Photo of Stacy Wang Gray,  MD, AM

Stacy Wang Gray, MD, AM

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute


stacyw_gray@dfci.harvard.edu

Stacy Wang Gray, MD, AM

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Gray’s research focuses on understanding the social, ethical and medical outcomes related to the use of genomic technologies in cancer care. Her previous and ongoing work focuses on direct-to-consumer genetic testing, physician decision-making in areas of uncertainty, and cancer patient information seeking. Her work aims to understand the relationships between information dissemination, on an individual and population level, and the appropriate and inappropriate adoption of personalized cancer technologies. By studying the way in which information exposure relates to the uptake of genomic technologies and targeted therapies, Dr. Gray aims to understand if and how knowledge and uncertainty contribute to variations in cancer care. Dr. Gray leads a project that aims to establish a robust framework for the generation, interpretation, and clinical implementation of cancer whole-exome sequencing (WES). She and her colleagues are exploring the impact of the integration of somatic and germline WES on patients, oncologists, and institutional policies and practices. Through this work Dr. Gray examines the myriad ethical and social issues provoked by sequencing in cancer care in order to inform the design of systems that harness these emerging technologies and integrate them into high quality high impact cancer care.

Publications

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  • Gray SW, Cronin A, Bair E, Lindeman N, Viswanath V, Janeway KA. Marketing of personalized cancer care on the web: an analysis of internet websites. Journal of the National Cancer Institute 2015. PubMed
  • Kehl KL, Gray SW, Kim B, Kahn KL, Haggstrom D, Roudier M, Keating NL. Oncologists' experiences with drug shortages. J Oncol Pract 2015; 11:e154-62. PubMed
  • Jarvik GP, Amendola LM, Berg JS, Brothers K, Clayton EW, Chung W, Evans BJ, Evans JP, Fullerton SM, Gallego CJ, Garrison NA, Gray SW, Holm IA, Kullo IJ, Lehmann LS, McCarty C, Prows CA, Rehm HL, Sharp RR, Salama J, Sanderson S, Van Driest SL, Williams MS, Wolf SM, Wolf WA, , , Burke W. Return of genomic results to research participants: the floor, the ceiling, and the choices in between. Am J Hum Genet 2014; 94:818-26. PubMed
  • Van Allen EM, Wagle N, Stojanov P, Perrin DL, Cibulskis K, Marlow S, Jane-Valbuena J, Friedrich DC, Kryukov G, Carter SL, McKenna A, Sivachenko A, Rosenberg M, Kiezun A, Voet D, Lawrence M, Lichtenstein LT, Gentry JG, Huang FW, Fostel J, Farlow D, Barbie D, Gandhi L, Lander ES, Gray SW, Joffe S, Janne P, Garber J, MacConaill L, Lindeman N, Rollins B, Kantoff P, Fisher SA, Gabriel S, Getz G, Garraway LA. Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. Nat Med 2014; 20:682-8. PubMed
  • Gray SW, Hicks-Courant K, Cronin A, Rollins BJ, Weeks JC. Physicians' attitudes about multiplex tumor genomic testing. J Clin Oncol 2014; 32:1317-23. PubMed
  • Gray SW, Martins Y, Feuerman LZ, Bernhardt BA, Biesecker BB, Christensen KD, Joffe S, Rini C, Veenstra D, McGuire AL. Social and behavioral research in genomic sequencing: approaches from the Clinical Sequencing Exploratory Research Consortium Outcomes and Measures Working Group. Genet Med 2014. PubMed
  • Tan AS, Gibson L, Zafar HM, Gray SW, Hornik RC, Armstrong K. Associations between cancer-related information seeking and receiving PET imaging for routine cancer surveillance--an analysis of longitudinal survey data. Cancer Epidemiol Biomarkers Prev 2014; 23:481-9. PubMed
  • Berg JS, Amendola LM, Eng C, Van Allen E, Gray SW, Wagle N, Rehm HL, DeChene ET, Dulik MC, Hisama FM, Burke W, Spinner NB, Garraway L, Green RC, Plon S, Evans JP, Jarvik GP, . Processes and preliminary outputs for identification of actionable genes as incidental findings in genomic sequence data in the Clinical Sequencing Exploratory Research Consortium. Genet Med 2013; 15:860-7. PubMed
  • Sholl LM, Weremowicz S, Gray SW, Wong KK, Chirieac LR, Lindeman NI, Hornick JL. Combined use of ALK immunohistochemistry and FISH for optimal detection of ALK-rearranged lung adenocarcinomas. J Thorac Oncol 2013; 8:322-8. PubMed
  • Gray SW, Hicks-Courant K, Lathan CS, Garraway L, Park ER, Weeks JC. Attitudes of patients with cancer about personalized medicine and somatic genetic testing. J Oncol Pract 2013; 8:329-35, 2 p following 335. PubMed
  • Tan AS, Moldovan-Johnson M, Gray SW, Hornik RC, Armstrong K. An analysis of the association between cancer-related information seeking and adherence to breast cancer surveillance procedures. Cancer Epidemiol Biomarkers Prev 2012. PubMed
