Photo of Stanley W. Ashley,  MD

Stanley W. Ashley, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-6730
Fax: (617) 264-3688


sashley@partners.org

Stanley W. Ashley, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Frank Sawyer Professor of Surgery, Surgery, Harvard Medical School
  • CMO and Senior VP for Medical Affairs, Administration, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on adaptation of the gastrointestinal epithelium, particulary after resection. We are examining the physiological regulation of the intestinal sodium transporter SGLT1 in health and disease as a novel adjunct to current therapeutic strategies. In addition, I am involved in a variety of clinical studies involving GI tumors.

Publications

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  • Xourafas D, Tavakkoli A, Clancy TE, Ashley SW. Distal Pancreatic Resection for Neuroendocrine Tumors: Is Laparoscopic Really Better than Open? J Gastrointest Surg 2015. PubMed
  • Xourafas D, Tavakkoli A, Clancy TE, Ashley SW. Noninvasive intraductal papillary mucinous neoplasms and mucinous cystic neoplasms: Recurrence rates and┬ápostoperative imaging follow-up. Surgery 2015; 157:473-83. PubMed
  • Waseem T, Duxbury M, Ashley SW, Robinson MK. Ghrelin promotes intestinal epithelial cell proliferation through PI3K/Akt pathway and EGFR trans-activation both converging to ERK 1/2 phosphorylation. Peptides 2014; 52:113-21. PubMed
  • Kelz RR, Reinke CE, Cofer JB, Ashley SW, Hebert JC, Ko CY. APDS Panel Session IV: Intersection of Surgical Outcomes and Medical Education. J Surg Educ 2012; 69:687-92. PubMed
  • Balakrishnan A, Stearns AT, Ashley SW, Tavakkolizadeh A, Rhoads DB. Restricted Feeding Phase Shifts Clock Gene and Sodium Glucose Cotransporter 1 (SGLT1) Expression in Rats. J Nutr 2010; 140:908-14. PubMed
  • Viswanathan SR, Khalpey Z, Ashley SW. Gallbladder lymphoma. Med Oncol 2010. PubMed
  • Ahmadiyeh N, Cho NL, Kellogg KC, Lipsitz SR, Moore FD, Ashley SW, Zinner MJ, Breen EM. Career satisfaction of women in surgery: perceptions, factors, and strategies. J Am Coll Surg 2010; 210:23-8. PubMed
  • Greenberg CC, Ashley SW, Schrag D. Centralization of cancer surgery: what does it mean for surgical training? J Clin Oncol 2009; 27:4637-9. PubMed
  • Abolmaali K, Balakrishnan A, Stearns AT, Rounds J, Rhoads DB, Ashley SW, Tavakkolizadeh A. Circadian variation in intestinal dihydropyrimidine dehydrogenase (DPD) expression: a potential mechanism for benefits of 5FU chrono-chemotherapy. Surgery 2009; 146:269-73. PubMed
  • Mortele KJ,Girshman J,Szejnfeld D,Ashley SW,Erturk SM,Banks PA,Silverman SG. CT-guided percutaneous catheter drainage of acute necrotizing pancreatitis: clinical experience and observations in patients with sterile and infected necrosis. AJR Am J Roentgenol 2008; 192:110-6. PubMed
  • Irani JL,Ashley SW,Brooks DC,Osteen RT,Raut CP,Russell S,Swanson RS,Whang EE,Zinner MJ,Clancy TE. Distal pancreatectomy is not associated with increased perioperative morbidity when performed as part of a multivisceral resection. J Gastrointest Surg 2008; 12:2177-82. PubMed
  • Irani JL,Cutler CS,Whang EE,Clancy TE,Russell S,Swanson RS,Ashley SW,Zinner MJ,Raut CP. Severe acute gastrointestinal graft-vs-host disease: an emerging surgical dilemma in contemporary cancer care. Arch Surg 2008; 143:1041-5; discussion 1046. PubMed
  • Raut CP, Ashley SW. How I Do It: Surgical Management of Gastrointestinal Stromal Tumors. J Gastrointest Surg 2008; 12:1592-9. PubMed
  • Tatli S,Cizginer S,Wieczorek TJ,Ashley SW,Silverman SG. Solitary littoral cell angioma of the spleen: computed tomography and magnetic resonance imaging features. J Comput Assist Tomogr 2008; 32:772-5. PubMed
  • Balakrishnan A,Stearns AT,Rhoads DB,Ashley SW,Tavakkolizadeh A. Defining the transcriptional regulation of the intestinal sodium-glucose cotransporter using RNA-interference mediated gene silencing. Surgery 2008; 144:168-73. PubMed
  • Rocha FG, Sundback CA, Krebs NJ, Leach JK, Mooney DJ, Ashley SW, Vacanti JP, Whang EE. The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine. Biomaterials 2008; 29:2884-90. PubMed
