Photo of S. Ted Treves,  MD

S. Ted Treves, MD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-7935
Fax: (617) 730-0620


treves@childrens.harvard.edu

S. Ted Treves, MD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Staff Physician, Nuclear Medicine and Molecular Imaging, Boston Children's Hospital
  • Director, Joint Program in Nuclear Medicine, Harvard Medical School

Research Abstract

Systems integration in medical imaging; optimization of nuclear medicine in pediatrics.

Publications

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  • Lassmann M, Treves ST. Pediatric Radiopharmaceutical Administration: Harmonization of the 2007 EANM Paediatric Dosage Card (Version 1.5.2008) and the 2010 North American Consensus guideline. Eur J Nucl Med Mol Imaging 2014. PubMed
  • Lassmann M, Treves ST, . Paediatric radiopharmaceutical administration: harmonization of the 2007 EANM paediatric dosage card (version 1.5.2008) and the 2010 North American consensus guidelines. Eur J Nucl Med Mol Imaging 2014; 41:1036-41. PubMed
  • Treves ST, Falone AE, Fahey FH. Pediatric Nuclear Medicine and Radiation Dose. Semin Nucl Med 2014; 44:202-209. PubMed
  • Treves ST, Lassmann M, . International Guidelines for Pediatric Radiopharmaceutical Administered Activities. J Nucl Med 2014. PubMed
  • Markelewicz RJ, Lorenzen WA, Shusterman S, Grant FD, Fahey FH, Treves ST. Radiation exposure to family caregivers and nurses of pediatric neuroblastoma patients receiving 131I-metaiodobenzylguanidine (131I-MIBG) therapy. Clin Nucl Med 2013; 38:604-7. PubMed
  • Dearling JL, Barnes JW, Panigrahy D, Zimmerman RE, Fahey F, Treves ST, Morrison MS, Kieran MW, Packard AB. Specific uptake of 99mTc-NC100692, an 留v硫3-targeted imaging probe, in subcutaneous and orthotopic tumors. Nucl Med Biol 2013; 40:788-94. PubMed
  • Horky LL, Treves ST. PET and SPECT in Brain Tumors and Epilepsy. Neurosurg Clin N Am 2011; 22:169-84. PubMed
  • Gelfand MJ, Parisi MT, Treves ST, . Pediatric radiopharmaceutical administered doses: 2010 North American consensus guidelines. J Nucl Med 2011; 52:318-22. PubMed
  • Zukotynski KA, Fahey FH, Kocak M, Alavi A, Wong TZ, Treves ST, Shulkin BL, Haas-Kogan DA, Geyer JR, Vajapeyam S, Boyett JM, Kun LE, Poussaint TY. Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. J Nucl Med 2011; 52:188-95. PubMed
  • Dearling JL, Voss SD, Dunning P, Snay E, Fahey F, Smith SV, Huston JS, Meares CF, Treves ST, Packard AB. Imaging cancer using PET--the effect of the bifunctional chelator on the biodistribution of a (64)Cu-labeled antibody. Nucl Med Biol 2011; 38:29-38. PubMed
  • Routh JC, Grant FD, Kokorowski P, Lee RS, Fahey FH, Treves ST, Nelson CP. Costs and Consequences of Universal Sibling Screening for Vesicoureteral Reflux: Decision Analysis. Pediatrics 2010; 126:865-71. PubMed
  • Gelfand MJ, Sharp SE, Treves ST, Fahey FH, Parisi MT, Alessio AM. Estimated cumulative radiation dose from PET/CT in children with malignancies. Pediatr Radiol 2010; 40:1712-3; author reply 1714-5. PubMed
  • Vukcevic M, Broman M, Islander G, Bodelsson M, Ranklev-Twetman E, Müller CR, Treves S. Functional properties of RYR1 mutations identified in Swedish patients with malignant hyperthermia and central core disease. Anesth Analg 2010; 111:185-90. PubMed
  • Williams G, Fahey FH, Treves ST, Kocak M, Pollack IF, Boyett JM, Kun LE, Poussaint TY. Exploratory evaluation of two-dimensional and three-dimensional methods of FDG PET quantification in pediatric anaplastic astrocytoma: a report from the Pediatric Brain Tumor Consortium (PBTC). Eur J Nucl Med Mol Imaging 2008; 35:1651-8. PubMed
  • Treves S, Jungbluth H, Muntoni F, Zorzato F. Congenital muscle disorders with cores: the ryanodine receptor calcium channel paradigm. Curr Opin Pharmacol 2008; 8:319-26. PubMed
