling MR imaging-measured tumor perfusion correlate with renal cell cancer response to antiangiogenic therapy in a mouse model? Radiology 2009; 251:731-42. PubMed
  • Tognolini A, Schor-Bardach R, Pianykh OS, Wilcox CJ, Raptopoulos V, Goldberg SN. Body tumor CT perfusion protocols: optimization of acquisition scan parameters in a rat tumor model. Radiology 2009; 251:712-20. PubMed
  • Nikolic B, Elian M, Mertyna P, Yam S, Goldberg SN. The effect of hepatic radiofrequency ablation on stem cell trafficking in the rat model. J Vasc Interv Radiol 2009; 20:640-7; quiz 571. PubMed
  • Gervais DA, Goldberg SN, Brown DB, Soulen MC, Millward SF, Rajan DK, . Society of Interventional Radiology position statement on percutaneous radiofrequency ablation for the treatment of liver tumors. J Vasc Interv Radiol 2008; 20:3-8. PubMed
  • Mostafa EM, Ganguli S, Faintuch S, Mertyna P, Goldberg SN. Optimal strategies for combining transcatheter arterial chemoembolization and radiofrequency ablation in rabbit VX2 hepatic tumors. J Vasc Interv Radiol 2008; 19:1740-8. PubMed
  • Solazzo S, Mertyna P, Peddi H, Ahmed M, Horkan C, Goldberg SN. RF ablation with adjuvant therapy: comparison of external beam radiation and liposomal doxorubicin on ablation efficacy in an animal tumor model. Int J Hyperthermia 2008; 24:560-7. PubMed
  • Mertyna P, Dewhirst MW, Halpern E, Goldberg W, Goldberg SN. Radiofrequency ablation: the effect of distance and baseline temperature on thermal dose required for coagulation. Int J Hyperthermia 2008; 24:550-9. PubMed
  • Ahmed M, Liu Z, Humphries S, Goldberg SN. Computer modeling of the combined effects of perfusion, electrical conductivity, and thermal conductivity on tissue heating patterns in radiofrequency tumor ablation. Int J Hyperthermia 2008; 24:577-88. PubMed
  • Goldberg SN. Can tumor growth be further inhibited by combining drugs such as bortezomib with image-guided interventional oncologic procedures? Radiology 2008; 248:323-5. PubMed
  • Sabir A,Schor-Bardach R,Wilcox CJ,Rahmanuddin S,Atkins MB,Kruskal JB,Signoretti S,Raptopoulos VD,Goldberg SN. Perfusion MDCT enables early detection of therapeutic response to antiangiogenic therapy. AJR Am J Roentgenol 2008; 191:133-9. PubMed
  • Liu Z, Ahmed M, Gervais D, Humphries S, Goldberg SN. Computer modeling of factors that affect the minimum safety distance required for radiofrequency ablation near adjacent nontarget structures. J Vasc Interv Radiol 2008; 19:1079-86. PubMed
  • Hochhaus A, Baccarani M, Deininger M, Apperley JF, Lipton JH, Goldberg SL, Corm S, Shah NP, Cervantes F, Silver RT, Niederwieser D, Stone RM, Dombret H, Larson RA, Roy L, Hughes T, Muller MC, Ezzeddine R, Countouriotis AM, Kantarjian HM. Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib. Leukemia 2008; 22:1200-6. PubMed
  • Mikhail M, Wolchok J, Goldberg SM, Dunkel IJ, Roses DF, Silverberg NB. Rapid enlargement of a malignant melanoma in a child with vitiligo vulgaris after application of topical tacrolimus. Arch Dermatol 2008; 144:560-1. PubMed
  • Gaitini D, Zivari M, Abadi S, Goldberg SN, Adam D. Evaluating tissue changes with ultrasound during radiofrequency ablation. Ultrasound Med Biol 2007; 34:586-97. PubMed
  • Ganguli S, Brennan DD, Faintuch S, Rayan ME, Goldberg SN. Immediate renal tumor involution after radiofrequency thermal ablation. J Vasc Interv Radiol 2008; 19:412-8. PubMed
  • Brennan DD, Ganguli S, Brecher CW, Goldberg SN. Thinking outside the abdominal box: safe use of the epipericardial fat pad window for percutaneous radiofrequency ablation of hepatic dome tumors. J Vasc Interv Radiol 2008; 19:133-6. PubMed
  • Brown DB, Gould JE, Gervais DA, Goldberg SN, Murthy R, Millward SF, Rilling WS, Geschwind JF, Salem R, Vedantham S, Cardella JF, Soulen MC. Transcatheter therapy for hepatic malignancy: standardization of terminology and reporting criteria. J Vasc Interv Radiol 2007; 18:1469-78. PubMed
