Photo of Tayyaba Hasan,  PhD

Tayyaba Hasan, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-6996
Fax: (617) 724-1345


thasan@partners.org

Tayyaba Hasan, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Dermatology, Harvard Medical School
  • Professor, Health Sciences and Technology, Harvard Medical School
  • Biochemist, Wellman Center for Photomedicine, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Activation of certain chemicals with light leads to photochemical processes that involve the generation of free radicals and excited oxygen species. These molecular species are capable of destroying cells and tissues at or near the areas of photochemistry initiation. An advantage of this approach is that it provides the potential of double selectivity; first, due to the confinement of sites of illumination, and second, due to preferential localization of the activatable chemicals in many neoplastic tissues. Selectivity is further enhanced by delivering the photoactivatable molecules via vehicles such as antibodies and liposomes. The mechanisms of tissue destruction by photochemical processes are different from those used by most cheomtherapeutic drugs. This provides the possibility of using targeted photocemistry in combination with conventional chemotherapy to: 1) destroy cells that are resistant (acquired or intrinsic), and 2) achieve better (broader) tumor response due to the more varied arsenal for attack provided by the combination of photochemical and chemotherapeutic approaches. The best known biomedical application of photochemical targeting is photodynamic therapy (PDT). Research in our laboratories is focused on the mechanistic, therapeutic, and imaging aspects of photobiology to cancer.

Publications

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  • Spring BQ, Rizvi I, Xu N, Hasan T. The role of photodynamic therapy in overcoming cancer drug resistance. Photochem Photobiol Sci 2015. PubMed
  • Elliott JT, Samkoe KS, Gunn JR, Stewart EE, Gardner TB, Tichauer KM, Lee TY, Hoopes PJ, Pereira SP, Hasan T, Pogue BW. Perfusion CT Estimates Photosensitizer Uptake and Biodistribution in a Rabbit Orthotopic Pancreatic Cancer Model: A Pilot Study. Acad Radiol 2015. PubMed
  • Mallidi S, Watanabe K, Timerman D, Schoenfeld D, Hasan T. Prediction of tumor recurrence and therapy monitoring using ultrasound-guided photoacoustic imaging. Theranostics 2015; 5:289-301. PubMed
  • Spring BQ, Palanisami A, Hasan T. Microscale receiver operating characteristic analysis of micrometastasis recognition using activatable fluorescent probes indicates leukocyte imaging as a critical factor to enhance accuracy. J Biomed Opt 2014; 19:66006. PubMed
  • Anand S, Rollakanti KR, Horst RL, Hasan T, Maytin EV. Combination of Oral Vitamin D3 with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma. Photochem Photobiol 2014. PubMed
  • Jermyn M, Davis SC, Dehghani H, Huggett MT, Hasan T, Pereira SP, Bown SG, Pogue BW. CT contrast predicts pancreatic cancer treatment response to verteporfin-based photodynamic therapy. Phys Med Biol 2014; 59:1911-21. PubMed
  • Ghogare AA, Rizvi I, Hasan T, Greer A. "Pointsource" Delivery of a Photosensitizer Drug and Singlet Oxygen: Eradication of Glioma Cells In Vitro. Photochem Photobiol 2014. PubMed
