Photo of Sandra S. McAllister,  PhD

Sandra S. McAllister, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 355-9059
Fax: (617) 355-9093


smcallister1@partners.org

Sandra S. McAllister, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Associate Scientist, Hematology Division, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Recurrence of cancer in the form of metastatic disease accounts for more than 90% of cancer deaths; however, tumor metastasis is considered an inefficient process whereby disseminated tumor cells remain undetected for protracted periods of time. Remarkably little is known about processes that serve to convert indolent tumors – such as the metastases that disseminate from a primary tumor – into overt, life-threatening tumors. Our prior work lead to the discovery that certain indolent tumor cells can respond to systemic cues to become overt, detectable tumors. These systemic cues were actually generated by aggressively growing tumors located at distant anatomical sites. Thus, we found that human breast carcinomas (termed “Instigators”) facilitate growth of otherwise-indolent tumor cells and micrometastases (termed “Responders”) located in different anatomical sites within host animals. We termed this action-at-a-distance “Systemic Instigation”. Therefore, we think of cancer as a disease that is capable of actively perturbing as well as responding to the host systemic environment. The view that tumor cells escape detection and remain indolent for protracted periods is not limited to disseminated tumor cells, but can also apply to primary tumors. Our research is focused on identifying systemic factors that contribute to tumor progression and finding ways to interdict their function. It is our hope that such information will ultimately lead to new therapies to treat cancer patients.

Publications

Powered by Harvard Catalyst
  • Alspach E, Flanagan KC, Luo X, Ruhland MK, Huang H, Pazolli E, Donlin MJ, Marsh T, Piwnica-Worms D, Monahan J, Novack DV, McAllister SS, Stewart SA. p38MAPK plays a crucial role in stromal mediated tumorigenesis. 2014. PubMed
  • Castaño Z, Marsh T, Tadipatri R, Kuznetsov HS, Al-Shahrour F, Paktinat M, Greene-Colozzi A, Nilsson B, Richardson AL, McAllister SS. Stromal EGF and igf-I together modulate plasticity of disseminated triple-negative breast tumors. 2013; 3:922-35. PubMed
  • Marsh T, Pietras K, McAllister SS. Fibroblasts as architects of cancer pathogenesis. Biochim Biophys Acta 2012. PubMed
  • Castaño Z, Fillmore CM, Kim CF, McAllister SS. The bed and the bugs: interactions between the tumor microenvironment and cancer stem cells. Semin Cancer Biol 2012; 22:462-70. PubMed
  • Kuznetsov HS, Marsh T, Markens BA, Castaño Z, Greene-Colozzi A, Hay SA, Brown VE, Richardson AL, Signoretti S, Battinelli EM, McAllister SS. Identification of Luminal Breast Cancers that Establish a Tumor Supportive Macroenvironment Defined by Pro-Angiogenic Platelets and Bone Marrow Derived Cells. 2012. PubMed
  • McAllister SS. Got a light? Illuminating lung cancer. Sci Transl Med 2012; 4:142fs22. PubMed
  • Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, Bray MA, Carpenter AE, Jirström K, Magnusson K, Ebert BL, Pontén F, Weinberg RA, McAllister SS. Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest 2011; 121:784-99. PubMed
  • Castaño Z, Tracy K, McAllister SS. The tumor macroenvironment and systemic regulation of breast cancer progression. Int J Dev Biol 2011; 55:889-97. PubMed
  • McAllister SS, Weinberg RA. Tumor-host interactions: a far-reaching relationship. J Clin Oncol 2010; 28:4022-8. PubMed
  • Godar S, Ince TA, Bell GW, Feldser D, Donaher JL, Bergh J, Liu A, Miu K, Watnick RS, Reinhardt F, McAllister SS, Jacks T, Weinberg RA. Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell 2008; 134:62-73. PubMed
  • McAllister SS, Gifford AM, Greiner AL, Kelleher SP, Saelzler MP, Ince TA, Reinhardt F, Harris LN, Hylander BL, Repasky EA, Weinberg RA. Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell 2008; 133:994-1005. PubMed
  • McAllister SS, Becker-Hapak M, Pintucci G, Pagano M, Dowdy SF. Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol 2002; 23:216-28. PubMed
  • Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum SL, Dowdy SF, Kawamura J, Hruska KA. Rho family GTPases regulate VEGF-stimulated endothelial cell motility. Exp Cell Res 2001; 269:73-87. PubMed
  • Becker-Hapak M, McAllister SS, Dowdy SF. TAT-mediated protein transduction into mammalian cells. Methods 2001; 24:247-56. PubMed
  • Chellaiah MA, Soga N, Swanson S, McAllister S, Alvarez U, Wang D, Dowdy SF, Hruska KA. Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J Biol Chem 2000; 275:11993-2002. PubMed
Hide