Photo of Susan R. Rittling,  PhD

Susan R. Rittling, PhD

The Forsyth Institute

The Forsyth Institute
Phone: (617) 892-8450
Fax: (617) 892-8303


srittling@forsyth.org

Susan R. Rittling, PhD

The Forsyth Institute

EDUCATIONAL TITLES

  • Instructor, Developmental Biology, Harvard School Of Dental Medicine
  • Associate Member of the Staff, Cytokine Biology, The Forsyth Institute

DF/HCC PROGRAM AFFILIATION

Research Abstract

The major focus in my lab is the origin and development of mammary cancer in the mouse. To explore the early development of these cancers, we are analyzing the stem cell origin of carcinogen-induced mammary tumors, and the role of progesterone in enhancing tumorigenesis. We are also very interested in the process of metastasis of these cancers and have developed a series of transformed cell lines that form bone metastases in syngeneic mice. The two-way mechanisms of tumor- host interaction in these metastases is an area of major focus, especially in the bone microenvironment. Finally, we have a long-standing interest in the molecular mechanisms of osteopontin function, particularly in metastasis and bone resorption.

Publications

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  • Hui T, Sørensen ES, Rittling SR. Osteopontin binding to the alpha 4 integrin requires highest affinity integrin conformation, but is independent of post-translational modifications of osteopontin. Matrix Biol 2015; 41:19-25. PubMed
  • Diao H, Liu X, Wu Z, Kang L, Cui G, Morimoto J, Denhardt DT, Rittling S, Iwakura Y, Uede T, Li L. Osteopontin regulates interleukin-17 production in hepatitis. Cytokine 2012; 60:129-37. PubMed
  • Zhang ZX, Shek K, Wang S, Huang X, Lau A, Yin Z, Sun H, Liu W, Garcia B, Rittling S, Jevnikar AM. Osteopontin expressed in tubular epithelial cells regulates NK cell-mediated kidney ischemia reperfusion injury. J Immunol 2010; 185:967-73. PubMed
  • Shimizu S, Okuda N, Kato N, Rittling SR, Shinomiya K, Muneta T, Denhardt DT, Noda M, Tsuji K, Asou Y. Osteopontin-deficiency impairs wear debris-induced osteolysis via the regulation of cytokine secretion from macrophage. Arthritis Rheum 2010; 62:1329-37. PubMed
  • Fujita N, Fujita S, Okada Y, Fujita K, Kitano A, Yamanaka O, Miyamoto T, Kon S, Uede T, Rittling SR, Denhardt DT, Saika S. Impaired angiogenic response in the corneas of mice lacking osteopontin. Invest Ophthalmol Vis Sci 2010; 51:790-4. PubMed
  • Rittling SR, Zetterberg C, Yagiz K, Skinner S, Suzuki N, Fujimura A, Sasaki H. Protective role of osteopontin in endodontic infection. Immunology 2009; 129:105-14. PubMed
  • Kurokawa M, Konno S, Takahashi A, Plunkett B, Rittling SR, Matsui Y, Kon S, Morimoto J, Uede T, Matsukura S, Kokubu F, Adachi M, Nishimura M, Huang SK. Regulatory role of DC-derived osteopontin in systemic allergen sensitization. Eur J Immunol 2009; 39:3323-30. PubMed
  • Kwok S, Rittling SR, Partridge NC, Benson CS, Thiyagaraj M, Srinivasan N, Selvamurugan N. Transforming growth factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells. J Cell Biochem 2009; 108:408-14. PubMed
  • Yagiz K,Rittling SR. Both cell-surface and secreted CSF-1 expressed by tumor cells metastatic to bone can contribute to osteoclast activation. Exp Cell Res 2009; 315:2442-52. PubMed
  • Maeno Y,Shinzato M,Nagashima S,Rittling SR,Denhardt DT,Uede T,Taniguchi K. Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus. Viral Immunol 2009; 22:139-44. PubMed
  • Leen LL,Filipe C,Billon A,Garmy-Susini B,Jalvy S,Robbesyn F,Daret D,Allieres C,Rittling SR,Werner N,Nickenig G,Deutsch U,Duplaa C,Dufourcq P,Lenfant F,Desgranges C,Arnal JF,Gadeau AP. Estrogen-stimulated endothelial repair requires osteopontin. Arterioscler Thromb Vasc Biol 2008; 28:2131-6. PubMed
  • Ono N,Nakashima K,Rittling SR,Schipani E,Hayata T,Soma K,Denhardt DT,Kronenberg HM,Ezura Y,Noda M. Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts. J Biol Chem 2008; 283:19400-9. PubMed
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