Susumu Kobayashi, MD, PhD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center


skobayas@bidmc.harvard.edu

Susumu Kobayashi, MD, PhD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Research Associate, Hematology/Oncology, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Publications

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  • Radomska HS, Jernigan F, Nakayama S, Jorge SE, Sun L, Tenen DG, Kobayashi SS. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen 2015. PubMed
  • Le X, Freed JA, VanderLaan PA, Huberman MS, Rangachari D, Jorge SE, Lucena-Araujo AR, Kobayashi SS, Balasubramanian S, He J, Chudnovksy Y, Miller VA, Ali SM, Costa DB. Detection of Crizotinib-Sensitive Lung Adenocarcinomas With MET, ALK, and ROS1 Genomic Alterations via Comprehensive Genomic Profiling. Clin Lung Cancer 2015. PubMed
  • Cai Y, Hirata A, Nakayama S, VanderLaan PA, Levantini E, Yamamoto M, Hirai H, Wong KK, Costa DB, Watanabe H, Kobayashi SS. CCAAT/Enhancer Binding Protein 硫 Is Dispensable for Development of Lung Adenocarcinoma. PLoS ONE 2015; 10:e0120647. PubMed
  • Nakayama S, Sng N, Carretero J, Welner R, Hayashi Y, Yamamoto M, Tan AJ, Yamaguchi N, Yasuda H, Li D, Soejima K, Soo RA, Costa DB, Wong KK, Kobayashi SS. 硫-Catenin Contributes to Lung Tumor Development Induced by EGFR Mutations. Cancer Res 2014; 74:5891-902. PubMed
  • de Figueiredo-Pontes LL, Wong DW, Tin VP, Chung LP, Yasuda H, Yamaguchi N, Nakayama S, Jänne PA, Wong MP, Kobayashi SS, Costa DB. Identification and characterization of ALK kinase splicing isoforms in non-small-cell lung cancer. J Thorac Oncol 2014; 9:248-53. PubMed
  • Yamaguchi N, Lucena-Araujo AR, Nakayama S, de Figueiredo-Pontes LL, Gonzalez DA, Yasuda H, Kobayashi S, Costa DB. Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer. Lung Cancer 2014; 83:37-43. PubMed
  • Yasuda H, Park E, Yun CH, Sng NJ, Lucena-Araujo AR, Yeo WL, Huberman MS, Cohen DW, Nakayama S, Ishioka K, Yamaguchi N, Hanna M, Oxnard GR, Lathan CS, Moran T, Sequist LV, Chaft JE, Riely GJ, Arcila ME, Soo RA, Meyerson M, Eck MJ, Kobayashi SS, Costa DB. Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer. Sci Transl Med 2013; 5:216ra177. PubMed
  • Kobayashi S, Canepa HM, Bailey AS, Nakayama S, Yamaguchi N, Goldstein MA, Huberman MS, Costa DB. Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors. J Thorac Oncol 2012; 8:45-51. PubMed
  • Ackerman A, Goldstein MA, Kobayashi S, Costa DB. EGFR delE709_T710insD: a rare but potentially EGFR inhibitor responsive mutation in non-small-cell lung cancer. J Thorac Oncol 2012; 7:e19-20. PubMed
  • Yasuda H, de Figueiredo-Pontes LL, Kobayashi S, Costa DB. Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer. J Thorac Oncol 2012; 7:1086-90. PubMed
  • Costa DB, Kobayashi S, Pandya SS, Yeo WL, Shen Z, Tan W, Wilner KD. CSF Concentration of the Anaplastic Lymphoma Kinase Inhibitor Crizotinib. J Clin Oncol 2011. PubMed
  • Li-Wan-Po A, Farndon PA, Kobayashi S, Mitsudomi T, Potter VA. The Pharmacogenetic Rescue of Side-Lined Anticancer Drugs to the Front-Line: Gefitinib as a Case Example (February). 2011. PubMed
  • Usuba T, Misawa T, Toyama Y, Ishida Y, Ishii Y, Yanagisawa S, Kobayashi S, Yanaga K. Is modified Devine exclusion necessary for gastrojejunostomy in patients with unresectable pancreatobiliary cancer? Surg Today 2010; 41:97-100. PubMed