  • Bleunven C, Treves S, Jinyu X, Leo E, Ronjat M, De Waard M, Kern G, Flucher BE, Zorzato F. SRP-27 is a novel component of the supramolecular signalling complex involved in skeletal muscle excitation-contraction coupling. Biochem J 2007; 411:343-9. PubMed
  • Grant FD, Fahey FH, Packard AB, Davis RT, Alavi A, Treves ST. Skeletal PET with 18F-fluoride: applying new technology to an old tracer. J Nucl Med 2007; 49:68-78. PubMed
  • Delbono O, Xia J, Treves S, Wang ZM, Jimenez-Moreno R, Payne AM, Messi ML, Briguet A, Schaerer F, Nishi M, Takeshima H, Zorzato F. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45. Proc Natl Acad Sci U S A 2007; 104:20108-13. PubMed
  • Ma JJ, Kang BK, Treves ST. Pediatric musculoskeletal nuclear medicine. Semin Musculoskelet Radiol 2008; 11:322-34. PubMed
  • Voss SD, Smith SV, DiBartolo N, McIntosh LJ, Cyr EM, Bonab AA, Dearling JL, Carter EA, Fischman AJ, Treves ST, Gillies SD, Sargeson AM, Huston JS, Packard AB. Positron emission tomography (PET) imaging of neuroblastoma and melanoma with 64Cu-SarAr immunoconjugates. Proc Natl Acad Sci U S A 2007; 104:17489-93. PubMed
  • Feriotto G, Finotti A, Breveglieri G, Treves S, Zorzato F, Gambari R. Transcriptional activity and Sp 1/3 transcription factor binding to the P1 promoter sequences of the human AbetaH-J-J locus. FEBS J 2007; 274:4476-90. PubMed
  • Christen V, Treves S, Duong FH, Heim MH. Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A. Hepatology 2007; 46:558-65. PubMed
  • Bracci L, Vukcevic M, Spagnoli G, Ducreux S, Zorzato F, Treves S. Ca2+ signaling through ryanodine receptor 1 enhances maturation and activation of human dendritic cells. J Cell Sci 2007; 120:2232-40. PubMed
  • Adams MJ, Lipsitz SR, Colan SD, Tarbell NJ, Treves ST, Diller L, Greenbaum N, Mauch P, Lipshultz SE. Cardiovascular Status in Long-Term Survivors of Hodgkin's Disease Treated With Chest Radiotherapy. J Clin Oncol 2004; 22:3139-48. PubMed
  • Treves ST, Packard AB, Fung LC. Assessment of rapid changes in renal blood flow with (191m)ir, an ultra-short-lived radionuclide. J Nucl Med 2004; 45:508-11. PubMed
  • Drubach LA, Connolly SA, Treves ST, Connolly LP. Stress-induced fracture involving a nonossifying fibroma. Clin Nucl Med 2003; 29:41-2. PubMed
  • Gerbaudo VH, Britz-Cunningham S, Sugarbaker DJ, Treves ST. Metabolic significance of the pattern, intensity and kinetics of 18F-FDG uptake in malignant pleural mesothelioma. Thorax 2003; 58:1077-82. PubMed
  • Rajadhyaksha C, Connolly LP, Connolly SA, Treves ST. Aneurysmal bone cyst of the sacrum: value of three-phase imaging. Clin Nucl Med 2003; 28:933-5. PubMed
  • Stauss J, Connolly LP, Connolly SA, Zurakowski D, Treves ST, Peters CA. Dynamic renal scintigraphy in children with vesicoureteral reflux and suspected coexisting ureteropelvic junction obstruction. J Urol 2003; 170:1966-70. PubMed
  • Anderson AA, Treves S, Biral D, Betto R, Sandon. The novel skeletal muscle sarcoplasmic reticulum JP-45 protein. Molecular cloning, tissue distribution, developmental expression, and interaction with alpha 1.1 subunit of the voltage-gated calcium channel. J Biol Chem 2003; 278:39987-92. PubMed
  • Stauss J, Connolly LP, Perez-Rossello J, Treves ST. Pediatric acute pyelonephritis: diagnosis facilitated by skeletal scintigraphy. Clin Nucl Med 2003; 28:855-7. PubMed
  • Stauss J, Connolly LP, Drubach LA, Treves ST. Pelvic hypoplasia after radiation therapy. Clin Nucl Med 2003; 28:847-8. PubMed
  • Connolly LP, Drubach LA, Treves ST. Localization of Tc-99m MDP in the rectus abdominis muscle without associated symptoms. Clin Nucl Med 2003; 28:769-70. PubMed
