Photo of Thomas F. DeLaney,  MD

Thomas F. DeLaney, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-7869
Fax: (617) 724-9532


tdelaney@partners.org

Thomas F. DeLaney, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Andres Soriano Professor of Radiation Oncology, Radiation Oncology, Harvard Medical School
  • Medical Director, Francis H. Burr Proton Therapy Center, Radiation Oncology, Massachusetts General Hospital
  • Co-Director, Connective Tissue Oncology Center, Massachusetts General Hospital

DF/HCC ASSOCIATIONS

  • Member, Clinical Science Coordinating Committee

Research Abstract

My major areas of research activity have been in development and conduct of clinical trials in the management of localized sarcomas of bone and soft tissue. This includes the development and testing of innovative radiation therapy treatment approaches including charged particle radiation, interdigitated chemoradiation, and novel brachytherapy applicators, often in conjunction with surgery.

Publications

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  • Kelly KJ, Yoon SS, Kuk D, Qin LX, Dukleska K, Chang KK, Chen YL, Delaney TF, Brennan MF, Singer S. Comparison of Perioperative Radiation Therapy and Surgery Versus Surgery Alone in 204 Patients With Primary Retroperitoneal Sarcoma: A Retrospective 2-Institution Study. Ann Surg 2015; 262:156-62. PubMed
  • Baldini EH, Wang D, Haas RL, Catton CN, Indelicato DJ, Kirsch DG, Roberge D, Salerno K, Deville C, Guadagnolo BA, O'Sullivan B, Petersen IA, Le Pechoux C, Abrams RA, DeLaney TF. Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel. Int J Radiat Oncol Biol Phys 2015; 92:602-612. PubMed
  • Hull MA, Niemierko A, Haynes AB, Jacobson A, Chen YL, DeLaney TF, Mullen JT. Post-operative renal function following nephrectomy as part of en bloc resection of retroperitoneal sarcoma (RPS). J Surg Oncol 2015; 112:98-102. PubMed
  • Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona DM, DeLaney TF, Han T, Ma Y, Luo L, Ilkayeva OR, Lui K, Nichols AG, Newgard CB, Kastan MB, Rathmell JC, Dewhirst MW, Kirsch DG. HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. Radiat Res 2015; 183:594-609. PubMed
  • Baldini EH, Bosch W, Kane JM, Abrams RA, Salerno KE, Deville C, Raut CP, Petersen IA, Chen YL, Mullen JT, Millikan KW, Karakousis G, Kendrick ML, DeLaney TF, Wang D. Retroperitoneal Sarcoma (RPS) High Risk Gross Tumor Volume Boost (HR GTV Boost) Contour Delineation Agreement Among NRG Sarcoma Radiation and Surgical Oncologists. Ann Surg Oncol 2015. PubMed
  • Phukan R, Herzog T, Boland PJ, Healey J, Rose P, Sim FH, Yazsemski M, Hess K, Osler P, DeLaney TF, Chen YL, Hornicek F, Schwab J. How Does the Level of Sacral Resection for Primary Malignant Bone Tumors Affect Physical and Mental Health, Pain, Mobility, Incontinence, and Sexual Function? Clin Orthop Relat Res 2015. PubMed
  • De Amorim Bernstein K, Delaney TF. Role of radiation therapy for non-extremity soft tissue sarcomas. J Surg Oncol 2015; 111:604-14. PubMed