  • Akashi S, Kimura T, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T. Neoechinulin a impedes the progression of rotenone-induced cytotoxicity in PC12 cells. Biol Pharm Bull 2011; 34:243-8. PubMed
  • Zhang Z, Stiegler AL, Boggon TJ, Kobayashi S, Halmos B. EGFR-mutated lung cancer: a paradigm of molecular oncology. 2011; 1:497-514. PubMed
  • Costa DB, Kobayashi S, Yeo WL, Hamada A. Serum concentrations of Erlotinib at a dose of 25 mg daily. J Thorac Oncol 2010; 5:1311-2. PubMed
  • Akiba T, Marushima H, Kawahara H, Takagi M, Hirano J, Odaka M, Nakanishi K, Takeyama H, Kobayashi S, Morikawa T. Video-assisted thoracic surgery for patients with lung cancer and interstitial pneumonia. Ann Thorac Cardiovasc Surg 2010; 16:236-41. PubMed
  • Akiba T, Marushima H, Hiramatsu M, Matsudaira H, Nakanishi K, Takeyama H, Kobayashi S, Morikawa T. Video-assisted thoracoscopic surgery for non-small cell lung cancer in patients on hemodialysis. Ann Thorac Cardiovasc Surg 2010; 16:40-4. PubMed
  • O'Brien KB, Alberich-Jordà M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development 2010; 137:2147-56. PubMed
  • Yeo WL, Riely GJ, Yeap BY, Lau MW, Warner JL, Bodio K, Huberman MS, Kris MG, Tenen DG, Pao W, Kobayashi S, Costa DB. Erlotinib at a dose of 25 mg daily for non-small cell lung cancers with EGFR mutations. J Thorac Oncol 2010; 5:1048-53. PubMed
  • Akiba T, Marushima H, Odaka M, Harada J, Kobayashi S, Morikawa T. Pulmonary vein analysis using three-dimensional computed tomography angiography for thoracic surgery. Gen Thorac Cardiovasc Surg 2010; 58:331-5. PubMed
  • Will B, Siddiqi T, Alberich Jordà M, Shimamura T, Luptakova K, Staber PB, Costa DB, Steidl U, Tenen DG, Kobayashi S. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood 2010; 115:2901-9. PubMed
  • Zhang Z, Kobayashi S, Borczuk AC, Leidner RS, Laframboise T, Levine AD, Halmos B. Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK-signaling in lung cancer cells. Carcinogenesis 2010; 31:577-86. PubMed
  • Kinoshita S,Hirano A,Kobayashi S,Komine K,Kyoda S,Takeyama H,Uchida K,Morikawa T,Nagase J,Sakamoto G. Metachronous secondary primary occult breast cancer initially presenting with metastases to the contralateral axillary lymph nodes: report of a case. Breast Cancer 2009; 17:71-4. PubMed
  • Kawahara H, Watanabe K, Ushigome T, Noaki R, Kobayashi S, Yanaga K. Retrograde single stapling technique for laparoscopic ultralow anterior resection. 2010; 27:261-4. PubMed
  • Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, Solomon B, Stubbs H, Admane S, McDermott U, Settleman J, Kobayashi S, Mark EJ, Rodig SJ, Chirieac LR, Kwak EL, Lynch TJ, Iafrate AJ. Clinical Features and Outcome of Patients With Non-Small-Cell Lung Cancer Who Harbor EML4-ALK. J Clin Oncol 2009; 27:4247-53. PubMed
  • Nguyen KS, Kobayashi S, Costa DB. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Clin Lung Cancer 2009; 10:281-9. PubMed
  • Naumov GN,Nilsson MB,Cascone T,Briggs A,Straume O,Akslen LA,Lifshits E,Byers LA,Xu L,Wu HK,Janne P,Kobayashi S,Halmos B,Tenen D,Tang XM,Engelman J,Yeap B,Folkman J,Johnson BE,Heymach JV. Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance. Clin Cancer Res 2009; 15:3484-94. PubMed