  • Spring BQ, Abu-Yousif AO, Palanisami A, Rizvi I, Zheng X, Mai Z, Anbil S, Sears RB, Mensah LB, Goldschmidt R, Erdem SS, Oliva E, Hasan T. Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates. Proc Natl Acad Sci U S A 2014; 111:E933-42. PubMed
  • Mallidi S, Anbil S, Lee S, Manstein D, Elrington S, Kositratna G, Schoenfeld D, Pogue B, Davis SJ, Hasan T. Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy nduced clinical erythema. J Biomed Opt 2014; 19:028001. PubMed
  • Celli JP, Rizvi I, Blanden AR, Massodi I, Glidden MD, Pogue BW, Hasan T. An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models. Sci Rep 2014; 4:3751. PubMed
  • Samkoe KS, Bryant A, Gunn JR, Pereira SP, Hasan T, Pogue BW. Contrast enhanced-magnetic resonance imaging as a surrogate to map verteporfin delivery in photodynamic therapy. J Biomed Opt 2013; 18:120504. PubMed
  • Tichauer KM, Deharvengt SJ, Samkoe KS, Gunn JR, Bosenberg MW, Turk MJ, Hasan T, Stan RV, Pogue BW. Tumor Endothelial Marker Imaging in Melanomas Using Dual-Tracer Fluorescence Molecular Imaging. Mol Imaging Biol 2013. PubMed
  • Anbil S, Rizvi I, Celli JP, Alagic N, Pogue BW, Hasan T. Impact of treatment response metrics on photodynamic therapy planning and outcomes in a three-dimensional model of ovarian cancer. J Biomed Opt 2014; 18:98004. PubMed
  • Anand S, Hasan T, Maytin EV. Mechanism of differentiation-enhanced photodynamic therapy for cancer: upregulation of coproporphyrinogen oxidase by C/EBP transcription factors. Mol Cancer Ther 2013; 12:1638-50. PubMed
  • Davis SC, Samkoe KS, Tichauer KM, Sexton KJ, Gunn JR, Deharvengt SJ, Hasan T, Pogue BW. Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo. Proc Natl Acad Sci U S A 2013. PubMed
  • Rizvi I, Gurkan UA, Tasoglu S, Alagic N, Celli JP, Mensah LB, Mai Z, Demirci U, Hasan T. Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules. Proc Natl Acad Sci U S A 2013. PubMed
  • Bartusik D, Aebisher D, Ghogare A, Ghosh G, Abramova I, Hasan T, Greer A. A Fiberoptic (Photodynamic Therapy Type) Device with a Photosensitizer and Singlet Oxygen Delivery Probe Tip for Ovarian Cancer Cell Killing. Photochem Photobiol 2013. PubMed
  • Rizvi I, Anbil S, Alagic N, Celli JP, Zheng LZ, Palanisami A, Glidden MD, Pogue BW, Hasan T. PDT Dose Parameters Impact Tumoricidal Durability and Cell Death Pathways in a 3D Ovarian Cancer Model. Photochem Photobiol 2013. PubMed
  • Mir Y, Elrington SA, Hasan T. A new nanoconstruct for epidermal growth factor receptor-targeted photo-immunotherapy of ovarian cancer. 2013. PubMed
  • Anand S, Ortel BJ, Pereira SP, Hasan T, Maytin EV. Biomodulatory approaches to photodynamic therapy for solid tumors. Cancer Lett 2012; 326:8-16. PubMed
  • Kimani S, Ghosh G, Ghogare A, Rudshteyn B, Bartusik D, Hasan T, Greer A. Synthesis and Characterization of Mono-, Di-, and Tri-Poly(ethylene glycol) Chlorin e(6) Conjugates for the Photokilling of Human Ovarian Cancer Cells. J Org Chem 2012. PubMed
  • Hasan T. Using cellular mechanisms to develop effective combinations of photodynamic therapy and targeted therapies. J Natl Compr Canc Netw 2012; 10 Suppl 2:S23-6. PubMed
  • Rizvi I, Dinh TA, Yu W, Chang Y, Sherwood ME, Hasan T. Photoimmunotherapy and irradiance modulation reduce chemotherapy cycles and toxicity in a murine model for ovarian carcinomatosis: perspective and results. Isr. J. Chem. 2013; 52:776-787. PubMed
