Photo of Thomas N. Byrne,  MD

Thomas N. Byrne, MD

Massachusetts General Hospital

Massachusetts General Hospital

Thomas N. Byrne, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Neurology, Harvard Medical School
  • Neurologist, Neurology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My principal clinical and research interests include the neurological complications of cancer and anticancer therapy. I has written several articles in the neurology and neuro-oncology literature and is first author of two books devoted to diseases of the spine and spinal cord. More recently, my interests are directed to the intersection of neuroscience and oncology, specifically, the mechanism and prevention of cognitive and other neurological deficits in cancer patients. Laboratory studies have shown that neurogenesis in the hippocampus plays a role in memory and emotion. Since anticancer treatments such as radiation and chemotherapy can inhibit neurogenesis, this may be a mechanism for these deficits. Strategies to prevent the inhibition of neurogenesis might lead to prevention of such cognitive problems and improve the lives of cancer survivors.

Publications

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  • Ramsey CR, Scaperoth D, Seibert R, Chase D, Byrne T, Mahan S. Image-guided helical tomotherapy for localized prostate cancer: technique and initial clinical observations. J Appl Clin Med Phys 2007; 8:2320. PubMed
  • Batchelor TT, Byrne TN. Supportive care of brain tumor patients. Hematol Oncol Clin North Am 2006; 20:1337-61. PubMed
  • Byrne TN, Borges LF, Loeffler JS. Metastatic epidural spinal cord compression: update on management. Semin Oncol 2006; 33:307-11. PubMed
  • Byrne TN. Cognitive sequelae of brain tumor treatment. Curr Opin Neurol 2005; 18:662-6. PubMed
  • Byrne TN. Response of low-grade oligodendroglial tumors to temozolomide. J Neurooncol 2005; 70:279-80. PubMed
  • Byrne TN. Metastatic epidural cord compression. Curr Neurol Neurosci Rep 2004; 4:191-5. PubMed