  • Stearns AT, Balakrishnan A, Rounds JD, Rhoads DB, Ashley SW, Tavakkolizadeh A. Capsaicin-sensitive vagal afferents modulate post-transcriptional regulation of the rat Na+/glucose cotransporter SGLT1. Am J Physiol Gastrointest Liver Physiol 2008; 294:G1078-83. PubMed
  • Behrns KE, Ashley SW, Hunter JG, Carr-Locke D. Early ERCP for gallstone pancreatitis: for whom and when? J Gastrointest Surg 2007; 12:629-33. PubMed
  • Waseem T, Duxbury M, Ito H, Ashley SW, Robinson MK. Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery 2008; 143:334-42. PubMed
  • Dellinger EP, Tellado JM, Soto NE, Ashley SW, Barie PS, Dugernier T, Imrie CW, Johnson CD, Knaebel HP, Laterre PF, Maravi-Poma E, Olsina Kissler JJ, Garcia MS, Utzolino S,. Re: Early Antibiotic Treatment for Severe Acute Necrotizing Pancreatitis. Ann Surg 2008; 247:394-395. PubMed
  • Wallace CA, Petrov MS, Soybel DI, Ferzoco SJ, Ashley SW, Tavakkolizadeh A. Influence of Imaging on the Negative Appendectomy Rate in Pregnancy. J Gastrointest Surg 2007; 12:46-50. PubMed
  • Hernandez A, Petrov MS, Brooks DC, Banks PA, Ashley SW, Tavakkolizadeh A. Acute pancreatitis and pregnancy: a 10-year single center experience. J Gastrointest Surg 2007; 11:1623-7. PubMed
  • Javid SH, Ashley S, Breen E. A colorectal curriculum for general surgery residents: are we ready for needs assessment? J Surg Educ 2007; 64:324-7. PubMed
  • Greenberg JA, Irani JL, Greenberg CC, Blanco MA, Lipsitz S, Ashley SW, Breen EM, Hafler JP. The ACGME competencies in the operating room. Surgery 2007; 142:180-4. PubMed
  • Liu JJ, Glickman JN, Li X, Maurer R, Ashley SW, Brooks DC, Carr-Locke DL, Saltzman JR. Smooth muscle remodeling of the gastroesophageal junction after endoluminal gastroplication. Gastrointest Endosc 2007; 65:1023-7. PubMed
  • Raut CP, Morgan JA, Ashley SW. Current issues in gastrointestinal stromal tumors: incidence, molecular biology, and contemporary treatment of localized and advanced disease. Curr Opin Gastroenterol 2007; 23:149-58. PubMed
  • Berzin TM, Rocha FG, Whang EE, Mortele KJ, Ashley SW, Banks PA. Prevalence of primary fungal infections in necrotizing pancreatitis. Pancreatology 2007; 7:63-6. PubMed
  • Liau SS, Ashley SW, Whang EE. Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma. J Gastrointest Surg 2006; 10:1254-62; discussion 1263. PubMed
  • Raut CP, Kulke MH, Glickman JN, Swanson RS, Ashley SW. Carcinoid tumors. Curr Probl Surg 2006; 43:383-450. PubMed
  • Matros E, Bailey G, Clancy T, Zinner M, Ashley S, Whang E, Redston M. Cytokeratin 20 expression identifies a subtype of pancreatic adenocarcinoma with decreased overall survival. Cancer 2005; 106:693-702. PubMed
  • Duxbury MS, Ashley SW, Whang EE. RNA interference: A mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells. Biochem Biophys Res Commun 2005; 331:459-463. PubMed
  • Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, Whang EE. RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. Clin Cancer Res 2005; 11:3433-8. PubMed
  • Clancy TE, Benoit EP, Ashley SW. Current management of acute pancreatitis. J Gastrointest Surg 2005; 9:440-52. PubMed
  • Duxbury MS, Matros E, Clancy T, Bailey G, Doff M, Zinner MJ, Ashley SW, Maitra A, Redston M, Whang EE. CEACAM6 is a novel biomarker in pancreatic adenocarcinoma and PanIN lesions. Ann Surg 2005; 241:491-6. PubMed
  • Perez A, Duxbury M, Rocha FG, Ramsanahie AP, Farivar RS, Varnholt H, Ito H, Wong H, Rounds J, Zinner MJ, Whang EE, Ashley SW. Glucagon-like peptide 2 is an endogenous mediator of postresection intestinal adaptation. JPEN J Parenter Enteral Nutr 2005; 29:97-101. PubMed
  • Ito H, Clancy TE, Osteen RT, Swanson RS, Bueno R, Sugarbaker DJ, Ashley SW, Zinner MJ, Whang EE. Adenocarcinoma of the gastric cardia: what is the optimal surgical approach? J Am Coll Surg 2004; 199:880-6. PubMed
  • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness. Biochem Biophys Res Commun 2004; 320:1096-102. PubMed
  • Duxbury MS, Ito H, Benoit E, Zinner MJ, Ashley SW, Whang EE. Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase: A novel therapeutic strategy in pancreatic cancer. Surgery 2004; 136:261-9. PubMed
