Terry B. Strom, MD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 632-0150
Fax: (617) 732-0160


tstrom@caregroup.harvard.edu

Terry B. Strom, MD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Professor, Surgery, Harvard Medical School
  • Director, Immunology, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

We are interested in the precise molecular mechanisms that drive lymphocyte activation, proliferation and apoptosis. The context of our studies is the acquisition and maintenance of immune tolerance to transplant and autoantigens. We have initiated studies that attempt to "break tolerance" to autologous cancers in an effort to develop immune based anti-tumor therapies.

Publications

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  • Otterbein LE, Fan Z, Koulmanda M, Thronley T, Strom TB. Innate immunity for better or worse govern the allograft response. Curr Opin Organ Transplant 2015; 20:8-12. PubMed
  • Koulmanda M, Pomahac B, Fan Z, Murphy GF, Strom TB. Hand transplants and the mandate for tolerance. Curr Opin Organ Transplant 2014; 19:545-51. PubMed
  • Fischer S, Lian CG, Kueckelhaus M, Strom TB, Edelman ER, Clark RA, Murphy GF, Chandraker AK, Riella LV, Tullius SG, Pomahac B. Acute rejection in vascularized composite allotransplantation. Curr Opin Organ Transplant 2014. PubMed
  • Thornley TB, Fang Z, Balasubramanian S, Larocca RA, Gong W, Gupta S, Csizmadia E, Degauque N, Kim BS, Koulmanda M, Kuchroo VK, Strom TB. Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory. J Clin Invest 2014; 124:3443-54. PubMed
  • Yang X, Kallarakal A, Saptharishi N, Jiang H, Yang Z, Xie Y, Mitra G, Zheng XX, Strom TB, Soman G. Molecular characterization and functional activity of an IL-15 antagonist MutIL-15/Fc human fusion protein. Mol Pharm 2013; 10:717-27. PubMed
  • Carlson AL, Fujisaki J, Wu J, Runnels JM, Turcotte R, Celso CL, Scadden DT, Strom TB, Lin CP. Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label. PLoS ONE 2013; 8:e69257. PubMed
  • Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB. TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77. Sci Signal 2012; 5:ra90. PubMed
  • Koulmanda M, Bhasin M, Fan Z, Hanidziar D, Goel N, Putheti P, Movahedi B, Libermann TA, Strom TB. Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci U S A 2012; 109:15443-8. PubMed
  • Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR. Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood 2012; 120:682-90. PubMed
  • Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest 2012; 122:2395-404. PubMed
  • El Essawy B, Putheti P, Gao W, Strom TB. Rapamycin Generates Graft-Homing Murine Suppressor CD8(+) T Cells That Confer Donor-Specific Graft Protection. Cell Transplant 2011. PubMed
  • Park J, Gao W, Whiston R, Strom TB, Metcalfe S, Fahmy TM. Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery. Mol Pharm 2011; 8:143-52. PubMed
  • S├ínchez-Fueyo A, Strom TB. Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs. Gastroenterology 2010; 140:51-64. PubMed
  • Kirk A, Strom TB. Immunogenetics and transplantation. Curr Opin Immunol 2010; 22:631-3. PubMed
  • Fan Z, Spencer JA, Lu Y, Pitsillides CM, Singh G, Kim P, Yun SH, Toxavidis V, Strom TB, Lin CP, Koulmanda M. In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response. Nat Med 2010; 16:718-22. PubMed
  • Kang HG, Lee JE, Yang SH, Lee SH, Gao W, Strom TB, Oh K, Lee DS, Kim YS. Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens. Immunology 2010; 129:567-77. PubMed
  • Putheti P, Awasthi A, Popoola J, Gao W, Strom TB. Human CD4 memory T cells can become CD4+IL-9+ T cells. PLoS ONE 2010; 5:e8706. PubMed
  • Hanidziar D, Koulmanda M, Strom TB. Creating transplant tolerance by taming adverse intragraft innate immunity. F1000 Biol Rep 2011; 2:83. PubMed
  • Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol 2009; 39:2492-501. PubMed
  • Strom TB, Koulmanda M. Recently discovered T cell subsets cannot keep their commitments. J Am Soc Nephrol 2009; 20:1677-80. PubMed
  • Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, Beckhove P, Gounari F, Khazaie K. T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res 2009; 69:5490-7. PubMed
  • Gao W,Thompson L,Zhou Q,Putheti P,Fahmy TM,Strom TB,Metcalfe SM. Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6. Cell Cycle 2009; 8:1444-50. PubMed
  • Mariat C,Degauque N,Balasubramanian S,Kenny J,DeKruyff RH,Umetsu DT,Kuchroo V,Zheng XX,Strom TB. Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation. J Immunol 2009; 182:1379-85. PubMed
  • Dardalhon V,Awasthi A,Kwon H,Galileos G,Gao W,Sobel RA,Mitsdoerffer M,Strom TB,Elyaman W,Ho IC,Khoury S,Oukka M,Kuchroo VK. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 2008; 9:1347-55. PubMed
  • Strom TB,Koulmanda M. Cytokine related therapies for autoimmune disease. Curr Opin Immunol 2008; 20:676-81. PubMed
  • Koulmanda M,Bhasin M,Hoffman L,Fan Z,Qipo A,Shi H,Bonner-Weir S,Putheti P,Degauque N,Libermann TA,Auchincloss H Jr,Flier JS,Strom TB. Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A 2008; 105:16242-7. PubMed
  • Feng G,Gao W,Strom TB,Oukka M,Francis RS,Wood KJ,Bushell A. Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells. Eur J Immunol 2008; 38:2512-27. PubMed
  • Muthukumarana PA, Zheng XX, Rosengard BR, Strom TB, Metcalfe SM. In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFbeta, but has no immediate effect on Foxp3. Transpl Int 2008; 21:593-7. PubMed
  • Tzianabos AO,Holsti MA,Zheng XX,Stucchi AF,Kuchroo VK,Strom TB,Glimcher LH,Cruikshank WW. Functional Th1 cells are required for surgical adhesion formation in a murine model. J Immunol 2008; 180:6970-6. PubMed
  • Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol 2008; 180:4706-13. PubMed
  • Degauque N, Mariat C, Kenny J, Zhang D, Gao W, Vu MD, Alexopoulos S, Oukka M, Umetsu DT, DeKruyff RH, Kuchroo V, Zheng XX, Strom TB. Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J Clin Invest 2007; 118:735-41. PubMed
  • Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007; 448:484-7. PubMed
  • Degauque N, Mariat C, Kenny J, Sanchez-Fueyo A, Alexopoulos SP, Kuchroo V, Zheng XX, Strom TB. Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins. Transplantation 2007; 84:S12-6. PubMed
  • Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med 2007; 204:1691-702. PubMed
  • Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant 2007; 7:1722-32. PubMed
  • Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007; 204:1257-65. PubMed
  • Sanchez-Fueyo A, Domenig CM, Mariat C, Alexopoulos S, Zheng XX, Strom TB. Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantation. Transpl Int 2007; 20:534-41. PubMed
  • Koyama I, Nadazdin O, Boskovic S, Ochiai T, Smith RN, Sykes M, Sogawa H, Murakami T, Strom TB, Colvin RB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant 2007; 7:1055-61. PubMed
  • El Essawy B, Otu HH, Choy B, Zheng XX, Libermann TA, Strom TB. Proteomic analysis of the allograft response. Transplantation 2006; 82:267-74. PubMed
  • Kato K, Jeanneau C, Tarp MA, Benet-Pag. Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation. J Biol Chem 2006; 281:18370-7. PubMed
  • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235-8. PubMed
  • Koulmanda M, Smith RN, Qipo A, Weir G, Auchincloss H, Strom TB. Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure? Am J Transplant 2006; 6:687-96. PubMed