  • Wang D, Zhang Q, Eisenberg BL, Kane JM, Li XA, Lucas D, Petersen IA, DeLaney TF, Freeman CR, Finkelstein SE, Hitchcock YJ, Bedi M, Singh AK, Dundas G, Kirsch DG. Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial. J Clin Oncol 2015. PubMed
  • Kambadakone A, Yoon SS, Kim TM, Karl DL, Duda DG, DeLaney TF, Sahani DV. CT perfusion as an imaging biomarker in monitoring response to neoadjuvant bevacizumab and radiation in soft-tissue sarcomas: comparison with tumor morphology, circulating and tumor biomarkers, and gene expression. AJR Am J Roentgenol 2014; 204:W11-8. PubMed
  • Cheney MD, Chen YL, Lim R, Winrich BK, Grosu AL, Trofimov AV, Depauw N, Shih HA, Schwab JH, Hornicek FJ, DeLaney TF. [18F]-Fluoromisonidazole positron emission tomography/computed tomography visualization of tumor hypoxia in patients with chordoma of the mobile and sacrococcygeal spine. Int J Radiat Oncol Biol Phys 2014; 90:1030-6. PubMed
  • Yock TI, Bhat S, Szymonifka J, Yeap BY, Delahaye J, Donaldson SS, MacDonald SM, Pulsifer MB, Hill KS, DeLaney TF, Ebb D, Huang M, Tarbell NJ, Fisher PG, Kuhlthau KA. Quality of life outcomes in proton and photon treated pediatric brain tumor survivors. Radiother Oncol 2014. PubMed
  • Pan E, Goldberg SI, Chen YL, Giraud C, Hornick JL, Nielsen GP, Hornicek FJ, Raut CP, DeLaney TF, Baldini EH. Role of post-operative radiation boost for soft tissue sarcomas with positive margins following pre-operative radiation and surgery. J Surg Oncol 2014. PubMed
  • Mullen JT, Hornicek FJ, Harmon DC, Raskin KA, Chen YL, Szymonifka J, Yeap BY, Choy E, DeLaney TF, Nielsen GP. Prognostic significance of treatment-induced pathologic necrosis in extremity and truncal soft tissue sarcoma after neoadjuvant chemoradiotherapy. Cancer 2014. PubMed
  • von Mehren M, Randall RL, Benjamin RS, Boles S, Bui MM, Casper ES, Conrad EU, DeLaney TF, Ganjoo KN, George S, Gonzalez RJ, Heslin MJ, Kane JM, Mayerson J, McGarry SV, Meyer C, O'Donnell RJ, Pappo AS, Paz IB, Pfeifer JD, Riedel RF, Schuetze S, Schupak KD, Schwartz HS, Van Tine BA, Wayne JD, Bergman MA, Sundar H. Gastrointestinal stromal tumors, version 2.2014. J Natl Compr Canc Netw 2014; 12:853-62. PubMed
  • Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, Wadlow RC, Kwak EL, Allen JN, Clark JW, Zhu AX, Ferrone CR, Mamon HJ, Adams J, Winrich B, Grillo T, Jain RK, DeLaney TF, Fernandez-Del Castillo C, Duda DG. A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma. Int J Radiat Oncol Biol Phys 2014. PubMed
  • Cheney MD, Giraud C, Goldberg SI, Rosenthal DI, Hornicek FJ, Choy E, Mullen JT, Chen YL, Delaney TF. MRI surveillance following treatment of extremity soft tissue sarcoma. J Surg Oncol 2014; 109:593-6. PubMed
  • Delaney TF, Liebsch NJ, Pedlow FX, Adams J, Weyman EA, Yeap BY, Depauw N, Nielsen GP, Harmon DC, Yoon SS, Chen YL, Schwab JH, Hornicek FJ. Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas. J Surg Oncol 2014. PubMed