  • Dhar DK, Damink SW, Brindley JH, Godfrey A, Chapman MH, Sandanayake NS, Andreola F, Mazurek S, Hasan T, Malago M, Pereira SP. Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer. Cancer 2012. PubMed
  • Torosean S, Flynn B, Axelsson J, Gunn J, Samkoe KS, Hasan T, Doyley MM, Pogue BW. Nanoparticle uptake in tumors is mediated by the interplay of vascular and collagen density with interstitial pressure. 2012. PubMed
  • Tichauer KM, Samkoe KS, Sexton KJ, Gunn JR, Hasan T, Pogue BW. Improved tumor contrast achieved by single time point dual-reporter fluorescence imaging. J Biomed Opt 2012; 17:066001. PubMed
  • Abu-Yousif AO, Moor AC, Zheng X, Savellano MD, Yu W, Selbo PK, Hasan T. Epidermal growth factor receptor-targeted photosensitizer selectively inhibits EGFR signaling and induces targeted phototoxicity in ovarian cancer cells. Cancer Lett 2012. PubMed
  • Glidden MD, Celli JP, Massodi I, Rizvi I, Pogue BW, Hasan T. Image-Based Quantification of Benzoporphyrin Derivative Uptake, Localization, and Photobleaching in 3D Tumor Models, for Optimization of PDT Parameters. Theranostics 2012; 2:827-39. PubMed
  • Xu F, Celli J, Rizvi I, Moon S, Hasan T, Demirci U. A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform. Biotechnol J 2011; 6:204-12. PubMed
  • Rahmanzadeh R, Rai P, Celli JP, Rizvi I, Baron-Lühr B, Gerdes J, Hasan T. Ki-67 as a molecular target for therapy in an in vitro three-dimensional model for ovarian cancer. Cancer Res 2010; 70:9234-42. PubMed
  • Rizvi I, Celli JP, Evans CL, Abu-Yousif AO, Muzikansky A, Pogue BW, Finkelstein D, Hasan T. Synergistic enhancement of carboplatin efficacy with photodynamic therapy in a three-dimensional model for micrometastatic ovarian cancer. Cancer Res 2010; 70:9319-28. PubMed
  • Rai P, Mallidi S, Zheng X, Rahmanzadeh R, Mir Y, Elrington S, Khurshid A, Hasan T. Development and applications of photo-triggered theranostic agents. Adv Drug Deliv Rev 2010; 62:1094-124. PubMed
  • Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe KS, Verma S, Pogue BW, Hasan T. Imaging and photodynamic therapy: mechanisms, monitoring, and optimization. Chem. Rev. 2010; 110:2795-838. PubMed
  • Joo C, Evans CL, Stepinac T, Hasan T, de Boer JF. Diffusive and directional intracellular dynamics measured by field-based dynamic light scattering. Opt Express 2010; 18:2858-71. PubMed
  • Gibbs-Strauss SL, Samkoe KS, O'Hara JA, Davis SC, Hoopes PJ, Hasan T, Pogue BW. Detecting epidermal growth factor receptor tumor activity in vivo during cetuximab therapy of murine gliomas. Acad Radiol 2009; 17:7-17. PubMed
  • Samkoe KS, Chen A, Rizvi I, O'Hara JA, Hoopes PJ, Pereira SP, Hasan T, Pogue BW. Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft models. Int J Radiat Oncol Biol Phys 2009; 76:251-9. PubMed
  • Evans CL,Rizvi I,Hasan T,de Boer JF. In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging. Opt Express 2009; 17:8892-906. PubMed
  • Abu-Yousif AO, Rizvi I, Evans CL, Celli JP, Hasan T. PuraMatrix encapsulation of cancer cells. 2009. PubMed
  • Akilov OE, Kosaka S, Maytin EV, Hasan T. Prospects for the use of differentiation-modulating agents as adjuvant of photodynamic therapy for proliferative dermatoses. J Dermatol 2008; 35:197-205. PubMed
  • Styer AK, Sullivan BT, Puder M, Arsenault D, Petrozza JC, Serikawa T, Chang S, Hasan T, Gonzalez RR, Rueda BR. Ablation of leptin signaling disrupts the establishment, development, and maintenance of endometriosis-like lesions in a murine model. Endocrinology 2007; 149:506-14. PubMed