  • Hakime A, Hines-Peralta A, Peddi H, Atkins MB, Sukhatme VP, Signoretti S, Regan M, Goldberg SN. Combination of radiofrequency ablation with antiangiogenic therapy for tumor ablation efficacy: study in mice. Radiology 2007; 244:464-70. PubMed
  • Kruskal JB, Azouz A, Korideck H, El-Hallak M, Robson SC, Thomas P, Goldberg SN. Hepatic colorectal cancer metastases: imaging initial steps of formation in mice. Radiology 2007; 243:703-11. PubMed
  • Hakime A, Peddi H, Hines-Peralta AU, Wilcox CJ, Kruskal J, Lin S, de Baere T, Raptopoulos VD, Goldberg SN. CT perfusion for determination of pharmacologically mediated blood flow changes in an animal tumor model. Radiology 2007; 243:712-9. PubMed
  • Mertyna P, Hines-Peralta A, Liu ZJ, Halpern E, Goldberg W, Goldberg SN. Radiofrequency ablation: variability in heat sensitivity in tumors and tissues. J Vasc Interv Radiol 2007; 18:647-54. PubMed
  • Solazzo SA, Ahmed M, Liu Z, Hines-Peralta AU, Goldberg SN. High-power generator for radiofrequency ablation: larger electrodes and pulsing algorithms in bovine ex vivo and porcine in vivo settings. Radiology 2007; 242:743-50. PubMed
  • Sabir A, Schor-Bardach R, Wilcox CJ, Rahmanuddin S, Atkins MB, Kruskal JB, Signoretti S, Regan M, Raptopoulos VD, Goldberg SM. Multislice CT Perfusion Imaging Enables Early Detection of Therapeutic Response to Antiangiogenic Therapy. Radiology 2007.
  • Aub. Influence of NaCl concentrations on coagulation, temperature, and electrical conductivity using a perfusion radiofrequency ablation system: an ex vivo experimental study. Cardiovasc Intervent Radiol 2006; 30:92-7. PubMed
  • Arienti V, Pretolani S, Goldberg SN, Silverman SG, Gervais DA, Lencioni R, Sacks D, Dupuy D. How to report and compare complications of image-guided ablation therapies: comments on seeding and the use of a sole common denominator for liver tumors. Radiology 2006; 241:626-627.
  • Arienti V, Pretolani S, Goldberg SN, Silverman SG, Gervais DA, Lencioni R, Sacks D, Dupuy D. How to report and compare complications of image-guided ablation therapies: comments on seeding and the use of a sole common denominator for liver tumors. Radiology 2006; 241:625-6; author reply 626-7. PubMed
  • Clark TW, Millward SF, Gervais DA, Goldberg SN, Grassi CJ, Kinney TB, Phillips DA, Sacks D, Cardella JF. Reporting standards for percutaneous thermal ablation of renal cell carcinoma. J Vasc Interv Radiol 2006; 17:1563-70. PubMed
  • Hines-Peralta A, Sukhatme V, Regan M, Signoretti S, Liu ZJ, Goldberg SN. Improved tumor destruction with arsenic trioxide and radiofrequency ablation in three animal models. Radiology 2006; 240:82-9. PubMed
  • Sosna J, Blachar A, Amitai M, Barmeir E, Peled N, Goldberg SN, Bar-Ziv J. Colonic perforation at CT colonography: assessment of risk in a multicenter large cohort. Radiology 2006; 239:457-63. PubMed
  • Hines-Peralta AU, Pirani N, Clegg P, Cronin N, Ryan TP, Liu Z, Goldberg SN. Microwave ablation: results with a 2.45-GHz applicator in ex vivo bovine and in vivo porcine liver. Radiology 2006; 239:94-102. PubMed
  • Brown DB, Cardella JF, Sacks D, Goldberg SN, Gervais DA, Rajan D, Vedantham S, Miller DL, Brountzos EN, Grassi CJ, Towbin RB. Quality improvement guidelines for transhepatic arterial chemoembolization, embolization, and chemotherapeutic infusion for hepatic malignancy. J Vasc Interv Radiol 2006; 17:225-32. PubMed
  • Hines-Peralta A, Liu ZJ, Horkan C, Solazzo S, Goldberg SN. Chemical tumor ablation with use of a novel multiple-tine infusion system in a canine sarcoma model. J Vasc Interv Radiol 2006; 17:351-8. PubMed
  • Hakime A, Peddi H, Hines- Peralta AU, Wilcox CJ, Kruskal JB, Lin S, De Baere T, Raptopoulos VD, Goldberg SN. Multislice CT perfusion enables reliable determination of pharmacologically mediated blood flow changes in an animal tumor model. Radiology 2006.