  • Duxbury MS, Ito H, Benoit E, Zinner MJ, Ashley SW, Whang EE. Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. Oncogene 2004; 23:5834-42. PubMed
  • Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, Whang EE. A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Cancer Res 2004; 64:3987-93. PubMed
  • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. siRNA directed against c-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity. J Am Coll Surg 2004; 198:953-9. PubMed
  • Duxbury MS, Ito H, Ashley SW, Whang EE. CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells. J Biol Chem 2004; 279:23176-82. PubMed
  • Ito H, Duxbury M, Benoit E, Farivar RS, Gardner-Thorpe J, Zinner MJ, Ashley SW, Whang EE. Fibronectin-induced COX-2 mediates MMP-2 expression and invasiveness of rhabdomyosarcoma. Biochem Biophys Res Commun 2004; 318:594-600. PubMed
  • Duxbury MS, Ito H, Ashley SW, Whang EE. CEACAM6 as a novel target for indirect type 1 immunotoxin-based therapy in pancreatic adenocarcinoma. Biochem Biophys Res Commun 2004; 317:837-43. PubMed
  • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells. Surgery 2004; 135:555-62. PubMed
  • Duxbury MS, Grikscheit TC, Gardner-Thorpe J, Rocha FG, Ito H, Perez A, Ashley SW, Vacanti JP, Whang EE. Lymphangiogenesis in tissue-engineered small intestine. Transplantation 2004; 77:1162-6. PubMed
  • Duxbury MS, Ito H, Ashley SW, Whang EE. c-Src-dependent cross-talk between CEACAM6 and alphavbeta3 integrin enhances pancreatic adenocarcinoma cell adhesion to extracellular matrix components. Biochem Biophys Res Commun 2004; 317:133-41. PubMed
  • Ito H, Osteen RT, Bleday R, Zinner MJ, Ashley SW, Whang EE. Appendiceal adenocarcinoma: long-term outcomes after surgical therapy. Dis Colon Rectum 2004; 47:474-80. PubMed
  • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. Clin Cancer Res 2004; 10:2307-18. PubMed
  • Saund MS, Demetri GD, Ashley SW. Gastrointestinal stromal tumors (GISTs). Curr Opin Gastroenterol 2005; 20:89-94. PubMed
  • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. Oncogene 2003; 23:1539-48. PubMed
  • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma. Oncogene 2004; 23:1448-56. PubMed
  • Ito H, Matros E, Brooks DC, Osteen RT, Zinner MJ, Swanson RS, Ashley SW, Whang EE. Treatment outcomes associated with surgery for gallbladder cancer: a 20-year experience. J Gastrointest Surg 2004; 8:183-90. PubMed
  • Duxbury MS, Ashley SW, Whang EE. Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor. Biochem Biophys Res Commun 2004; 313:992-7. PubMed
  • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells. Oncogene 2004; 23:465-73. PubMed
  • Gardner-Thorpe J, Grikscheit TC, Ito H, Perez A, Ashley SW, Vacanti JP, Whang EE. Angiogenesis in tissue-engineered small intestine. Tissue Eng 2003; 9:1255-61. PubMed
  • Farivar RS, Gardner-Thorpe J, Ito H, Arshad H, Zinner MJ, Ashley SW, Whang EE. The efficacy of tyrosine kinase inhibitors on human pancreatic cancer cell lines. J Surg Res 2003; 115:219-25. PubMed
  • Ramsanahie A, Duxbury MS, Grikscheit TC, Perez A, Rhoads DB, Gardner-Thorpe J, Ogilvie J, Ashley SW, Vacanti JP, Whang EE. Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine. Am J Physiol Gastrointest Liver Physiol 2003; 285:G1345-52. PubMed
  • Duxbury MS, Ito H, Benoit E, Zinner MJ, Ashley SW, Whang EE. RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity. Biochem Biophys Res Commun 2003; 311:786-92. PubMed
  • Ito H, Perez A, Brooks DC, Osteen RT, Zinner MJ, Moore FD, Ashley SW, Whang EE. Surgical treatment of small bowel cancer: a 20-year single institution experience. J Gastrointest Surg 2003; 7:925-30. PubMed
  • Gardner-Thorpe J, Ito H, Ashley SW, Whang EE. Ribosomal protein P2: a potential molecular target for antisense therapy of human malignancies. Anticancer Res 2004; 23:4549-60. PubMed
  • Whang EE, Perez A, Ito H, Mello MM, Ashley SW, Zinner MJ. Work hours reform: perceptions and desires of contemporary surgical residents. J Am Coll Surg 2003; 197:624-30. PubMed