  • Hadigan C, Fishman SJ, Connolly LP, Treves ST, Nurko S. Stimulation with fatty meal (Lipomul) to assess gallbladder emptying in children with chronic acalculous cholecystitis. J Pediatr Gastroenterol Nutr 2003; 37:178-82. PubMed
  • Stauss J, Treves ST, Connolly LP. Lymphatic Tc-99m DMSA localization after partial-dose extravasation. Clin Nucl Med 2003; 28:618-9. PubMed
  • Alavi A, Blahd WH, DeNardo SJ, Graham MM, Holder LE, Larson SM, Maurer AH, Miller TR, Nusynowitz ML, Palestro CJ, Parker JA, Schelbert HR, Taylor AT, Treves ST. Components of professional competence for nuclear medicine physicians. J Nucl Med 2003; 44:988-90. PubMed
  • Connolly LP, d'Hemecourt PA, Connolly SA, Drubach LA, Micheli LJ, Treves ST. Skeletal scintigraphy of young patients with low-back pain and a lumbosacral transitional vertebra. J Nucl Med 2003; 44:909-14. PubMed
  • Stauss J, Connolly LP, Perez-Rossello J, Treves ST. Skeletal scintigraphy of possible os calcaneus secundarius. Clin Nucl Med 2003; 28:424-5. PubMed
  • Zorzato F, Yamaguchi N, Xu L, Meissner G, M. Clinical and functional effects of a deletion in a COOH-terminal lumenal loop of the skeletal muscle ryanodine receptor. Hum Mol Genet 2003; 12:379-88. PubMed
  • Skeie GO, Mygland A, Treves S, Gilhus NE, Aarli JA, Zorzato F. Ryanodine receptor antibodies in myasthenia gravis: epitope mapping and effect on calcium release in vitro. Muscle Nerve 2003; 27:81-9. PubMed
  • Connolly LP, Connolly SA, Drubach LA, Jaramillo D, Treves ST. Acute hematogenous osteomyelitis of children: assessment of skeletal scintigraphy-based diagnosis in the era of MRI. J Nucl Med 2002; 43:1310-6. PubMed
  • Girard T, Treves S, Censier K, Mueller CR, Zorzato F, Urwyler A. Phenotyping malignant hyperthermia susceptibility by measuring halothane-induced changes in myoplasmic calcium concentration in cultured human skeletal muscle cells. Br J Anaesth 2002; 89:571-9. PubMed
  • Gerbaudo VH, Sugarbaker DJ, Britz-Cunningham S, Di Carli MF, Mauceri C, Treves ST. Assessment of malignant pleural mesothelioma with (18)F-FDG dual-head gamma-camera coincidence imaging: comparison with histopathology. J Nucl Med 2002; 43:1144-9. PubMed
  • Packard AB, Kronauge JF, Barbarics E, Kiani S, Treves ST. Synthesis and biodistribution of a Lipophilic 64Cu-labeled monocationic Copper(II) complex. Nucl Med Biol 2002; 29:289-94. PubMed
  • Treves S, Pouliquin R, Moccagatta L, Zorzato F. Functional properties of EGFP-tagged skeletal muscle calcium-release channel (ryanodine receptor) expressed in COS-7 cells: sensitivity to caffeine and 4-chloro-m-cresol. Cell Calcium 2002; 31:1-12. PubMed
  • Girard T, Cavagna D, Padovan E, Spagnoli G, Urwyler A, Zorzato F, Treves S. B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators. J Biol Chem 2001; 276:48077-82. PubMed
  • Connolly LP, Connolly SA, Treves ST. Allograft tibial plateau fracture. Clin Nucl Med 2001; 26:1035-6. PubMed
  • Connolly LP, Zurakowski D, Connolly SA, Peters CA, Drubach LA, Cilento BG, Treves ST. Natural history of vesicoureteral reflux in girls after age 5 years. J Urol 2001; 166:2359-63. PubMed
  • Tilgen N, Zorzato F, Halliger-Keller B, Muntoni F, Sewry C, Palmucci LM, Schneider C, Hauser E, Lehmann-Horn F, M. Identification of four novel mutations in the C-terminal membrane spanning domain of the ryanodine receptor 1: association with central core disease and alteration of calcium homeostasis. Hum Mol Genet 2001; 10:2879-87. PubMed
  • Connolly LP, Connolly SA, Treves ST. Ectopic ureterocele with pyonephrosis: a potential mimic of acute pyelonephritis on renal cortical scintigraphy. Clin Nucl Med 2001; 26:938-9. PubMed