  • Zhu J, Sharma DB, Gray SW, Chen AB, Weeks JC, Schrag D. Carboplatin and paclitaxel with vs without bevacizumab in older patients with advanced non-small cell lung cancer. JAMA 2012; 307:1593-601. PubMed
  • Gray SW, Abel GA. Update on Direct-to-Consumer Marketing in Oncology. J Oncol Pract 2012; 8:124-7. PubMed
  • Lee CJ, Ramírez AS, Lewis N, Gray SW, Hornik RC. Looking Beyond the Internet: Examining Socioeconomic Inequalities in Cancer Information Seeking Among Cancer Patients. Health Commun 2012. PubMed
  • Tan AS, Moldovan-Johnson M, Parvanta S, Gray SW, Armstrong K, Hornik RC. Patient-clinician information engagement improves adherence to colorectal cancer surveillance after curative treatment: results from a longitudinal study. Oncologist 2012; 17:1155-62. PubMed
  • Gray SW, Hornik RC, Schwartz JS, Armstrong K. The Impact of Risk Information Exposure on Women's Beliefs about Direct-to-Consumer Genetic Testing for BRCA Mutations. Clin Genet 2011. PubMed
  • Lewis N, Martinez LS, Freres DR, Schwartz JS, Armstrong K, Gray SW, Fraze T, Nagler RH, Bourgoin A, Hornik RC. Seeking Cancer-Related Information From Media and Family/Friends Increases Fruit and Vegetable Consumption Among Cancer Patients. Health Commun 2011. PubMed
  • Gray SW, Landrum MB, Lamont EB, McNeil BJ, Jaklitsch MT, Keating NL. Improved outcomes associated with higher surgery rates for older patients with early stage nonsmall cell lung cancer. Cancer 2011. PubMed
  • Galarce EM, Ramanadhan S, Weeks J, Schneider EC, Gray SW, Viswanath K. Class, race, ethnicity and information needs in post-treatment cancer patients. Patient Educ Couns 2011. PubMed
  • Tan AS, Bourgoin A, Gray SW, Armstrong K, Hornik RC. How does patient-clinician information engagement influence self-reported cancer-related problems?: findings from a longitudinal analysis. Cancer 2011. PubMed
  • Lee CJ, Gray SW, Lewis N. Internet use leads cancer patients to be active health care consumers. Patient Educ Couns 2010; 81 Suppl:S63-9. PubMed
  • Nagler RH, Gray SW, Romantan A, Kelly BJ, Demichele A, Armstrong K, Schwartz JS, Hornik RC. Differences in information seeking among breast, prostate, and colorectal cancer patients: Results from a population-based survey. Patient Educ Couns 2010; 81 Suppl:S54-62. PubMed
  • Kelly B, Hornik R, Romantan A, Schwartz JS, Armstrong K, DeMichele A, Fishbein M, Gray S, Hull S, Kim A, Nagler R, Niederdeppe J, Ramírez AS, Smith-McLallen A, Wong N. Cancer information scanning and seeking in the general population. J Health Commun 2010; 15:734-53. PubMed
  • Nagler RH, Romantan A, Kelly BJ, Stevens RS, Gray SW, Hull SJ, Ramirez AS, Hornik RC. How Do Cancer Patients Navigate the Public Information Environment? Understanding Patterns and Motivations for Movement Among Information Sources. J Cancer Educ 2010; 25:360-70. PubMed
  • Rogers SO, Gray SW, Landrum MB, Klabunde CN, Kahn KL, Fletcher RH, Clauser S, Tisnado D, Doucette W, Keating NL. Variations in Surgeon Treatment Recommendations for Lobectomy in Early-Stage Non-Small-Cell Lung Cancer by Patient Age and Comorbidity. Ann Surg Oncol 2010; 17:1581-8. PubMed
  • Lewis N, Gray SW, Freres DR, Hornik RC. Examining cross-source engagement with cancer-related information and its impact on doctor-patient relations. Health Commun 2010; 24:723-34. PubMed
  • Gray SW, Armstrong K, Demichele A, Schwartz JS, Hornik RC. Colon cancer patient information seeking and the adoption of targeted therapy for on-label and off-label indications. Cancer 2009; 115:1424-34. PubMed
  • Gray SW, O'Grady C, Karp L, Smith D, Schwartz JS, Hornik RC, Armstrong K. Risk information exposure and direct-to-consumer genetic testing for BRCA mutations among women with a personal or family history of breast or ovarian cancer. Cancer Epidemiol Biomarkers Prev 2009; 18:1303-11. PubMed
  • Gray SW, Hlubocky FJ, Ratain MJ, Daugherty CK. Attitudes toward research participation and investigator conflicts of interest among advanced cancer patients participating in early phase clinical trials. J Clin Oncol 2007; 25:3488-94. PubMed
  • Gray S, Olopade OI. Direct-to-consumer marketing of genetic tests for cancer: buyer beware. J Clin Oncol 2003; 21:3191-3. PubMed
  • Moran TJ, Gray S, Mikosz CA, Conzen SD. The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res 2000; 60:867-72. PubMed
  • Gray, SW. Direct-to-consumer (DTC) genetic testing in context: what oncologists need to know about the DTC industry and its potential impact on patient care 2011; 9:419-422.
  • Heimann R, Ferguson D, Gray S, Hellman S. Assessment of intratumoral vascularization (angiogenesis) in breast cancer prognosis. Breast Cancer Res Treat 1999; 52:147-58. PubMed
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