  • Duxbury MS, Waseem T, Ito H, Robinson MK, Zinner MJ, Ashley SW, Whang EE. Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness. Biochem Biophys Res Commun 2003; 309:464-8. PubMed
  • Ferzoco SJ, Matros E, Ashley SW. Electrical stimulation for gastroparesis: wired for success or just wired? JPEN J Parenter Enteral Nutr 2003; 27:386-7. PubMed
  • Ito H, Gardner-Thorpe J, Zinner MJ, Ashley SW, Whang EE. Inhibition of tyrosine kinase Src suppresses pancreatic cancer invasiveness. Surgery 2003; 134:221-6. PubMed
  • Gardner-Thorpe J, Ito H, Ashley SW, Whang EE. Autoantibody-mediated inhibition of pancreatic cancer cell growth in an athymic (nude) mouse model. Pancreas 2003; 27:180-9. PubMed
  • Perez A, Saltzman JR, Carr-Locke DL, Brooks DC, Osteen RT, Zinner MJ, Ashley SW, Whang EE. Benign nonampullary duodenal neoplasms. J Gastrointest Surg 2003; 7:536-41. PubMed
  • Perez A, Zinner MJ, Ashley SW, Brooks DC, Whang EE. What is the value of telerobotic technology in gastrointestinal surgery? Surg Endosc 2003; 17:811-3. PubMed
  • Whang EE, Mello MM, Ashley SW, Zinner MJ. Implementing resident work hour limitations: lessons from the New York State experience. Ann Surg 2003; 237:449-55. PubMed
  • Tavakkolizadeh A, Berger UV, Stephen AE, Kim BS, Mooney D, Hediger MA, Ashley SW, Vacanti JP, Whang EE. Tissue-engineered neomucosa: morphology, enterocyte dynamics, and SGLT1 expression topography. Transplantation 2003; 75:181-5. PubMed
  • Secor SM, Lane JS, Whang EE, Ashley SW, Diamond J. Luminal nutrient signals for intestinal adaptation in pythons. Am J Physiol Gastrointest Liver Physiol 2002; 283:G1298-309. PubMed
  • Ashley SW, Lauwers GY. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 37-2002. A 69-year-old man with painful cutaneous nodules, elevated lipase levels, and abnormal results on abdominal scanning. N Engl J Med 2002; 347:1783-91. PubMed
  • Perez A, Whang EE, Brooks DC, Moore FD, Hughes MD, Sica GT, Zinner MJ, Ashley SW, Banks PA. Is severity of necrotizing pancreatitis increased in extended necrosis and infected necrosis? Pancreas 2002; 25:229-33. PubMed
  • Perez A, Grikscheit TC, Blumberg RS, Ashley SW, Vacanti JP, Whang EE. Tissue-engineered small intestine: ontogeny of the immune system. Transplantation 2002; 74:619-23. PubMed
  • Ramsanahie AP, Perez A, Duensing AU, Zinner MJ, Ashley SW, Whang EE. Glucagon-like peptide 2 enhances intestinal epithelial restitution. J Surg Res 2002; 107:44-9. PubMed
  • Rogers SO, Lee MC, Ashley SW. Giant colonic lipoma as lead point for intermittent colo-colonic intussusception. Surgery 2002; 131:687-8. PubMed
  • Jasleen J, Ashley SW, Shimoda N, Zinner MJ, Whang EE. Glucagon-like peptide 2 stimulates intestinal epithelial proliferation in vitro. Dig Dis Sci 2002; 47:1135-40. PubMed
  • Gardner-Thorpe J, Ito H, Ashley SW, Whang EE. Differential display of expressed genes in pancreatic cancer cells. Biochem Biophys Res Commun 2002; 293:391-5. PubMed
  • Clancy TE, Ashley SW. Current management of necrotizing pancreatitis. Adv Surg 2002; 36:103-21. PubMed
  • Ashley SW, Perez A, Pierce EA, Brooks DC, Moore FD, Whang EE, Banks PA, Zinner MJ. Necrotizing pancreatitis: contemporary analysis of 99 consecutive cases. Ann Surg 2001; 234:572-9; discussion 579-80. PubMed
  • Rongione AJ, Kusske AM, Newton TR, Ashley SW, Zinner MJ, Mcfadden DW. EGF and TGF stimulate proabsorption of glucose and electrolytes by Na+/glucose cotransporter in awake canine model. Dig Dis Sci 2001; 46:1740-7. PubMed
  • Lane JS, Todd KE, Gloor B, Chandler CF, Kau AW, Ashley SW, Reber HA, McFadden DW. Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis. J Surg Res 2001; 99:365-70. PubMed
  • Tavakkolizadeh A, Berger UV, Shen KR, Levitsky LL, Zinner MJ, Hediger MA, Ashley SW, Whang EE, Rhoads DB. Diurnal rhythmicity in intestinal SGLT-1 function, V(max), and mRNA expression topography. Am J Physiol Gastrointest Liver Physiol 2001; 280:G209-15. PubMed
  • Tavakkolizadeh A, Shen R, Jasleen J, Soybel DI, Jacobs DO, Zinner MJ, Ashley SW, Whang EE. Effect of growth hormone on intestinal Na+/glucose cotransporter activity. JPEN J Parenter Enteral Nutr 2001; 25:18-22. PubMed
