Photo of Stephan E. Maier,  MD, PhD

Stephan E. Maier, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-5065
Fax: (617) 264-5275

Stephan E. Maier, MD, PhD

Brigham And Women's Hospital


  • Lecturer, Radiology, Harvard Medical School
  • Associate Professor, Radiology, Brigham And Women's Hospital

Research Abstract

At Brigham and Women's Hospital we discovered and developed a new magnetic resonance (MR)

diffusion imaging technique called Line Scan Diffusion Imaging (LSDI), which can be implemented

on conventional MR hardware. By measuring the directional dependence of diffusion, we have been

able to produce images which show the white matter fiber tracts of the brain in great detail. We have

used fiber mapping to visualize and quantify the development of fiber tracts in neonates and the

destruction of fiber tracts by brain tumors. In human diffusion brain scans we found that, with higher

diffusion weighting than usual, signal attenuation is described better with a biexponential model, rather

than the commonly used monoexponential model. Our initial findings indicate that maps generated

from data of such biexponential fits, are useful for the differentiation and delineation of normal, edematous,

and tumorous tissue without contrast agents and thus, may provide additional information not accessible

with conventional MR contrast agents.


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  • Zhang SH, Maier SE, Panych LP. Improved spatial localization in magnetic resonance spectroscopic imaging with two-dimensional PSF-Choice encoding. J Magn Reson 2018; 290:18-28. PubMed
  • Langkilde F, Kobus T, Fedorov A, Dunne R, Tempany C, Mulkern RV, Maier SE. Evaluation of fitting models for prostate tissue characterization using extended-range b-factor diffusion-weighted imaging. Magn Reson Med 2017. PubMed
  • Fedorov A, Tuncali K, Panych LP, Fairhurst J, Hassanzadeh E, Seethamraju RT, Tempany CM, Maier SE. Segmented diffusion-weighted imaging of the prostate: Application to transperineal in-bore 3T MR image-guided targeted biopsy. Magn Reson Imaging 2016; 34:1146-1154. PubMed
  • Yamauchi FI, Penzkofer T, Fedorov A, Fennessy FM, Chu R, Maier SE, Tempany CM, Mulkern RV, Panych LP. Prostate cancer discrimination in the peripheral zone with a reduced field-of-view T(2)-mapping MRI sequence. Magn Reson Imaging 2015. PubMed
  • Hegde JV, Mulkern RV, Panych LP, Fennessy FM, Fedorov A, Maier SE, Tempany CM. Multiparametric MRI of prostate cancer: an update on state-of-the-art techniques and their performance in detecting and localizing prostate cancer. J Magn Reson Imaging 2013; 37:1035-54. PubMed
  • Yoshizako T, Wada A, Uchida K, Hara S, Igawa M, Kitagaki H, Maier SE. Apparent diffusion coefficient of line scan diffusion image in normal prostate and prostate cancer-comparison with single-shot echo planner image. Magn Reson Imaging 2010; 29:106-10. PubMed
  • Maier SE, Sun Y, Mulkern RV. Diffusion imaging of brain tumors. NMR Biomed 2010; 23:849-64. PubMed
  • Mulkern RV, Haker SJ, Maier SE. On high b diffusion imaging in the human brain: ruminations and experimental insights. Magn Reson Imaging 2009; 27:1151-62. PubMed
  • Maier SE, Mulkern RV. Biexponential analysis of diffusion-related signal decay in normal human cortical and deep gray matter. Magn Reson Imaging 2008; 26:897-904. PubMed
  • Lee Y, Rowe J, Eskue K, West JR, Maier SE. Alcohol exposure on postnatal day 5 induces Purkinje cell loss and evidence of Purkinje cell degradation in lobule I of rat cerebellum. Alcohol 2008; 42:295-302. PubMed
  • Maeda M, Maier SE. Usefulness of diffusion-weighted imaging and the apparent diffusion coefficient in the assessment of head and neck tumors. J Neuroradiol 2008; 35:71-8. PubMed
  • Roth Y, Ocherashvilli A, Daniels D, Ruiz-Cabello J, Maier SE, Orenstein A, Mardor Y. Quantification of water compartmentation in cell suspensions by diffusion-weighted and T(2)-weighted MRI. Magn Reson Imaging 2007; 26:88-102. PubMed
  • Sizonenko SV, Camm EJ, Garbow JR, Maier SE, Inder TE, Williams CE, Neil JJ, Huppi PS. Developmental changes and injury induced disruption of the radial organization of the cortex in the immature rat brain revealed by in vivo diffusion tensor MRI. Cereb Cortex 2007; 17:2609-17. PubMed
  • Suzuki C, Maeda M, Matsumine A, Matsubara T, Taki W, Maier SE, Takeda K. Apparent diffusion coefficient of subcutaneous epidermal cysts in the head and neck comparison with intracranial epidermoid cysts. Acad Radiol 2007; 14:1020-8. PubMed
  • Mulkern RV, Haker SJ, Maier SE. Complimentary aspects of diffusion imaging and fMRI: II. Elucidating contributions to the fMRI signal with diffusion sensitization. Magn Reson Imaging 2007; 25:939-52. PubMed
  • Maier SE. Examination of spinal cord tissue architecture with magnetic resonance diffusion tensor imaging. Neurotherapeutics 2007; 4:453-9. PubMed
  • Maeda M, Matsumine A, Kato H, Kusuzaki K, Maier SE, Uchida A, Takeda K. Soft-tissue tumors evaluated by line-scan diffusion-weighted imaging: influence of myxoid matrix on the apparent diffusion coefficient. J Magn Reson Imaging 2007; 25:1199-204. PubMed