  • Goldberg SN, Bonn J, Dodd G, Dupuy D, Geschwind JH, Hicks M, Hume KM, Lee FT, Lewis CA, Lencioni RA, Omary RA, Rundback JH, Silverman S, Dorfman GS,. Society of Interventional Radiology Interventional Oncology Task Force: interventional oncology research vision statement and critical assessment of the state of research affairs. J Vasc Interv Radiol 2005; 16:1287-94. PubMed
  • Ahmed M, Lukyanov AN, Torchilin V, Tournier H, Schneider AN, Goldberg SN. Combined radiofrequency ablation and adjuvant liposomal chemotherapy: effect of chemotherapeutic agent, nanoparticle size, and circulation time. J Vasc Interv Radiol 2005; 16:1365-71. PubMed
  • Goldberg SN. Is radiofrequency ablation effective in patients with early-stage hepatocellular carcinoma and cirrhosis? Nat Clin Pract Oncol 2005; 2:438-9. PubMed
  • Goldberg SN, Grassi CJ, Cardella JF, Charboneau JW, Dodd GD, Dupuy DE, Gervais D, Gillams AR, Kane RA, Lee FT, Livraghi T, McGahan J, Phillips DA, Rhim H, Silverman SG,. Image-guided tumor ablation: standardization of terminology and reporting criteria. J Vasc Interv Radiol 2005; 16:765-78. PubMed
  • Goldberg SN, Grassi CJ, Cardella JF, Charboneau JW, Dodd GD, Dupuy DE, Gervais D, Gillams AR, Kane RA, Lee FT, Livraghi T, McGahan J, Phillips DA, Rhim H, Silverman SG, ,. Image-guided tumor ablation: standardization of terminology and reporting criteria. Radiology 2005; 235:728-39. PubMed
  • Ahmed M, Liu Z, Lukyanov AN, Signoretti S, Horkan C, Monsky WL, Torchilin VP, Goldberg SN. Combination radiofrequency ablation with intratumoral liposomal doxorubicin: effect on drug accumulation and coagulation in multiple tissues and tumor types in animals. Radiology 2005; 235:469-77. PubMed
  • Horkan C, Dalal K, Coderre JA, Kiger JL, Dupuy DE, Signoretti S, Halpern EF, Goldberg SN. Reduced tumor growth with combined radiofrequency ablation and radiation therapy in a rat breast tumor model. Radiology 2005; 235:81-8. PubMed
  • Willett CG, Del Castillo CF, Shih HA, Goldberg S, Biggs P, Clark JW, Lauwers G, Ryan DP, Zhu AX, Warshaw AL. Long-term results of intraoperative electron beam irradiation (IOERT) for patients with unresectable pancreatic cancer. Ann Surg 2005; 241:295-9. PubMed
  • Goldberg SN. Science to practice: can we differentiate residual untreated tumor from tissue responses to heat following thermal tumor ablation? Radiology 2005; 234:317-8. PubMed
  • Hines-Peralta A, Goldberg SN. Review of radiofrequency ablation for renal cell carcinoma. Clin Cancer Res 2004; 10:6328S-34S. PubMed
  • Atkins MB, Avigan DE, Bukowski RM, Childs RW, Dutcher JP, Eisen TG, Figlin RA, Finke JH, Flanigan RC, George DJ, Goldberg SN, Gordon MS, Iliopoulos O, Kaelin WG, Linehan WM, Lipton A, Motzer RJ, Novick AC, Stadler WM, Teh BT, Yang JC, King L. Innovations and challenges in renal cancer: consensus statement from the first international conference. Clin Cancer Res 2004; 10:6277S-81S. PubMed
  • Ahmed M, Monsky WE, Girnun G, Lukyanov A, D'Ippolito G, Kruskal JB, Stuart KE, Torchilin VP, Goldberg SN. Radiofrequency thermal ablation sharply increases intratumoral liposomal doxorubicin accumulation and tumor coagulation. Cancer Res 2003; 63:6327-33. PubMed
  • Goldberg SN, Charboneau JW, Dodd GD, Dupuy DE, Gervais DA, Gillams AR, Kane RA, Lee FT, Livraghi T, McGahan JP, Rhim H, Silverman SG, Solbiati L, Vogl TJ, Wood BJ,. Image-guided tumor ablation: proposal for standardization of terms and reporting criteria. Radiology 2003; 228:335-45. PubMed
  • D'Ippolito G, Ahmed M, Girnun GD, Stuart KE, Kruskal JB, Halpern EF, Goldberg SN. Percutaneous tumor ablation: reduced tumor growth with combined radio-frequency ablation and liposomal doxorubicin in a rat breast tumor model. Radiology 2003; 228:112-8. PubMed
  • Livraghi T, Solbiati L, Meloni MF, Gazelle GS, Halpern EF, Goldberg SN. Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. Radiology 2003; 226:441-51. PubMed