  • Shimoda N, Jasleen J, Rounds JD, Ashley SW, Jacobs DO. Sepsis increases the plasma membrane content of alpha1 and alpha2 isoforms of Na+-K+ adenosine triphosphatase in rat skeletal muscle. Arch Surg 2001; 136:95-100. PubMed
  • Kyriakides C, Jasleen J, Wang Y, Moore FD, Ashley SW, Hechtman HB. Neutrophils, not complement, mediate the mortality of experimental hemorrhagic pancreatitis. Pancreas 2001; 22:40-6. PubMed
  • Secor SM, Whang EE, Lane JS, Ashley SW, Diamond J. Luminal and systemic signals trigger intestinal adaptation in the juvenile python. Am J Physiol Gastrointest Liver Physiol 2000; 279:G1177-87. PubMed
  • Tavakkolizadeh A, Shen R, Abraham P, Kormi N, Seifert P, Edelman ER, Jacobs DO, Zinner MJ, Ashley SW, Whang EE. Glucagonlike peptide 2 (glp-2) promotes intestinal recovery following chemotherapy-induced enteritis. Curr Surg 2000; 57:502. PubMed
  • Chandler CF, Lane JS, Ferguson P, Thompson JE, Ashley SW. Prospective evaluation of early versus delayed laparoscopic cholecystectomy for treatment of acute cholecystitis. Am Surg 2000; 66:896-900. PubMed
  • Whang EE, Danial T, Dunn JC, Ashley SW, Reber HA, Lewin TJ, Tompkins RK. The spectrum of mucin-producing adenocarcinoma of the pancreas. Pancreas 2000; 21:147-51. PubMed
  • Tavakkolizadeh A, Shen R, Abraham P, Kormi N, Seifert P, Edelman ER, Jacobs DO, Zinner MJ, Ashley SW, Whang EE. Glucagon-like peptide 2: a new treatment for chemotherapy-induced enteritis. J Surg Res 2000; 91:77-82. PubMed
  • Linden PA, Ashley SW. Mucinous cystadenocarcinoma of the mesentery. Surgery 2000; 127:707-8. PubMed
  • Jasleen J, Shimoda N, Shen ER, Tavakkolizadeh A, Whang EE, Jacobs DO, Zinner MJ, Ashley SW. Signaling mechanisms of glucagon-like peptide 2-induced intestinal epithelial cell proliferation. J Surg Res 2000; 90:13-8. PubMed
  • Breen EM, Ashley SW. Laparoscopic surgery for Crohn's disease?--a conditional yes. Inflamm Bowel Dis 2000; 6:43-5; discussion 46-7. PubMed
  • Lewis MP, Lo SK, Reber PU, Patel A, Gloor B, Todd KE, Toyama MT, Sherman S, Ashley SW, Reber HA. Endoscopic measurement of pancreatic tissue perfusion in patients with chronic pancreatitis and control patients. Gastrointest Endosc 2000; 51:195-9. PubMed
  • Hines OJ, Whang EE, Bilchik AJ, Zinner MJ, Welton ML, Lane J, McFadden DW, Ashley SW. Role of Na+-glucose cotransport in jejunal meal-induced absorption. Dig Dis Sci 2000; 45:1-6. PubMed
  • Rongione AJ, Kusske AM, Kwan K, Ashley SW, Reber HA, McFadden DW. Interleukin-10 protects against lethality of intra-abdominal infection and sepsis. J Gastrointest Surg 2000; 4:70-6. PubMed
  • Patel AG, Reber PU, Toyama MT, Ashley SW, Reber HA. Effect of pancreaticojejunostomy on fibrosis, pancreatic blood flow, and interstitial pH in chronic pancreatitis: a feline model. Ann Surg 1999; 230:672-9. PubMed
  • Reber PU, Patel AG, Toyama MT, Ashley SW, Reber HA. Feline model of chronic obstructive pancreatitis: effects of acute pancreatic duct decompression on blood flow and interstitial pH. Scand J Gastroenterol 1999; 34:439-44. PubMed
  • Lane JS, Whang EE, Rigberg DA, Hines OJ, Kwan D, Zinner MJ, McFadden DW, Diamond J, Ashley SW. Paracellular glucose transport plays a minor role in the unanesthetized dog. Am J Physiol 1999; 276:G789-94. PubMed
  • Reber PU, Lewis MP, Patel AG, Andren-Sandberg A, Ashley SW, Reber HA. Ethanol-mediated neutrophil extravasation in feline pancreas. Dig Dis Sci 1999; 43:2610-5. PubMed
  • Lane JS, Kwan D, Chandler CF, Alexander P, Todd KE, McFadden DW, Ashley SW. Diverting loop versus end ileostomy during ileoanal pullthrough procedure for ulcerative colitis. Am Surg 1998; 64:979-82. PubMed
  • Reber PU, Patel AG, Lewis MP, Ashley SW, Reber HA. Stenting does not decompress the pancreatic duct as effectively as surgery in experimental chronic pancreatitis. Surgery 1998; 124:561-7. PubMed
  • Lewis MP, Reber PU, Kusske AM, Toyama MT, Todd KE, Ashley SW, Reber HA. Intragastric alcohol causes endothelin release from feline pancreas. Dig Dis Sci 1998; 43:927-30. PubMed
  • Lewis MP, Reber HA, Ashley SW. Pancreatic blood flow and its role in the pathophysiology of pancreatitis. J Surg Res 1998; 75:81-9. PubMed
