Photo of Shailja Pathania,  PhD

Shailja Pathania, PhD

University Of Massachusetts - Boston

University Of Massachusetts - Boston
Phone: (617) 287-6398


shailja.pathania@umb.edu

Shailja Pathania, PhD

University Of Massachusetts - Boston

EDUCATIONAL TITLES

  • Assistant Professor, Biology, University Of Massachusetts - Boston

DF/HCC PROGRAM AFFILIATION

Research Abstract

Women with mutations in hereditary cancer genes, BRCA1 and BRCA2, are highly predisposed to breast cancer (lifetime risk 50-80%), ovarian cancer (lifetime risk 15-40%), and men with mutations in BRCA2 are predisposed to pancreatic, and prostate cancer. How a normal, presumably healthy cell in these mutation carriers transforms into a tumor cell is largely unknown. The primary research interest of our laboratory is to understand 1) how and when normal, presumably healthy cells become tumor cells, and 2) how can we leverage these mechanistic insights to design better preventive and therapeutic treatment strategies. We are addressing these questions in the setting of hereditary breast and ovarian cancer by studying genes like BRCA1, BRCA2, PALB2, Rad51C and others.

Publications

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  • Wang H, Bierie B, Li AG, Pathania S, Toomire K, Dimitrov SD, Liu B, Gelman R, Giobbie-Hurder A, Feunteun J, Polyak K, Livingston DM. BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. Mol Cell 2016. PubMed
  • Hatchi E, Skourti-Stathaki K, Ventz S, Pinello L, Yen A, Kamieniarz-Gdula K, Dimitrov S, Pathania S, McKinney KM, Eaton ML, Kellis M, Hill SJ, Parmigiani G, Proudfoot NJ, Livingston DM. BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair. Mol Cell 2015; 57:636-47. PubMed
  • Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman-Colin C, Su Y, Ting DT, Polyak K, Richardson AL, Feunteun J, Garber JE, Livingston DM. BRCA1 haploinsufficiency for replication stress suppression in primary cells. Nat Commun 2014; 5:5496. PubMed
  • Dimitrov SD, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston DM. Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle. Genes Dev 2013; 27:2274-91. PubMed
  • Pathania S, Nguyen J, Hill SJ, Scully R, Adelmant GO, Marto JA, Feunteun J, Livingston DM. BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell 2011. PubMed
  • Johnson N, Cai D, Kennedy RD, Pathania S, Arora M, Li YC, D'Andrea AD, Parvin JD, Shapiro GI. Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage. Mol Cell 2009; 35:327-39. PubMed
  • Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM. Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev 2006; 20:34-46. PubMed