  • Akiba T,Marushima H,Masubuchi M,Kobayashi S,Morikawa T. Small symptomatic pericardial diverticula treated by video-assisted thoracic surgical resection. Ann Thorac Cardiovasc Surg 2009; 15:123-5. PubMed
  • Costa DB,Kobayashi S. Gefitinib plus docetaxel in non-small-cell lung cancer. Lancet 2009; 373:541; author reply 542. PubMed
  • Akiba T, Marushima H, Harada J, Kobayashi S, Morikawa T. Importance of preoperative imaging with 64-row three-dimensional multidetector computed tomography for safer video-assisted thoracic surgery in lung cancer. Surg Today 2009; 39:844-7. PubMed
  • Akiba T,Ishiyama M,Marushima H,Nojima K,Kobayashi S,Morikawa T. Temporary claviculectomy approach for plexiform neurofibroma of the first intercostal nerve. Surg Today 2009; 39:544-7. PubMed
  • Kitajima K,Kobayashi S,Shiba H,Uwagawa T,Ishida Y,Aiba K,Kawakami M,Yanaga K. Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene. Int J Clin Oncol 2008; 13:545-51. PubMed
  • Costa DB,Nguyen KS,Cho BC,Sequist LV,Jackman DM,Riely GJ,Yeap BY,Halmos B,Kim JH,Janne PA,Huberman MS,Pao W,Tenen DG,Kobayashi S. Effects of erlotinib in EGFR mutated non-small cell lung cancers with resistance to gefitinib. Clin Cancer Res 2008; 14:7060-7. PubMed
  • Kobayashi T,Kawahara H,Koido S,Kobayashi S,Kashiwagi H,Yanaga K. Significance of thymidine phosphorylase expression in stromal cells around invasive front of rectal cancer. Hepatogastroenterology 2009; 55:2045-8. PubMed
  • Akiba T,Marushima H,Harada J,Kobayashi S,Morikawa T. Anomalous pulmonary vein detected using three-dimensional computed tomography in a patient with lung cancer undergoing thoracoscopic lobectomy. Gen Thorac Cardiovasc Surg 2008; 56:413-6. PubMed
  • Shimamura T,Li D,Ji H,Haringsma HJ,Liniker E,Borgman CL,Lowell AM,Minami Y,McNamara K,Perera SA,Zaghlul S,Thomas RK,Greulich H,Kobayashi S,Chirieac LR,Padera RF,Kubo S,Takahashi M,Tenen DG,Meyerson M,Wong KK,Shapiro GI. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res 2008; 68:5827-38. PubMed
  • Saitoh T, Kuramochi K, Imai T, Takata KI, Takehara M, Kobayashi S, Sakaguchi K, Sugawara F. Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro. Bioorg Med Chem 2008; 16:5815-25. PubMed
  • Kuramochi K, Yukizawa S, Ikeda S, Sunoki T, Arai S, Matsui R, Morita A, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S. Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation. Bioorg Med Chem 2008; 16:5039-49. PubMed
  • Costa DB, Schumer ST, Tenen DG, Kobayashi S. Differential responses to erlotinib in epidermal growth factor receptor (EGFR)-mutated lung cancers with acquired resistance to gefitinib carrying the L747S or T790M secondary mutations. J Clin Oncol 2008; 26:1182-4; author reply 1184-6. PubMed
  • Kobayashi S, Hara M, Yano M, Tateyama H, Shibamoto Y. Dendriform pulmonary ossification in a patient with a past history of giant cell tumor in femur. J Thorac Imaging 2008; 23:47-9. PubMed
  • Costa DB, Kobayashi S. Response of intracranial metastases to epidermal growth factor receptor tyrosine kinase inhibitors: it may all depend on EGFR mutations. J Clin Oncol 2008; 26:686. PubMed
  • Akiba T,Marushima H,Takagi M,Odaka M,Harada J,Kobayashi S,Morikawa T. Preoperative evaluation of a tracheal bronchus by three-dimensional 64-row multidetector-row computed tomography (MDCT) bronchography and angiography: report of a case. Surg Today 2008; 38:841-3. PubMed