  • von Mehren M, Randall RL, Benjamin RS, Boles S, Bui MM, Casper ES, Conrad EU, Delaney TF, Ganjoo KN, George S, Gonzalez RJ, Heslin MJ, Kane JM, Mayerson J, McGarry SV, Meyer C, O'Donnell RJ, Pappo AS, Paz IB, Pfeifer JD, Riedel RF, Schuetze S, Schupak KD, Schwartz HS, Van Tine BA, Wayne JD, Bergman MA, Sundar H. Soft tissue sarcoma, version 2.2014. J Natl Compr Canc Netw 2014; 12:473-83. PubMed
  • Boyaci B, Hornicek FJ, Nielsen GP, DeLaney TF, Pedlow FX, Mansfield FL, Carrier CS, Harms J, Schwab JH. Epithelioid hemangioma of the spine: a case series of six patients and review of the literature. Spine J 2013; 13:e7-13. PubMed
  • Macdonald SM, Patel SA, Hickey S, Specht M, Isakoff SJ, Gadd M, Smith BL, Yeap BY, Adams J, Delaney TF, Kooy H, Lu HM, Taghian AG. Proton Therapy for Breast Cancer After Mastectomy: Early Outcomes of a Prospective Clinical Trial. Int J Radiat Oncol Biol Phys 2013. PubMed
  • Bahig H, Roberge D, Bosch W, Levin W, Petersen I, Haddock M, Freeman C, Delaney TF, Abrams RA, Indelicato DJ, Baldini EH, Hitchcock Y, Kirsch DG, Kozak KR, Wolfson A, Wang D. Agreement Among RTOG Sarcoma Radiation Oncologists in Contouring Suspicious Peritumoral Edema for Preoperative Radiation Therapy of Soft Tissue Sarcoma of the Extremity. Int J Radiat Oncol Biol Phys 2013. PubMed
  • Macdonald SM, Jimenez R, Paetzold P, Adams J, Beatty J, Delaney TF, Kooy H, Taghian AG, Lu HM. Proton radiotherapy for chest wall and regional lymphatic radiation; dose comparisons and treatment delivery. Radiat Oncol 2013; 8:71. PubMed
  • Mullen JT, DeLaney TF, Rosenberg AE, Le L, Iafrate AJ, Kobayashi W, Szymonifka J, Yeap BY, Chen YL, Harmon DC, Choy E, Yoon SS, Raskin KA, Hornicek FJ, Nielsen GP. 硫-Catenin mutation status and outcomes in sporadic desmoid tumors. Oncologist 2013; 18:1043-9. PubMed
  • Kang J, Botros M, Goldberg S, Giraud C, Nielsen GP, Chen YL, Raskin K, Schwab J, Yoon SS, Hornicek FJ, Delaney TF. The use of radiation therapy in the management of selected patients with atypical lipomas. Sarcoma 2013; 2013:485483. PubMed
  • Rochet N, Kahn RS, Niemierko A, Delaney TF, Russell AH. Consolidation whole abdomen irradiation following adjuvant carboplatin-paclitaxel based chemotherapy for advanced uterine epithelial cancer: feasibility, toxicity and outcomes. Radiat Oncol 2013; 8:236. PubMed
  • Haas RL, Delaney TF, O'Sullivan B, Keus RB, Le Pechoux C, Olmi P, Poulsen JP, Seddon B, Wang D. Radiotherapy for management of extremity soft tissue sarcomas: why, when, and where? Int J Radiat Oncol Biol Phys 2012; 84:572-80. PubMed
  • Dunn GP, Spiliopoulos K, Plotkin SR, Hornicek FJ, Harmon DC, Delaney TF, Williams Z. Role of resection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis Type 1. J Neurosurg 2012. PubMed
  • Hong NJ, Hornicek FJ, Harmon DC, Choy E, Chen YL, Yoon SS, Nielsen GP, Szymonifka J, Yeap BY, Delaney TF, Mullen JT. Neoadjuvant chemoradiotherapy for patients with high-risk extremity and truncal sarcomas: A 10-year single institution retrospective study. Eur J Cancer 2012. PubMed