  • Akilov OE, Donovan MJ, Stepinac T, Carter CR, Whitcomb JP, Hasan T, McDowell MA. T helper type 1 cytokines and keratinocyte growth factor play a critical role in pseudoepitheliomatous hyperplasia initiation during cutaneous leishmaniasis. Arch Dermatol Res 2007; 299:315-25. PubMed
  • Zhou X, Chen B, Hoopes PJ, Hasan T, Pogue BW. Tumor vascular area correlates with photosensitizer uptake: analysis of verteporfin microvascular delivery in the dunning rat prostate tumor. Photochem Photobiol 2007; 82:1348-57. PubMed
  • Sinha AK, Anand S, Ortel BJ, Chang Y, Mai Z, Hasan T, Maytin EV. Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells. Br J Cancer 2006; 95:485-95. PubMed
  • Casas A, Perotti C, Ortel B, Di Venosa G, Saccoliti M, Batlle A, Hasan T. Tumor cell lines resistant to ALA-mediated photodynamic therapy and possible tools to target surviving cells. Int J Oncol 2006; 29:397-405. PubMed
  • Solban N, Selbo PK, P. Mechanistic investigation and implications of photodynamic therapy induction of vascular endothelial growth factor in prostate cancer. Cancer Res 2006; 66:5633-40. PubMed
  • Zhou X, Pogue BW, Chen B, Demidenko E, Joshi R, Hoopes J, Hasan T. Pretreatment photosensitizer dosimetry reduces variation in tumor response. Int J Radiat Oncol Biol Phys 2006; 64:1211-20. PubMed
  • del Carmen MG, Rizvi I, Chang Y, Moor AC, Oliva E, Sherwood M, Pogue B, Hasan T. Synergism of epidermal growth factor receptor-targeted immunotherapy with photodynamic treatment of ovarian cancer in vivo. J Natl Cancer Inst 2005; 97:1516-24. PubMed
  • Savellano MD, Hasan T. Photochemical targeting of epidermal growth factor receptor: a mechanistic study. Clin Cancer Res 2005; 11:1658-68. PubMed
  • Chen B, Pogue BW, Zhou X, O'Hara JA, Solban N, Demidenko E, Hoopes PJ, Hasan T. Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model. Clin Cancer Res 2005; 11:720-7. PubMed
  • Duska LR, Wimberly J, Deutsch TF, Ortel B, Haas J, Houck K, Hasan T. Detection of female lower genital tract dysplasia using orally administered 5-aminolevulinic acid induced protoporphyrin IX: a preliminary study. Gynecol Oncol 2002; 85:125-8. PubMed
  • Pogue BW, Samkoe KS, Hextrum S, O'Hara JA, Jermyn M, Srinivasan S, Hasan T. Imaging targeted-agent binding in vivo with two probes. J Biomed Opt 2010; 15:030513. PubMed
  • Celli JP, Rizvi I, Evans CL, Abu-Yousif AO, Hasan T. Quantitative imaging reveals heterogeneous growth dynamics and treatment-dependent residual tumor distributions in a three-dimensional ovarian cancer model. J Biomed Opt 2010; 15:051603. PubMed
  • Tichauer KM, Samkoe KS, Gunn JR, Kanick SC, Hoopes PJ, Barth RJ, Kaufman PA, Hasan T, Pogue BW. Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging Nat Med 2014.
  • Gruber JD, Paliwal A, Krishnaswamy V, Ghadyani H, Jermyn M, O'Hara JA, Davis SC, Kerley-Hamilton JS, Shworak NW, Maytin EV, Hasan T, Pogue BW. System development for high frequency ultrasound-guided fluorescence quantification of skin layers. J Biomed Opt 2010; 15:026028. PubMed
  • Molpus KL, Kato D, Hamblin MR, Lilge L, Bamberg M, Hasan T. Intraperitoneal photodynamic therapy of human epithelial ovarian carcinomatosis in a xenograft murine model. Cancer Res 1996; 56:1075-82. PubMed
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