Our laboratory is interested in understanding the basic relationships at the cellular level that define a pathological state, and in using this knowledge to develop novel strategies or medicines for treating disease.
How does the cellular microenvironment modulate cellular functions or vice versa? Can the complex sugars that constitute the microenvironment play a cohesive role in intracellular regulation at the protein signaling or genetic levels? These are some key questions that we are probing using novel tools to dissect the complex sugars and connecting what we learn with changes we observe in genetic and protein-signaling. We are using this understanding to engineer novel therapeutic approaches for new drug discovery, for hybrid nanotechnology applications for novel therapeutic strategies, and for regenerative medicine using directed stem cell differentiation.
Basu S, Harfouche R, Soni S, Chimote G, Mashelkar RA, Sengupta S. Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7957-61. Featured on PNAS Highlights, Forbes, MSN News, CBS, The Telegraph, Yahoo News, Harvard Website.
Sengupta S, Sasisekharan R. Exploiting nanotechnology to target cancer. Br J Cancer. 2007 May 7;96(9):1315-9.
Sengupta S*, Eavarone DA*, Capila I, Zhao G, Watson N, Kiziltepe T, Sasisekharan R. Novel cancer therapy through temporal targeting of both tumor cells and neovasculature using a unique nanoscale delivery system. Nature (2005) 436, 568-572.