  • Todd KE, Lewis MP, Gloor B, Kusske AM, Ashley SW, Reber HA. Management decisions for unusual periampullary tumors. Am Surg 1997; 63:927-32. PubMed
  • Todd KE, Lewis MP, Gloor B, Lane JS, Ashley SW, Reber HA. An ETa/ETb endothelin antagonist ameliorates systemic inflammation in a murine model of acute hemorrhagic pancreatitis. Surgery 1997; 122:443-9; discussion 449-50. PubMed
  • Lane JS, Todd KE, Lewis MP, Gloor B, Ashley SW, Reber HA, McFadden DW, Chandler CF. Interleukin-10 reduces the systemic inflammatory response in a murine model of intestinal ischemia/reperfusion. Surgery 1997; 122:288-94. PubMed
  • Rongione AJ, Kusske AM, Ashley SW, Reber HA, McFadden DW. Interleukin-10 prevents early cytokine release in severe intraabdominal infection and sepsis. J Surg Res 1997; 70:107-12. PubMed
  • Barquist ES, Apple SK, Jensen DM, Ashley SW. Jejunal lymphangioma. An unusual cause of chronic gastrointestinal bleeding. Dig Dis Sci 1997; 42:1179-83. PubMed
  • Whang EE, Hines OJ, Reeve JR, Grandt D, Moser JA, Bilchik AJ, Zinner MJ, McFadden DW, Ashley SW. Antisecretory mechanisms of peptide YY in rat distal colon. Dig Dis Sci 1997; 42:1121-7. PubMed
  • Liu CD, Newton TR, Zinner MJ, Ashley SW, McFadden DW. Intraluminal peptide YY induces colonic absorption in vivo. Dis Colon Rectum 1997; 40:478-82. PubMed
  • Rongione AJ, Kusske AM, Reber HA, Ashley SW, McFadden DW. Interleukin-10 Reduces Circulating Levels of Serum Cytokines in Experimental Pancreatitis. J Gastrointest Surg 1998; 1:159-166. PubMed
  • Rongione AJ, Kusske AM, Kwan K, Ashley SW, Reber HA, McFadden DW. Interleukin 10 reduces the severity of acute pancreatitis in rats. Gastroenterology 1997; 112:960-7. PubMed
  • Toyama MT, Patel AG, Nguyen T, Ashley SW, Reber HA. Effect of ethanol on pancreatic interstitial pH and blood flow in cats with chronic pancreatitis. Ann Surg 1997; 225:223-8. PubMed
  • Thompson JE, Ashley SW. Subcapsular hematoma of the spleen associated with acute pancreatitis. Surgery 1997; 121:231-3. PubMed
  • Dunn JC, Parungo CP, Fonkalsrud EW, McFadden DW, Ashley SW. Epidermal growth factor selectively enhances functional enterocyte adaptation after massive small bowel resection. J Surg Res 1997; 67:90-3. PubMed
  • Whang EE, Dunn JC, Mahanty H, McFadden DW, Zinner MJ, Ashley SW. Endotoxin inhibitor prevents sepsis-induced alterations in intestinal ion transport. Am J Surg 1996; 172:341-4. PubMed
  • Kusske AM, Rongione AJ, Ashley SW, McFadden DW, Reber HA. Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice. Surgery 1996; 120:284-8; discussion 289. PubMed
  • Patel AG, McFadden DW, Hines OJ, Reber HA, Ashley SW. Palliation for pancreatic cancer. Feasibility of laparoscopic cholecystojejunostomy and gastrojejunostomy in a porcine model. Surg Endosc 1996; 10:639-43. PubMed
  • Liu CD, Rongione AJ, Shin MS, Ashley SW, McFadden DW. Epidermal growth factor improves intestinal adaptation during somatostatin administration in vivo. J Surg Res 1996; 63:163-8. PubMed
  • Liu CD, Aloia T, Adrian TE, Newton TR, Bilchik AJ, Zinner MJ, Ashley SW, McFadden DW. Peptide YY: a potential proabsorptive hormone for the treatment of malabsorptive disorders. Am Surg 1996; 62:232-6. PubMed
  • Liu CD, Hines OJ, Newton TR, Adrian TE, Zinner MJ, Ashley SW, McFadden DW. Cholecystokinin mediation of colonic absorption via peptide YY: foregut-hindgut axis. World J Surg 1996; 20:221-7. PubMed
  • Whang EE, Dunn JC, Joffe H, Mahanty H, Zinner MJ, McFadden DW, Ashley SW. Enterocyte functional adaptation following intestinal resection. J Surg Res 1996; 60:370-4. PubMed
  • Whang EE, Dunn JC, Liu CD, Newton T, Zinner MJ, McFadden DW, Ashley SW. Amiloride inhibits meal-stimulated colonic absorption. J Surg Res 1996; 60:303-6. PubMed
  • Toyama MT, Lewis MP, Kusske AM, Reber PU, Ashley SW, Reber HA. Ischaemia-reperfusion mechanisms in acute pancreatitis. Scand J Gastroenterol Suppl 1996; 219:20-3. PubMed
  • Liu CD, Rolandelli R, Ashley SW, Evans B, Shin M, McFadden DW. Laparoscopic surgery for inflammatory bowel disease. Am Surg 1995; 61:1054-6. PubMed