  • Wang D, Bosch W, Roberge D, Finkelstein SE, Petersen I, Haddock M, Chen YL, Delaney TF, Saito NG, Kirsch DG, Hitchcock YJ, Wolfson AH. In Reply to O'Sullivan et al. Int J Radiat Oncol Biol Phys 2012; 84:307-8. PubMed
  • Mullen JT, Delaney TF, Kobayashi WK, Szymonifka J, Yeap BY, Chen YL, Rosenberg AE, Harmon DC, Choy E, Yoon SS, Raskin KA, Petur Nielsen G, Hornicek FJ. Desmoid Tumor: Analysis of Prognostic Factors and Outcomes in a Surgical Series. Ann Surg Oncol 2012. PubMed
  • Look Hong NJ, Hornicek FJ, Raskin KA, Yoon SS, Szymonifka J, Yeap B, Chen YL, Delaney TF, Nielsen GP, Mullen JT. Prognostic Factors and Outcomes of Patients with Myxofibrosarcoma. Ann Surg Oncol 2012. PubMed
  • von Mehren M, Benjamin RS, Bui MM, Casper ES, Conrad EU, DeLaney TF, Ganjoo KN, George S, Gonzalez R, Heslin MJ, Kane JM, Mayerson J, McGarry SV, Meyer C, O'Donnell RJ, Paz B, Pfeifer JD, Pollock RE, Randall RL, Riedel RF, Schuetze S, Schupak KD, Schwartz HS, Shankar S, Van Tine BA, Wayne J, Sundar H, McMillian NR. Soft tissue sarcoma, version 2.2012: featured updates to the NCCN guidelines. J Natl Compr Canc Netw 2012; 10:951-60. PubMed
  • Trofimov A, Unkelbach J, Delaney TF, Bortfeld T. Visualization of a variety of possible dosimetric outcomes in radiation therapy using dose-volume histogram bands. 2012; 2:164-171. PubMed
  • Ciernik IF, Niemierko A, Harmon DC, Kobayashi W, Chen YL, Yock TI, Ebb DH, Choy E, Raskin KA, Liebsch N, Hornicek FJ, Delaney TF. Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma. Cancer 2011. PubMed
  • Engelsman M, Delaney TF, Hong TS. Proton Radiotherapy: The Biological Effect of Treating Alternating Subsets of Fields for Different Treatment Fractions. Int J Radiat Oncol Biol Phys 2011; 79:616-22. PubMed
  • Wang D, Bosch W, Kirsch DG, Al Lozi R, El Naqa I, Roberge D, Finkelstein SE, Petersen I, Haddock M, Chen YL, Saito NG, Hitchcock YJ, Wolfson AH, Delaney TF. Variation in the Gross Tumor Volume and Clinical Target Volume for Preoperative Radiotherapy of Primary Large High-Grade Soft Tissue Sarcoma of the Extremity Among Rtog Sarcoma Radiation Oncologists. Int J Radiat Oncol Biol Phys 2011. PubMed
  • Hong TS, Ryan DP, Blaszkowsky LS, Mamon HJ, Kwak EL, Mino-Kenudson M, Adams J, Yeap B, Winrich B, Delaney TF, Fernandez-Del Castillo C. Phase I Study of Preoperative Short-Course Chemoradiation with Proton Beam Therapy and Capecitabine for Resectable Pancreatic Ductal Adenocarcinoma of the Head. Int J Radiat Oncol Biol Phys 2010; 79:151-7. PubMed
  • Tejwani A, Kobayashi W, Chen YL, Rosenberg AE, Yoon S, Raskin KA, Rosenthal DI, Nielsen GP, Hornicek FJ, Delaney TF. Management of acral myxoinflammatory fibroblastic sarcoma. Cancer 2010; 116:5733-9. PubMed
  • DeLaney TF, Duan Z, Hornicek FJ. Proteomic profiling of chordoma. J Surg Oncol 2010; 102:719. PubMed
