Photo of Stephanie Mohr,  PhD

Stephanie Mohr, PhD

Harvard Medical School


Phone: (617) 432-5626


stephanie_mohr@hms.harvard.edu

Stephanie Mohr, PhD

Harvard Medical School

DF/HCC ASSOCIATIONS

  • Member, Center Scientific Council

Publications

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  • Hu Y, Comjean A, Perrimon N, Mohr SE. The Drosophila Gene Expression Tool (DGET) for expression analyses. BMC Bioinformatics 2017; 18:98. PubMed
  • Hu Y, Comjean A, Roesel C, Vinayagam A, Flockhart I, Zirin J, Perkins L, Perrimon N, Mohr SE. FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2017 update. Nucleic Acids Res 2016; 45:D672-D678. PubMed
  • Housden BE, Muhar M, Gemberling M, Gersbach CA, Stainier DY, Seydoux G, Mohr SE, Zuber J, Perrimon N. Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. Nat Rev Genet 2016; 18:24-40. PubMed
  • Vinayagam A, Kulkarni MM, Sopko R, Sun X, Hu Y, Nand A, Villalta C, Moghimi A, Yang X, Mohr SE, Hong P, Asara JM, Perrimon N. An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling. Cell Rep 2016; 16:3062-74. PubMed
  • Mohr SE, Hu Y, Ewen-Campen B, Housden BE, Viswanatha R, Perrimon N. CRISPR guide RNA design for research applications. FEBS J 2016. PubMed
  • Perkins LA, Holderbaum L, Tao R, Hu Y, Sopko R, McCall K, Yang-Zhou D, Flockhart I, Binari R, Shim HS, Miller A, Housden A, Foos M, Randkelv S, Kelley C, Namgyal P, Villalta C, Liu LP, Jiang X, Huan-Huan Q, Wang X, Fujiyama A, Toyoda A, Ayers K, Blum A, Czech B, Neumuller R, Yan D, Cavallaro A, Hibbard K, Hall D, Cooley L, Hannon GJ, Lehmann R, Parks A, Mohr SE, Ueda R, Kondo S, Ni JQ, Perrimon N. The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. Genetics 2015. PubMed
  • Housden BE, Valvezan AJ, Kelley C, Sopko R, Hu Y, Roesel C, Lin S, Buckner M, Tao R, Yilmazel B, Mohr SE, Manning BD, Perrimon N. Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi. Sci Signal 2015; 8:rs9. PubMed
  • Mohr SE, Hu Y, Rudd K, Buckner M, Gilly Q, Foster B, Sierzputowska K, Comjean A, Ye B, Perrimon N. Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells. 2015; 5:1919-24. PubMed
  • Hu Y, Comjean A, Perkins LA, Perrimon N, Mohr SE. GLAD: an Online Database of Gene List Annotation for Drosophila. J Genomics 2015; 3:75-81. PubMed
  • Mohr SE, Smith JA, Shamu CE, Neumüller RA, Perrimon N. RNAi screening comes of age: improved techniques and complementary approaches. Nat Rev Mol Cell Biol 2014; 15:591-600. PubMed
  • Mohr SE. RNAi screening in Drosophila cells and in vivo. Methods 2014; 68:82-8. PubMed
  • Mohr SE, Hu Y, Kim K, Housden BE, Perrimon N. Resources for functional genomics studies in Drosophila melanogaster. Genetics 2014. PubMed
  • Vinayagam A, Zirin J, Roesel C, Hu Y, Yilmazel B, Samsonova AA, Neumüller RA, Mohr SE, Perrimon N. Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Nat Methods 2013; 11:94-9. PubMed
  • Yilmazel B, Hu Y, Sigoillot F, Smith JA, Shamu CE, Perrimon N, Mohr SE. Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis. BMC Bioinformatics 2014; 15:192. PubMed
  • Ren X, Sun J, Housden BE, Hu Y, Roesel C, Lin S, Liu LP, Yang Z, Mao D, Sun L, Wu Q, Ji JY, Xi J, Mohr SE, Xu J, Perrimon N, Ni JQ. Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A 2013; 110:19012-7. PubMed
  • Hu Y, Roesel C, Flockhart I, Perkins L, Perrimon N, Mohr SE. UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. Genetics 2013; 195:37-45. PubMed
  • Hu Y, Sopko R, Foos M, Kelley C, Flockhart I, Ammeux N, Wang X, Perkins L, Perrimon N, Mohr SE. FlyPrimerBank: an online database for Drosophila melanogaster gene expression analysis and knockdown evaluation of RNAi reagents. 2013; 3:1607-16. PubMed