  • Patel AG, Toyama MT, Alvarez C, Nguyen TN, Reber PU, Ashley SW, Reber HA. Pancreatic interstitial pH in human and feline chronic pancreatitis. Gastroenterology 1995; 109:1639-45. PubMed
  • Ashley SW. Sterile pancreatic necrosis: is operation necessary? J Am Coll Surg 1995; 181:363-4. PubMed
  • Reber HA, Ashley SW, McFadden D. Curative treatment for pancreatic neoplasms. Radical resection. Surg Clin North Am 1995; 75:905-12. PubMed
  • Patel AG, Toyama MT, Kusske AM, Alexander P, Ashley SW, Reber HA. Pylorus-preserving Whipple resection for pancreatic cancer. Is it any better? Arch Surg 1995; 130:838-42; discussion 842-3. PubMed
  • Liu CD, Hines OJ, Whang EE, Balasubramaniam A, Newton TR, Zinner MJ, Ashley SW, McFadden DW. A novel synthetic analog of peptide YY, BIM-43004, given intraluminally, is proabsorptive. J Surg Res 1995; 59:80-4. PubMed
  • Hines OJ, Bilchik AJ, McFadden DW, Rodgers PJ, Bautista N, Zinner MJ, Ashley SW. Na+/H+ exchange mediates postprandial ileal water and electrolyte transport. Dig Dis Sci 1995; 40:774-80. PubMed
  • Patel AG, Toyama MT, Nguyen TN, Cohen GA, Ignarro LJ, Reber HA, Ashley SW. Role of nitric oxide in the relationship of pancreatic blood flow and exocrine secretion in cats. Gastroenterology 1995; 108:1215-20. PubMed
  • Bilchik AJ, Hines OJ, Adrian TE, Skotzko MJ, McFadden DW, Zinner MJ, Ashley SW. Early regional expression and secretion of peptide YY and enteroglucagon after massive resection of small bowel. J Am Coll Surg 1995; 180:417-26. PubMed
  • Hines OJ, Bilchik AJ, Ashley SW, Whang EE, Liu CD, Zinner MJ, McFadden DW. Amino acids mediate postprandial jejunal proabsorption. J Surg Res 1995; 58:81-5. PubMed
  • Liu CD, Hines OJ, Whang EE, Laird EC, Skotzko MJ, Zinner MJ, Ashley SW, McFadden DW. Pancreatic peptide YY mRNA levels increase during adaptation after small intestinal resection. J Surg Res 1995; 58:6-11. PubMed
  • Bilchik AJ, Hines OJ, Ashley SW, Adrian TE, Walsh J, Wong H, Liu CD, Zinner MJ, McFadden DW. Peptide YY immunoneutralization inhibits meal-induced absorption in vivo. Surgery 1994; 116:1153-7; discussion 1157-8. PubMed
  • Hines OJ, Bilchik AJ, McFadden DW, Skotzko MJ, Whang EE, Zinner MJ, Ashley SW. Up-regulation of Na+,K+ adenosine triphosphatase after massive intestinal resection. Surgery 1994; 116:401-7; discussion 408. PubMed
  • Alvarez C, Hunt K, Ashley SW, Reber HA. Emphysematous cholecystitis after ERCP. Dig Dis Sci 1994; 39:1719-23. PubMed
  • Hines OJ, Bilchik AJ, Zinner MJ, Skotzko MJ, Moser AJ, McFadden DW, Ashley SW. Adaptation of the Na+/glucose cotransporter following intestinal resection. J Surg Res 1994; 57:22-7. PubMed
  • Bilchik AJ, Hines OJ, Zinner MJ, Adrian TE, Berger JJ, Ashley SW, McFadden DW. Peptide YY augments postprandial small intestinal absorption in the conscious dog. Am J Surg 1994; 167:570-4. PubMed
  • Ashley SW, Schwarz M, Alvarez C, Nguyen TN, Vdovenko A, Reber HA. Pancreatic interstitial pH regulation: effects of secretory stimulation. Surgery 1994; 115:503-9. PubMed
  • Ashley SW, Sherman S, Reber HA. Endoscopic measurement of pancreatic blood flow. Gastrointest Endosc Clin N Am 1994; 4:369-82. PubMed
  • Ashley SW, Reber HA. Pancreatic duct permeability and pancreatitis. Pancreas 1993; 8:740-1. PubMed
  • Bilchik AJ, Hines OJ, Adrian TE, McFadden DW, Berger JJ, Zinner MJ, Ashley SW. Peptide YY is a physiological regulator of water and electrolyte absorption in the canine small bowel in vivo. Gastroenterology 1993; 105:1441-8. PubMed
  • Sherman S, Alvarez C, Robert M, Ashley SW, Reber HA, Lehman GA. Polyethylene pancreatic duct stent-induced changes in the normal dog pancreas. Gastrointest Endosc 1993; 39:658-64. PubMed
  • Alvarez C, Livingston EH, Ashley SW, Schwarz M, Reber HA. Cost-benefit analysis of the work-up for pancreatic cancer. Am J Surg 1993; 165:53-8; discussion 58-60. PubMed
  • Reber HA, Karanjia ND, Alvarez C, Widdison AL, Leung FW, Ashley SW, Lutrin FJ. Pancreatic blood flow in cats with chronic pancreatitis. Gastroenterology 1992; 103:652-9. PubMed
  • Soper NJ, Stockmann PT, Dunnegan DL, Ashley SW. Laparoscopic cholecystectomy. The new 'gold standard'? Arch Surg 1992; 127:917-21; discussion 921-3. PubMed
