Photo of Stefan A. Carp,  PhD

Stefan A. Carp, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 643-2230


carp@nmr.mgh.harvard.edu

Stefan A. Carp, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Radiology, Harvard Medical School
  • Assistant in Biomedical Engineering, Radiology / Martinos Center, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on the development of novel optical instrumentation for non-invasive tissue monitoring and the translation of these techqniques for clinical use. In particular, I am interested in the application of near-infrared diffuse optical tomography techniques for breast cancer diagnosis and chemotherapy guidance. We have recently shown that dynamic changes in tissue blood volume during fractional mammographic-like compression can be used to assess the early response of malignant lesions to neoadjuvant chemotherapy. I am currently preparing to conduct a follow-up study, that uses a multi-modal optical imaging system combined with digital breast tomosynthesis to characterize the outcome early prediction performance of dynamic optical biomarkers assessed during a multi-stage breast compression maneuver for HER2+ and TNBC patients undergoing NACT.

Publications

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  • Zimmermann BB, Deng B, Singh B, Martino M, Selb J, Fang Q, Sajjadi AY, Cormier J, Moore RH, Kopans DB, Boas DA, Saksena MA, Carp SA. Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis. J Biomed Opt 2017; 22:46008. PubMed
  • Sajjadi AY, Isakoff SJ, Deng B, Singh B, Wanyo CM, Fang Q, Specht MC, Schapira L, Moy B, Bardia A, Boas DA, Carp SA. Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI). Biomed Opt Express 2017; 8:555-569. PubMed
  • Tromberg BJ, Zhang Z, Leproux A, O'Sullivan TD, Cerussi AE, Carpenter PM, Mehta RS, Roblyer D, Yang W, Paulsen KD, Pogue BW, Jiang S, Kaufman PA, Yodh AG, Chung SH, Schnall M, Snyder BS, Hylton N, Boas DA, Carp SA, Isakoff SJ, Mankoff D, . Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging. Cancer Res 2016. PubMed
  • Carp SA, Sajjadi AY, Wanyo CM, Fang Q, Specht MC, Schapira L, Moy B, Bardia A, Boas DA, Isakoff SJ. Hemodynamic signature of breast cancer under fractional mammographic compression using a dynamic diffuse optical tomography system. Biomed Opt Express 2014; 4:2911-24. PubMed
  • Fang Q, Selb J, Carp SA, Boverman G, Miller EL, Brooks DH, Moore RH, Kopans DB, Boas DA. Combined optical and X-ray tomosynthesis breast imaging. Radiology 2010; 258:89-97. PubMed
  • Fang Q,Carp SA,Selb J,Boverman G,Zhang Q,Kopans DB,Moore RH,Miller EL,Brooks DH,Boas DA. Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression. IEEE Trans Med Imaging 2009; 28:30-42. PubMed
  • Boverman G, Fang Q, Carp SA, Miller EL, Brooks DH, Selb J, Moore RH, Kopans DB, Boas DA. Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography. Phys Med Biol 2007; 52:3619-41. PubMed
  • Carp SA, Kauffman T, Fang Q, Rafferty E, Moore R, Kopans D, Boas D. Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. J Biomed Opt 2007; 11:064016. PubMed