Photo of Susan R. Rittling,  PhD

Susan R. Rittling, PhD

The Forsyth Institute

The Forsyth Institute
Phone: (617) 892-8450
Fax: (617) 892-8303


srittling@forsyth.org

Susan R. Rittling, PhD

The Forsyth Institute

EDUCATIONAL TITLES

  • Instructor, Developmental Biology, Harvard School Of Dental Medicine
  • Senior Research Investigator, Cytokine Biology, The Forsyth Institute

DF/HCC PROGRAM AFFILIATION

Research Abstract

For many years my research has focused on the function and mechanism of action of the secreted phosphoprotein osteopontin, which has roles in cancer biology, immunology and bone biology, and has led my work into these different but overlapping fields. I am considered an expert in the field of osteopontin, regularly participate in organizing meetings focused on this protein, and have authored numerous reviews on this topic. My current research focus is on the role of osteopontin and its receptors (a series of integrins) in regulation of the innate immune response to endodontic infection. Specifically, we are focused on the role of osteopontin in the regulation of neutrophil chemotaxis, and have described a novel role in the regulation of CXCR2 function, internalization and trafficking. Since migration of immune and tumor cells underlie many forms of pathology associated with elevated OPN expression, these studies may have wide implications for the role of osteopontin in these diseases, including metastatic disease.

Publications

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  • Rittling SR, Singh R. Osteopontin in Immune-mediated Diseases. J. Dent. Res. 2015; 94:1638-45. PubMed
  • Matsui A, Stephens D, Kantarci A, Rittling SR. Early Cytokine Response to Infection with Pathogenic vs Non-Pathogenic Organisms in a Mouse Model of Endodontic Infection. PLoS ONE 2015; 10:e0132752. PubMed
  • Hui T, Sørensen ES, Rittling SR. Osteopontin binding to the alpha 4 integrin requires highest affinity integrin conformation, but is independent of post-translational modifications of osteopontin. Matrix Biol 2015; 41:19-25. PubMed
  • Matsui A, Jin JO, Johnston CD, Yamazaki H, Houri-Haddad Y, Rittling SR. Pathogenic bacterial species associated with endodontic infection evade innate immune control by disabling neutrophils. Infect Immun 2014; 82:4068-79. PubMed
  • Diao H, Liu X, Wu Z, Kang L, Cui G, Morimoto J, Denhardt DT, Rittling S, Iwakura Y, Uede T, Li L. Osteopontin regulates interleukin-17 production in hepatitis. Cytokine 2012; 60:129-37. PubMed
  • Morishita M, Ono N, Miyai K, Nakagawa T, Hanyu R, Nagao M, Kamolratanakul P, Notomi T, Rittling SR, Denhardt DT, Kronenberg HM, Ezura Y, Hayata T, Nakamoto T, Noda M. Osteopontin deficiency enhances parathyroid hormone/ parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology. 2011; 43:196-200. PubMed
  • Rittling SR. Osteopontin in macrophage function. Expert Rev Mol Med 2011; 13:e15. PubMed
  • Zhang ZX, Shek K, Wang S, Huang X, Lau A, Yin Z, Sun H, Liu W, Garcia B, Rittling S, Jevnikar AM. Osteopontin expressed in tubular epithelial cells regulates NK cell-mediated kidney ischemia reperfusion injury. J Immunol 2010; 185:967-73. PubMed
  • Shimizu S, Okuda N, Kato N, Rittling SR, Shinomiya K, Muneta T, Denhardt DT, Noda M, Tsuji K, Asou Y. Osteopontin-deficiency impairs wear debris-induced osteolysis via the regulation of cytokine secretion from macrophage. Arthritis Rheum 2010; 62:1329-37. PubMed
  • Fujita N, Fujita S, Okada Y, Fujita K, Kitano A, Yamanaka O, Miyamoto T, Kon S, Uede T, Rittling SR, Denhardt DT, Saika S. Impaired angiogenic response in the corneas of mice lacking osteopontin. Invest Ophthalmol Vis Sci 2010; 51:790-4. PubMed
  • Monfoulet L, Malaval L, Aubin JE, Rittling SR, Gadeau AP, Fricain JC, Chassande O. Bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing. Bone 2010; 46:447-52. PubMed
  • Rittling SR, Zetterberg C, Yagiz K, Skinner S, Suzuki N, Fujimura A, Sasaki H. Protective role of osteopontin in endodontic infection. Immunology 2009; 129:105-14. PubMed
  • Kurokawa M, Konno S, Takahashi A, Plunkett B, Rittling SR, Matsui Y, Kon S, Morimoto J, Uede T, Matsukura S, Kokubu F, Adachi M, Nishimura M, Huang SK. Regulatory role of DC-derived osteopontin in systemic allergen sensitization. Eur J Immunol 2009; 39:3323-30. PubMed
  • Kwok S, Rittling SR, Partridge NC, Benson CS, Thiyagaraj M, Srinivasan N, Selvamurugan N. Transforming growth factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells. J Cell Biochem 2009; 108:408-14. PubMed
  • Yagiz K,Rittling SR. Both cell-surface and secreted CSF-1 expressed by tumor cells metastatic to bone can contribute to osteoclast activation. Exp Cell Res 2009; 315:2442-52. PubMed
  • Maeno Y,Shinzato M,Nagashima S,Rittling SR,Denhardt DT,Uede T,Taniguchi K. Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus. Viral Immunol 2009; 22:139-44. PubMed
  • Leen LL,Filipe C,Billon A,Garmy-Susini B,Jalvy S,Robbesyn F,Daret D,Allieres C,Rittling SR,Werner N,Nickenig G,Deutsch U,Duplaa C,Dufourcq P,Lenfant F,Desgranges C,Arnal JF,Gadeau AP. Estrogen-stimulated endothelial repair requires osteopontin. Arterioscler Thromb Vasc Biol 2008; 28:2131-6. PubMed
  • Ono N,Nakashima K,Rittling SR,Schipani E,Hayata T,Soma K,Denhardt DT,Kronenberg HM,Ezura Y,Noda M. Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts. J Biol Chem 2008; 283:19400-9. PubMed
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