  • Yoon SS, Duda DG, Karl DL, Kim TM, Kambadakone AR, Chen YL, Rothrock C, Rosenberg AE, Nielsen GP, Kirsch DG, Choy E, Harmon DC, Hornicek FJ, Dreyfuss J, Ancukiewicz M, Sahani DV, Park PJ, Jain RK, Delaney TF. Phase II Study of Neoadjuvant Bevacizumab and Radiotherapy for Resectable Soft Tissue Sarcomas. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Kraybill WG, Harris J, Spiro IJ, Ettinger DS, DeLaney TF, Blum RH, Lucas DR, Harmon DC, Letson GD, Eisenberg B. Long-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. Cancer 2010; 116:4613-21. PubMed
  • Devisetty K, Kobayashi W, Suit HD, Goldberg SI, Niemierko A, Chen YL, Raskin KA, Schwab JH, Springfield DS, Yoon SS, Hornicek FJ, Delaney TF. Low-Dose Neoadjuvant External Beam Radiation Therapy for Soft Tissue Sarcoma. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Schoenfeld AJ, Hornicek FJ, Pedlow FX, Kobayashi W, Garcia RT, DeLaney TF, Springfield D, Mankin HJ, Schwab JH. Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital. Spine J 2010; 10:708-14. PubMed
  • Kim B, Chen YL, Kirsch DG, Goldberg SI, Kobayashi W, Hyun Kung J, Wolfgang JA, Doppke K, Rosenberg AE, Nielsen GP, Raskin KA, Springfield DS, Schwab JH, Gebhardt MC, Yoon SS, Hornicek FJ, Delaney TF. An Effective Preoperative Three-Dimensional Radiotherapy Target Volume for Extremity Soft Tissue Sarcoma and the Effect of Margin Width on Local Control. Int J Radiat Oncol Biol Phys 2010; 77:843-50. PubMed
  • Demetri GD, Antonia S, Benjamin RS, Bui MM, Casper ES, Conrad EU, Delaney TF, Ganjoo KN, Heslin MJ, Hutchinson RJ, Kane JM, Letson GD, McGarry SV, O'Donnell RJ, Paz IB, Pfeifer JD, Pollock RE, Randall RL, Riedel RF, Schupak KD, Schwartz HS, Thornton K, von Mehren M, Wayne J. Soft tissue sarcoma. J Natl Compr Canc Netw 2010; 8:630-74. PubMed
  • Yoon SS, Chen YL, Kirsch DG, Maduekwe UN, Rosenberg AE, Nielsen GP, Sahani DV, Choy E, Harmon DC, Delaney TF. Proton-Beam, Intensity-Modulated, and/or Intraoperative Electron Radiation Therapy Combined with Aggressive Anterior Surgical Resection for Retroperitoneal Sarcomas. Ann Surg Oncol 2010; 17:1515-29. PubMed
  • Kooy HM, Clasie BM, Lu HM, Madden TM, Bentefour H, Depauw N, Adams JA, Trofimov AV, Demaret D, Delaney TF, Flanz JB. A case study in proton pencil-beam scanning delivery. Int J Radiat Oncol Biol Phys 2010; 76:624-30. PubMed
  • Hong TS, DeLaney TF, Mamon HJ, Willett CG, Yeap BY, Niemierko A, Wolfgang JA, Lu HM, Adams J, Weyman EA, Arellano RS, Blaszkowsky LS, Allen JN, Tanabe KK, Ryan DP, Zhu AX. A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors. 2014; 4:316-22. PubMed
  • Holloway CL, Delaney TF, Alektiar KM, Devlin PM, O'Farrell DA, Demanes DJ. American Brachytherapy Society (ABS) consensus statement for sarcoma brachytherapy. Brachytherapy 2013; 12:179-90. PubMed
  • Yoon SS, Chen YL, Kambadakone A, Schmidt B, Delaney TF. Surgical placement of biologic mesh spacers prior to external beam radiation for retroperitoneal and pelvic tumors. 2014; 3:199-208. PubMed
  • Gierga DP, Turcotte JC, Tong LW, Chen YL, DeLaney TF. Analysis of setup uncertainties for extremity sarcoma patients using surface imaging. 2014; 4:261-6. PubMed
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