  • Soybel DI, Ashley SW, Cheung LY. Basolateral K+ conductances in surface epithelium of Necturus antrum: effects of Ca2+ and divalent cations. Am J Physiol 1992; 262:G651-9. PubMed
  • Soper NJ, Barteau JA, Clayman RV, Ashley SW, Dunnegan DL. Comparison of early postoperative results for laparoscopic versus standard open cholecystectomy. Surg Gynecol Obstet 1992; 174:114-8. PubMed
  • Aliperti G, Edmundowicz SA, Soper NJ, Ashley SW. Combined endoscopic sphincterotomy and laparoscopic cholecystectomy in patients with choledocholithiasis and cholecystolithiasis. Ann Intern Med 1991; 115:783-5. PubMed
  • Radford DM, Ashley SW, Wells SA, Gerhard DS. Loss of heterozygosity of markers on chromosome 11 in tumors from patients with multiple endocrine neoplasia syndrome type 1. Cancer Res 1990; 50:6529-33. PubMed
  • Ashley SW, Soybel DI, Moore CD, Cheung LY. Effects of aspirin and acetic acid on intracellular pH in necturus gastric mucosa. Am J Surg 1988; 157:66-73. PubMed
  • Ashley SW, Wells SA. Tumors of the small intestine. Semin Oncol 1988; 15:116-28. PubMed
  • Soybel DI, Ashley SW, Cheung LY. Effects of platelet-activating factor on canine gastric mucosal blood flow and permeability to luminal acid. Am J Surg 1987; 155:180-5. PubMed
  • Soybel DI, Ashley SW, DeSchryver-Kecskemeti K, Cheung LY. Effects of luminal hyperosmolality on cellular and paracellular ion transport pathways in necturus antrum. Gastroenterology 1987; 93:456-65. PubMed
  • Ashley SW, Soybel DI, Moore CD, Cheung LY. Intracellular pH (pHi) in gastric surface epithelium is more susceptible to serosal than mucosal acidification. Surgery 1987; 102:371-9. PubMed
  • Cheung LY, Ashley SW. Gastric blood flow and mucosal defense mechanisms. Clin Invest Med 1987; 10:201-8. PubMed
  • Soybel DI, Wan YL, Ashley SW, Yan ZY, Ordway FS, Cheung LY. Endoscopic measurements of canine colonic mucosal blood flow using hydrogen gas clearance. Gastroenterology 1987; 92:1045-50. PubMed
  • Swarm RA, Ashley SW, Soybel DI, Ordway FS, Cheung LY. Protective effect of exogenous phospholipid on aspirin-induced gastric mucosal injury. Am J Surg 1986; 153:48-53. PubMed
  • Soybel DI, Ashley SW, Swarm RA, Moore CD, Cheung LY. Effects of luminal salt concentration on electrical pathways in Necturus antrum. Am J Physiol 1986; 252:G19-27. PubMed
  • Soybel DI, Ashley SW, Yan ZY, Swarm RA, Cheung LY. Regional gastric mucosal blood flow after parietal cell vagotomy in dogs. Surgery 1986; 100:167-74. PubMed
  • Ashley SW, Soybel DI, Cheung LY. Measurements of intracellular pH in Necturus antral mucosa by microelectrode technique. Am J Physiol 1986; 250:G625-32. PubMed
  • Ashley SW, Soybel DI, Cheung LY. Effect of 16,16-dimethyl prostaglandin E2 on gastric epithelial cell membrane potentials and resistances. Surgery 1985; 98:166-73. PubMed
  • Soybel DI, Ashley SW, Yan ZY, Cheung LY. Comparison of gastric mucosal blood flow as measured by H2 gas clearance and microspheres during secretory stimulation and inhibition. Surgery 1985; 98:174-82. PubMed
  • Ashley SW, Soybel DI, De L, Cheung LY. Microelectrode studies of Necturus antral mucosa. II. Equivalent circuit analysis. Am J Physiol 1985; 248:G574-9. PubMed
  • Ashley SW, Yan ZY, Soybel DI, Cheung LY. Endoscopic measurements of gastric mucosal blood flow in dogs. J Surg Res 1985; 38:416-23. PubMed
  • Ashley SW, Sonnenschein LA, Cheung LY. Focal gastric mucosal blood flow at the site of aspirin-induced ulceration. Am J Surg 1984; 149:53-9. PubMed
  • Cheung LY, De L, Ashley SW. Intracellular microelectrode studies of Necturus antral mucosa. Effect of aspirin on cell membrane potentials. Gastroenterology 1984; 88:261-8. PubMed
  • Ashley SW, Cheung LY. New diagnostic techniques in hepatobiliary disease. Surg Annu 1984; 17:41-67. PubMed
  • Ashley SW, Cheung LY. Measurements of gastric mucosal blood flow by hydrogen gas clearance. Am J Physiol 1984; 247:G339-45. PubMed
  • Cheung LY, De L, Ashley SW. Effect of aspirin on epithelial cell membrane potentials of gastric fundic mucosa. Surgery 1984; 96:171-8. PubMed
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