Photo of Thomas Darrah,  PhD

Thomas Darrah, PhD

University Of Massachusetts - Boston

University Of Massachusetts - Boston
Phone: (570) 205-7533


darrah.24@osu.edu

Thomas Darrah, PhD

University Of Massachusetts - Boston

EDUCATIONAL TITLES

  • Assistant Professor, Environmental, Earth and Ocean Sciences, University Of Massachusetts - Boston

DF/HCC PROGRAM AFFILIATION

Research Abstract

In general, my research focuses on medical, environmental, and biometal chemistry utilizing elemental and isotopic mass spectrometric techniques traditionally rooted in geochemistry. My research interests focus on a fundamental understanding of the interactions between geological and anthropogenic contaminant materials in the environment and their bioincorporation and impact on human health. Specific, applications explore how metal composition has changed in the environment and in the body as anthropogenic metal use has changed over time. Additionally, my research focuses on the fate, transport, and bioincorporation of metals from metallodrug therapies, the potential impacts of metals and organo-metallic compounds on specific tissue reservoirs (e.g. bone), and the biokinetics and processes of metal transport from the mother to the placenta and fetus. These activities routinely include developing and validating inductively coupled plasma-MS (ICP-MS) instrumentation, compound specific (speciation) analysis (e.g., GC, IC, HPLC, laser ablation (LA), & cryogenic LA), and their respective methodologies. . Additionally, I run a CLIA-certified clinical laboratory for biometals analysis.

Publications

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  • Kravchenko J, Darrah TH, Miller RK, Lyerly HK, Vengosh A. A review of the health impacts of barium from natural and anthropogenic exposure. Environ Geochem Health 2014. PubMed
  • Sotiriou GA, Watson C, Murdaugh KM, Darrah TH, Pyrgiotakis G, Elder A, Brain JD, Demokritou P. Engineering safer-by-design, transparent, silica-coated ZnO nanorods with reduced DNA damage potential. Environ Sci Nano 2014; 1:144-153. PubMed
  • Vengosh A, Jackson RB, Warner N, Darrah TH, Kondash A. A Critical Review of the Risks to Water Resources from Unconventional Shale Gas Development and Hydraulic Fracturing in the United States. Environ Sci Technol 2014. PubMed
  • Jackson RB, Vengosh A, Darrah TH, Warner NR, Down A, Poreda RJ, Osborn SG, Zhao K, Karr JD. Increased stray gas abundance in a subset of drinking water wells near Marcellus shale gas extraction. Proc Natl Acad Sci U S A 2013; 110:11250-5. PubMed
  • Cuoco E, Tedesco D, Poreda RJ, Williams JC, De Francesco S, Balagizi C, Darrah TH. Impact of volcanic plume emissions on rain water chemistry during the January 2010 Nyamuragira eruptive event: implications for essential potable water resources. J Hazard Mater 2013; 244-245:570-81. PubMed
  • Tombline G, Schwingel JM, Lapek JD, Friedman AE, Darrah T, Maguire M, Van Alst NE, Filiatrault MJ, Iglewski BH. Pseudomonas aeruginosa PA1006 is a persulfide-modified protein that is critical for molybdenum homeostasis. PLoS ONE 2013; 8:e55593. PubMed
  • Warner NR, Jackson RB, Darrah TH, Osborn SG, Down A, Zhao K, White A, Vengosh A. Geochemical evidence for possible natural migration of Marcellus Formation brine to shallow aquifers in Pennsylvania. Proc Natl Acad Sci U S A 2012; 109:11961-6. PubMed
  • Sprauten M, Darrah TH, Peterson DR, Campbell ME, Hannigan RE, Cvancarova M, Beard C, Haugnes HS, FossÃ¥ SD, Oldenburg J, Travis LB. Impact of long-term serum platinum concentrations on neuro- and ototoxicity in Cisplatin-treated survivors of testicular cancer. J Clin Oncol 2012; 30:300-7. PubMed
  • McLaughlin MP, Darrah TH, Holland PL. Palladium(II) and platinum(II) bind strongly to an engineered blue copper protein. Inorg Chem 2011; 50:11294-6. PubMed
  • Darrah TH, Prutsman-Pfeiffer JJ, Poreda RJ, Ellen Campbell M, Hauschka PV, Hannigan RE. Incorporation of excess gadolinium into human bone from medical contrast agents. Metallomics 2011; 1:479-88. PubMed
  • R. B. Firestonea,b, A. Westc, J. P. Kennettd, L. Beckere, T. E. Bunchf, Z. S. Revayg, P. H. Schultzh, T. Belgyag, D. J. Kennetti,. Evidence for an extraterrestrial impact 12,900 years ago that contributed to the megafaunal extinctions and the Younger Dryas cooling Proc Natl Acad Sci U S A 2007; 104:16016-16021.