  • Vinayagam A, Hu Y, Kulkarni M, Roesel C, Sopko R, Mohr SE, Perrimon N. Protein complex-based analysis framework for high-throughput data sets. Sci Signal 2013; 6:rs5. PubMed
  • Bergwitz C, Wee MJ, Sinha S, Huang J, DeRobertis C, Mensah LB, Cohen J, Friedman A, Kulkarni M, Hu Y, Vinayagam A, Schnall-Levin M, Berger B, Perkins LA, Mohr SE, Perrimon N. Genetic determinants of phosphate response in Drosophila. PLoS ONE 2013; 8:e56753. PubMed
  • Neumüller RA, Wirtz-Peitz F, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJ, Bellen HJ, Mohr SE, Perrimon N. Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Genetics 2012; 190:931-40. PubMed
  • Flockhart IT, Booker M, Hu Y, McElvany B, Gilly Q, Mathey-Prevot B, Perrimon N, Mohr SE. FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update. Nucleic Acids Res 2011; 40:D715-9. PubMed
  • Mohr SE, Perrimon N. RNAi screening: new approaches, understandings, and organisms. 2012. PubMed
  • Booker M, Samsonova AA, Kwon Y, Flockhart I, Mohr SE, Perrimon N. False negative rates in Drosophila cell-based RNAi screens: a case study. BMC Genomics 2011; 12:50. PubMed
  • Hu Y, Flockhart I, Vinayagam A, Bergwitz C, Berger B, Perrimon N, Mohr SE. An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics 2011; 12:357. PubMed
  • Cormier CY, Mohr SE, Zuo D, Hu Y, Rolfs A, Kramer J, Taycher E, Kelley F, Fiacco M, Turnbull G, LaBaer J. Protein Structure Initiative Material Repository: an open shared public resource of structural genomics plasmids for the biological community. Nucleic Acids Res 2009; 38:D743-9. PubMed
  • Myrick KV, Huet F, Mohr SE, Alvarez-García I, Lu JT, Smith MA, Crosby MA, Gelbart WM. Large-scale functional annotation and expanded implementations of the P{wHy} hybrid transposon in the Drosophila melanogaster genome. Genetics 2009; 182:653-60. PubMed
  • Rolfs A, Montor WR, Yoon SS, Hu Y, Bhullar B, Kelley F, McCarron S, Jepson DA, Shen B, Taycher E, Mohr SE, Zuo D, Williamson J, Mekalanos J, Labaer J. Production and sequence validation of a complete full length ORF collection for the pathogenic bacterium Vibrio cholerae. Proc Natl Acad Sci U S A 2008; 105:4364-9. PubMed
  • Murthy T, Rolfs A, Hu Y, Shi Z, Raphael J, Moreira D, Kelley F, McCarron S, Jepson D, Taycher E, Zuo D, Mohr SE, Fernandez M, Brizuela L, LaBaer J. A full-genomic sequence-verified protein-coding gene collection for Francisella tularensis. PLoS ONE 2007; 2:e577. PubMed
  • Zuo D, Mohr SE, Hu Y, Taycher E, Rolfs A, Kramer J, Williamson J, LaBaer J. PlasmID: a centralized repository for plasmid clone information and distribution. Nucleic Acids Res 2007; 35:D680-4. PubMed
  • Taycher E, Rolfs A, Hu Y, Zuo D, Mohr SE, Williamson J, Labaer J. A novel approach to sequence validating protein expression clones with automated decision making. BMC Bioinformatics 2007; 8:198. PubMed
  • Mohr SE, Gelbart WM. Using the P[wHy] hybrid transposable element to disrupt genes in region 54D-55B in Drosophila melanogaster. Genetics 2002; 162:165-76. PubMed
  • Mohr SE, Boswell RE. Genetic analysis of Drosophila melanogaster polytene chromosome region 44D-45F: loci required for viability and fertility. Genetics 2002; 160:1503-10. PubMed
  • Mohr SE, Dillon ST, Boswell RE. The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis. Genes Dev 2001; 15:2886-99. PubMed
  • Mohr SE, Boswell RE. Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential gene in Drosophila melanogaster. Gene 1999; 229:109-16. PubMed
  • Newmark PA, Mohr SE, Gong L, Boswell RE. mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila. Development 1997; 124:3197-207. PubMed
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