  • Girard T, Urwyler A, Censier K, Mueller CR, Zorzato F, Treves S. Genotype-phenotype comparison of the Swiss malignant hyperthermia population. Hum Mutat 2001; 18:357-8. PubMed
  • Connolly LP, Connolly SA, Drubach LA, Treves ST. Pyonephrosis in a duplex kidney: diagnosis facilitated by skeletal scintigraphy. Clin Nucl Med 2001; 26:629-30. PubMed
  • Connolly LP, Connolly SA, Treves ST. Renal malposition secondary to omphalocele shown on hepatobiliary scintigraphy. Clin Nucl Med 2001; 26:546-8. PubMed
  • Drubach LA, Connolly LP, D'Hemecourt PA, Treves ST. Assessment of the clinical significance of asymptomatic lower extremity uptake abnormality in young athletes. J Nucl Med 2001; 42:209-12. PubMed
  • Connolly LP, Connolly SA, Treves ST. Differentiation of anterior tibial stress fracture from osteoid osteoma. Clin Nucl Med 2001; 26:54-6. PubMed
  • Treves S, Feriotto G, Moccagatta L, Gambari R, Zorzato F. Molecular cloning, expression, functional characterization, chromosomal localization, and gene structure of junctate, a novel integral calcium binding protein of sarco(endo)plasmic reticulum membrane. J Biol Chem 2000; 275:39555-68. PubMed
  • Rende M, Brizi E, Conner J, Treves S, Censier K, Provenzano C, Taglialatela G, Sanna PP, Donato R. Nerve growth factor (NGF) influences differentiation and proliferation of myogenic cells in vitro via TrKA. Int J Dev Neurosci 2001; 18:869-85. PubMed
  • Paltiel HJ, Mulkern RV, Perez-Atayde A, Connolly LP, Zurakowski D, Treves ST, Atala A. Effect of chronic, low-pressure, sterile vesicoureteral reflux on renal growth and function in a porcine model: a radiologic and pathologic study. Radiology 2000; 217:507-15. PubMed
  • Nguyen HT, Bauer SB, Peters CA, Connolly LP, Gobet R, Borer JG, Barnewolt CE, Ephraim PL, Treves ST, Retik AB. 99m Technetium dimercapto-succinic acid renal scintigraphy abnormalities in infants with sterile high grade vesicoureteral reflux. J Urol 2000; 164:1674-8; discussion 1678-9. PubMed
  • Zorzato F, Anderson AA, Ohlendieck K, Froemming G, Guerrini R, Treves S. Identification of a novel 45 kDa protein (JP-45) from rabbit sarcoplasmic-reticulum junctional-face membrane. Biochem J 2000; 351 Pt 2:537-43. PubMed
  • Drubach LA, Connolly LP, Poussaint TY, Faul PN, Treves ST. Role of intraoperative skeletal scintigraphy in the localization of osteoblastomas. Clin Nucl Med 2000; 25:819-20. PubMed
  • Lin E, Connolly LP, Zurakowski D, DiCanzio J, Drubach L, Mitchell K, Tetrault T, Laffin SP, Treves ST. Reproducibility of renal length measurements with 99mTc-DMSA SPECT. J Nucl Med 2000; 41:1632-5. PubMed
  • Cavagna D, Zorzato F, Babini E, Prestipino G, Treves S. Methyl p-hydroxybenzoate (E-218) a preservative for drugs and food is an activator of the ryanodine receptor Ca(2+) release channel. Br J Pharmacol 2000; 131:335-41. PubMed
  • Connolly LP, Zurakowski D, Peters CA, Dicanzio J, Ephraim P, Paltiel HJ, Share JC, Treves ST. Variability of diuresis renography interpretation due to method of post-diuretic renal pelvic clearance half-time determination. J Urol 2000; 164:467-71. PubMed
  • Kaefer M, Curran M, Treves ST, Bauer S, Hendren WH, Peters CA, Atala A, Diamond D, Retik A. Sibling vesicoureteral reflux in multiple gestation births. Pediatrics 2000; 105:800-4. PubMed
  • Lin E, Connolly LP, Drubach L, Zurakowski D, DiCanzio J, Mitchell K, Treves ST. Effect of early emptying on quantitation and interpretation of liquid gastric emptying studies of infants and young children. J Nucl Med 2000; 41:596-9. PubMed
  • Benacquista BL, Sharma MR, Sams. Amino acid residues 4425-4621 localized on the three-dimensional structure of the skeletal muscle ryanodine receptor. Biophys J 2000; 78:1349-58. PubMed
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