  • Kinoshita S,Hirano A,Komine K,Kobayashi S,Kyoda S,Takeyama H,Uchida K,Morikawa T,Nagase J,Sakamoto G. Primary small-cell neuroendocrine carcinoma of the breast: report of a case. Surg Today 2008; 38:734-8. PubMed
  • Costa DB, Kobayashi S, Schumer ST. Erlotinib-associated alopecia in a lung cancer patient. J Thorac Oncol 2007; 2:1136-8. PubMed
  • Aoki S, Morohashi K, Sunoki T, Kuramochi K, Kobayashi S, Sugawara F. Screening of paclitaxel-binding molecules from a library of random peptides displayed on T7 phage particles using paclitaxel-photoimmobilized resin. Bioconjug Chem 2007; 18:1981-6. PubMed
  • Yu Z, Boggon TJ, Kobayashi S, Jin C, Ma PC, Dowlati A, Kern JA, Tenen DG, Halmos B. Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies. Cancer Res 2007; 67:10417-27. PubMed
  • Koido S, Hara E, Homma S, Mitsunaga M, Takahara A, Nagasaki E, Kawahara H, Watanabe M, Toyama Y, Yanagisawa S, Kobayashi S, Yanaga K, Fujise K, Gong J, Tajiri H. Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells. J Immunol 2007; 179:4874-83. PubMed
  • Costa DB, Kobayashi S, Tenen DG, Huberman MS. Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers. Lung Cancer 2007; 58:95-103. PubMed
  • Costa DB, Halmos B, Kumar A, Schumer ST, Huberman MS, Boggon TJ, Tenen DG, Kobayashi S. BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med 2007; 4:1669-79; discussion 1680. PubMed
  • Steidl U, Steidl C, Ebralidze A, Chapuy B, Han HJ, Will B, Rosenbauer F, Becker A, Wagner K, Koschmieder S, Kobayashi S, Costa DB, Schulz T, O'Brien KB, Verhaak RG, Delwel R, Haase D, Trumper L, Krauter J, Kohwi-Shigematsu T, Griesinger F, Tenen DG. A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia. J Clin Invest 2007; 117:2611-20. PubMed
  • Kobayashi S, Shimamura T, Monti S, Steidl U, Hetherington CJ, Lowell AM, Golub T, Meyerson M, Tenen DG, Shapiro GI, Halmos B. Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling. Cancer Res 2006; 66:11389-98. PubMed
  • Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, J. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell 2006; 9:485-95. PubMed
  • Kobayashi S, Ji H, Yuza Y, Meyerson M, Wong KK, Tenen DG, Halmos B. An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor. Cancer Res 2005; 65:7096-101. PubMed
  • Kobayashi S, Boggon TJ, Dayaram T, J. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005; 352:786-92. PubMed
  • Ushigome T, Kawahara H, Kobayashi T, Kobayashi S, Kashiwagi H, Yanaga K. Where should the specimen be excised for the chemosensitivity of colorectal cancer to 5-fluorouracil? Hepatogastroenterology 2011; 57:1090-4. PubMed
  • Kawahara H, Kobayashi T, Watanabe K, Kobayashi S, Kashiwagi H, Yanaga K. Where is the best surgical incision for laparoscopic anterior resection? Hepatogastroenterology 2010; 56:1629-32. PubMed
  • Kawahara H, Watanabe K, Ushigome T, Noaki R, Kobayashi S, Yanaga K. Laparoscopy-assisted lateral pelvic lymph node dissection for advanced rectal cancer. Hepatogastroenterology 2011; 57:1136-8. PubMed
  • Noaki R, Kawahara H, Watanabe K, Ushigome T, Kobayashi S, Yanaga K. Serum p53 antibody is a useful tumor marker of early colorectal cancer. Int Surg 2011; 95:287-92. PubMed
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