  • Monsky WL, Kruskal JB, Lukyanov AN, Girnun GD, Ahmed M, Gazelle GS, Huertas JC, Stuart KE, Torchilin VP, Goldberg SN. Radio-frequency ablation increases intratumoral liposomal doxorubicin accumulation in a rat breast tumor model. Radiology 2002; 224:823-9. PubMed
  • D'Ippolito G, Goldberg SN. Radiofrequency ablation of hepatic tumors. Tech Vasc Interv Radiol 2003; 5:141-55. PubMed
  • Goldberg SN, Ahmed M, Weinstein J, Hare B, Bloch S, Sheiman RG. Low-power transverse ultrasonic treatment of portal vein thrombosis in an animal model. J Vasc Interv Radiol 2002; 13:915-21. PubMed
  • Kruskal JB, Goldberg SN. Emerging therapies for hepatocellular carcinoma: opportunities for radiologists. J Vasc Interv Radiol 2002; 13:S253-8. PubMed
  • Goldberg SN, Kamel IR, Kruskal JB, Reynolds K, Monsky WL, Stuart KE, Ahmed M, Raptopoulos V. Radiofrequency ablation of hepatic tumors: increased tumor destruction with adjuvant liposomal doxorubicin therapy. AJR Am J Roentgenol 2002; 179:93-101. PubMed
  • Goldberg SN, Girnan GD, Lukyanov AN, Ahmed M, Monsky WL, Gazelle GS, Huertas JC, Stuart KE, Jacobs T, Torchillin VP, Halpern EF, Kruskal JB. Percutaneous tumor ablation: increased necrosis with combined radio-frequency ablation and intravenous liposomal doxorubicin in a rat breast tumor model. Radiology 2002; 222:797-804. PubMed
  • Dupuy DE, Goldberg SN. Image-guided radiofrequency tumor ablation: challenges and opportunities--part II. J Vasc Interv Radiol 2001; 12:1135-48. PubMed
  • Kamel IR, Kruskal JB, Keogan MT, Goldberg SN, Warmbrand G, Raptopoulos V. Multidetector CT of potential right-lobe liver donors. AJR Am J Roentgenol 2001; 177:645-51. PubMed
  • Shetty SK, Rosen MP, Raptopoulos V, Goldberg SN. Cost-effectiveness of percutaneous radiofrequency ablation for malignant hepatic neoplasms. J Vasc Interv Radiol 2001; 12:823-33. PubMed
  • Garpestad E, Goldberg S, Herth F, Garland R, LoCicero J, Thurer R, Ernst A. CT fluoroscopy guidance for transbronchial needle aspiration: an experience in 35 patients. Chest 2001; 119:329-32. PubMed
  • Kamel IR, Kruskal JB, Warmbrand G, Goldberg SN, Pomfret EA, Raptopoulos V. Accuracy of volumetric measurements after virtual right hepatectomy in potential donors undergoing living adult liver transplantation. AJR Am J Roentgenol 2001; 176:483-7. PubMed
  • Gazelle GS, Goldberg SN, Solbiati L, Livraghi T. Tumor ablation with radio-frequency energy. Radiology 2000; 217:633-46. PubMed
  • Dupuy DE, Hong R, Oliver B, Goldberg SN. Radiofrequency ablation of spinal tumors: temperature distribution in the spinal canal. AJR Am J Roentgenol 2000; 175:1263-6. PubMed
  • Goldberg SN, Gazelle GS, Compton CC, Mueller PR, Tanabe KK. Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation. Cancer 2000; 88:2452-63. PubMed
  • Gervais D, Wood B, McGovern FJ, Goldberg SN, Mueller PR.. Radio-frequency Ablation of Renal Cell Carcinoma: Early Clinical Experience. Radiology 2000; 217:665-672.
  • Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, Ierace T, Solbiati L, Gazelle GS. Hepatocellular carcinoma: radio-frequency ablation of medium and large lesions. Radiology 2000; 214:761-8. PubMed
  • Goldberg SN, Gazelle GS, Mueller PR. Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Roentgenol 2000; 174:323-31. PubMed
  • Azabdaftari G, Goldberg SN, Wang HH. Efficacy of on-site specimen adequacy evaluation of image-guided fine and core needle biopsies. Acta Cytol 2010; 54:132-7. PubMed
  • Mendiratta-Lala M, Brook OR, Midkiff BD, Brennan DD, Thornton E, Faintuch S, Sheiman RG, Goldberg SN. Quality Initiatives: Strategies for Anticipating and Reducing Complications and Treatment Failures in Hepatic Radiofrequency Ablation. Radiographics 2010; 30:1107-22. PubMed
  • Bhatt R, Wang X, Zhang L, Bhasin M, Libermann T, O’Neil A, Signoretti S, Atkins M, Mier J, Goldberg SN. Cox-2 inhibition delays resistance to sunitinib in RCC xenograft models. 2009.
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