  • Diem Vu M, Li Y, Strom TB, Li XC. Mycophenolate mofetil is compatible with CD28/CD154 costimulatory blockade in preventing transplant rejection. Transplantation 2005; 79:736. PubMed
  • McDaid J, Yamashita K, Chora A, Ollinger R, Strom TB, Li XC, Bach FH, Soares MP. Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells. FASEB J 2005; 19:458-60. PubMed
  • S. Immunological tolerance and liver transplantation. J Hepatol 2004; 41:698-705. PubMed
  • Sabatos CA, Chakravarti S, Cha E, Schubart A, S. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol 2003; 4:1102-10. PubMed
  • Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Fu TM, Wagner W, Bilska M, Craiu A, Zheng XX, Krivulka GR, Beaudry K, Lifton MA, Nickerson CE, Trigona WL, Punt K, Freed DC, Guan L, Dubey S, Casimiro D, Simon A, Davies ME, Chastain M, Strom TB, Gelman RS, Montefiori DC, Lewis MG, Emini EA, Shiver JW, Letvin NL. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 2000; 290:486-92. PubMed
  • Wells AD, Li XC, Li Y, Walsh MC, Zheng XX, Wu Z, Nu. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med 1999; 5:1303-7. PubMed
  • Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999; 5:1298-302. PubMed
  • Li XC, Zand MS, Li Y, Zheng XX, Strom TB. On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses. J Immunol 1998; 161:2241-7. PubMed
  • Tran HM, Nickerson PW, Restifo AC, Ivis-Woodward MA, Patel A, Allen RD, Strom TB, O'Connell PJ. Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment. J Immunol 1997; 159:2232-9. PubMed
  • Zheng XX, Sayegh MH, Zheng XG, Li Y, Linsley PS, Peach R, Borriello F, Strom TB, Sharpe AH, Turka LA. The role of donor and recipient B7-1 (CD80) in allograft rejection. J Immunol 1997; 159:1169-73. PubMed
  • Tivol EA, Boyd SD, McKeon S, Borriello F, Nickerson P, Strom TB, Sharpe AH. CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J Immunol 1997; 158:5091-4. PubMed
  • Zheng XX, Steele AW, Hancock WW, Stevens AC, Nickerson PW, Roy-Chaudhury P, Tian Y, Strom TB. A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice. J Immunol 1997; 158:4507-13. PubMed
  • Perez VL, Van Parijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 1997; 6:411-7. PubMed
  • Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharpe AH. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 1997; 6:303-13. PubMed
  • Strehlau J, Pavlakis M, Lipman M, Shapiro M, Vasconcellos L, Harmon W, Strom TB. Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc Natl Acad Sci U S A 1997; 94:695-700. PubMed
  • Strom TB, Roy-Chaudhury P, Manfro R, Zheng XX, Nickerson PW, Wood K, Bushell A. The Th1/Th2 paradigm and the allograft response. Curr Opin Immunol 1996; 8:688-93. PubMed
  • Pavlakis M, Strehlau J, Lipman M, Shapiro M, Maslinski W, Strom TB. Intragraft IL-15 transcripts are increased in human renal allograft rejection. Transplantation 1996; 62:543-5. PubMed
  • Strehlau J, Pavlakis M, Lipman M, Maslinski W, Shapiro M, Strom TB. The intragraft gene activation of markers reflecting T-cell-activation and -cytotoxicity analyzed by quantitative RT-PCR in renal transplantation. Clin Nephrol 1996; 46:30-3. PubMed
  • Nickerson P, Zheng XX, Steiger J, Steele AW, Steurer W, Roy-Chaudhury P, M. Prolonged islet allograft acceptance in the absence of interleukin 4 expression. Transpl Immunol 1996; 4:81-5. PubMed
  • Steiger J, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom TB. IL-2 knockout recipient mice reject islet cell allografts. J Immunol 1995; 155:489-98. PubMed
  • Nickerson P, Steurer W, Steiger J, Zheng X, Steele AW, Strom TB. Cytokines and the Th1/Th2 paradigm in transplantation. Curr Opin Immunol 1994; 6:757-64. PubMed
  • Suthanthiran M, Strom TB. Renal transplantation. N Engl J Med 1994; 331:365-76. PubMed
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