Photo of Thomas S. Deisboeck,  MD

Thomas S. Deisboeck, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-1845
Fax: (617) 726-5079


deisboec@helix.mgh.harvard.edu

Thomas S. Deisboeck, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School
  • Associate Professor, Radiology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Publications

Powered by Harvard Catalyst
  • Wang Z, Butner JD, Cristini V, Deisboeck TS. Integrated PK-PD and agent-based modeling in oncology. J Pharmacokinet Pharmacodyn 2015; 42:179-89. PubMed
  • Wang Z, Butner JD, Kerketta R, Cristini V, Deisboeck TS. Simulating cancer growth with multiscale agent-based modeling. Semin Cancer Biol 2014. PubMed
  • Wang Z, Deisboeck TS. Mathematical modeling in cancer drug discovery. Drug Discov Today 2014; 19:145-50. PubMed
  • Sfakianakis S, Sakkalis V, Marias K, Stamatakos G, McKeever S, Deisboeck TS, Graf N. An architecture for integrating cancer model repositories. Conf Proc IEEE Eng Med Biol Soc 2013; 2012:6628-31. PubMed
  • Wang Z, Bordas V, Sagotsky J, Deisboeck TS. Identifying therapeutic targets in a combined EGFR-TGF{beta}R signalling cascade using a multiscale agent-based cancer model. 2010. PubMed
  • Chen LL, Ulmer S, Deisboeck TS. An agent-based model identifies MRI regions of probable tumor invasion in a patient with glioblastoma. Phys Med Biol 2009; 55:329-38. PubMed
  • Castorina P, Carcò D, Guiot C, Deisboeck TS. Tumor growth instability and its implications for chemotherapy. Cancer Res 2009; 69:8507-15. PubMed
  • Wang Z, Birch CM, Sagotsky J, Deisboeck TS. Cross-scale, cross-pathway evaluation using an agent-based non-small cell lung cancer model. Bioinformatics 2009; 25:2389-96. PubMed
  • Zhang L,Wang Z,Sagotsky JA,Deisboeck TS. Multiscale agent-based cancer modeling. J Math Biol 2008; 58:545-59. PubMed
  • Chen LL,Zhang L,Yoon J,Deisboeck TS. Cancer cell motility: optimizing spatial search strategies. Biosystems 2008; 95:234-42. PubMed
  • Deisboeck TS,Couzin ID. Collective behavior in cancer cell populations. Bioessays 2009; 31:190-7. PubMed
  • Deisboeck TS,Zhang L,Yoon J,Costa J. In silico cancer modeling: is it ready for prime time? Nat Clin Pract Oncol 2008; 6:34-42. PubMed
  • Deisboeck TS. Personalizing medicine: a systems biology perspective. Mol Syst Biol 2009; 5:249. PubMed
  • Yoon J,Deisboeck TS. Investigating differential dynamics of the MAPK signaling cascade using a multi-parametric global sensitivity analysis. PLoS ONE 2009; 4:e4560. PubMed
  • Sole RV,Rodriguez-Caso C,Deisboeck TS,Saldana J. Cancer stem cells as the engine of unstable tumor progression. J Theor Biol 2008; 253:629-37. PubMed
  • Deisboeck TS. Cancer: A profit-driven biosystem? Med Hypotheses 2008; 71:186-9. PubMed
  • Wang Z, Birch CM, Deisboeck TS. Cross-scale sensitivity analysis of a non-small cell lung cancer model: Linking molecular signaling properties to cellular behavior. Biosystems 2008; 92:249-58. PubMed
  • Huang S, Vader D, Wang Z, Stemmer-Rachamimov A, Weitz DA, Dai G, Rosen BR, Deisboeck TS. Using magnetic resonance microscopy to study the growth dynamics of a glioma spheroid in collagen I: A case study. BMC Med Imaging 2008; 8:3. PubMed
  • Deisboeck TS, Guiot C. Surgical impact on brain tumor invasion: A physical perspective. Ann Surg Innov Res 2008; 2:1. PubMed
  • Deisboeck TS,Wang Z. A new concept for cancer therapy: out-competing the aggressor. Cancer Cell Int 2008; 8:19. PubMed
  • Guiot C, Pugno N, Delsanto PP, Deisboeck TS. Physical aspects of cancer invasion. Phys Biol 2008; 4:P1-6. PubMed
  • Castorina P, Deisboeck TS, Gabriele P, Guiot C. Growth laws in cancer: implications for radiotherapy. Radiat Res 2007; 168:349-56. PubMed
  • Zhang L, Athale CA, Deisboeck TS. Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer. J Theor Biol 2006; 244:96-107. PubMed
  • Wang Z, Zhang L, Sagotsky J, Deisboeck TS. Simulating non-small cell lung cancer with a multiscale agent-based model. Theor Biol Med Model 2007; 4:50. PubMed
  • Guiot C, Delsanto PP, Carpinteri A, Pugno N, Mansury Y, Deisboeck TS. The dynamic evolution of the power exponent in a universal growth model of tumors. J Theor Biol 2005; 240:459-63. PubMed
  • Athale CA, Deisboeck TS. The effects of EGF-receptor density on multiscale tumor growth patterns. J Theor Biol 2005; 238:771-9. PubMed
  • Athale C, Mansury Y, Deisboeck TS. Simulating the impact of a molecular 'decision-process' on cellular phenotype and multicellular patterns in brain tumors. J Theor Biol 2005; 233:469-81. PubMed
  • Guiot C, Degiorgis PG, Delsanto PP, Gabriele P, Deisboeck TS. Does tumor growth follow a "universal law"? J Theor Biol 2003; 225:147-51. PubMed
  • Wang Z, Sagotsky J, Taylor T, Shironoshita P, Deisboeck TS. Accelerating cancer systems biology research through Semantic Web technology. 2013; 5:135-51. PubMed
Hide