Photo of Tianxi Cai,  DSc

Tianxi Cai, DSc

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-1056


tcai@hsph.harvard.edu

Tianxi Cai, DSc

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Professor, Biostatistics, Harvard T.H. Chan School Of Public Health

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Cai's current research interests are mainly in the area of survival data including clustered failure time data, doubly censored and interval censored data; evaluating the accuracy of biomarkers for predicting clinical outcomes and treatment responses; robust model evaluation and model selection.

Publications

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  • Parast L, Tian L, Cai T. Landmark Estimation of Survival and Treatment Effect in a Randomized Clinical Trial. Journal of the American Statistical Association 2014; 109:384-394. PubMed
  • Sinnott JA, Cai T. Omnibus risk assessment via accelerated failure time kernel machine modeling. Biometrics 2013; 69:861-73. PubMed
  • Altschuler GM, Hofmann O, Kalatskaya I, Payne R, Ho Sui SJ, Saxena U, Krivtsov AV, Armstrong SA, Cai T, Stein L, Hide WA. Pathprinting: An integrative approach to understand the functional basis of disease. Genome Med 2013; 5:68. PubMed
  • Gail MH, Pfeiffer RM, Cai T. Editorial. Lifetime Data Analysis 2013; 19:139-41. PubMed
  • Parast L, Cai T. Landmark risk prediction of residual life for breast cancer survival. Stat Med 2013. PubMed
  • Zhou QM, Zheng Y, Cai T. Assessment of biomarkers for risk prediction with nested case-control studies. Clin Trials 2013; 10:677-9. PubMed
  • Liu D, Cai T, Zheng Y. Evaluating the Predictive Value of Biomarkers with Stratified Case-Cohort Design. Biometrics 2012. PubMed
  • Uno H, Tian L, Cai T, Kohane IS, Wei LJ. A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data. Stat Med 2012. PubMed
  • Cai T, Lin X, Carroll RJ. Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics 2012; 13:776-90. PubMed
  • Parast L, Cheng SC, Cai T. Landmark Prediction of Long Term Survival Incorporating Short Term Event Time Information. Journal of the American Statistical Association 2013; 107:1492-1501. PubMed
  • Parast L, Cheng SC, Cai T. Incorporating short-term outcome information to predict long-term survival with discrete markers. Biom J 2011; 53:294-307. PubMed
  • Cai T, Tonini G, Lin X. Kernel Machine Approach to Testing the Significance of Multiple Genetic Markers for Risk Prediction. Biometrics 2011. PubMed
  • Uno H, Cai T, Pencina MJ, D'Agostino RB, Wei LJ. On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data. Stat Med 2011. PubMed
  • Cai T, Tian L, Wong PH, Wei LJ. Analysis of randomized comparative clinical trial data for personalized treatment selections. Biostatistics 2010. PubMed
  • Cai T, Parast L, Ryan L. Meta-analysis for rare events. Stat Med 2010; 29:2078-89. PubMed
  • Hunsaker AR, Oliva IB, Cai T, Trotman-Dickenson B, Gill RR, Hatabu H, Rybicki FJ. Contrast opacification using a reduced volume of iodinated contrast material and low peak kilovoltage in pulmonary CT angiography: Objective and subjective evaluation. AJR Am J Roentgenol 2010; 195:W118-24. PubMed
  • Cai T, Gerds TA, Zheng Y, Chen J. Robust Prediction of t-Year Survival with Data from Multiple Studies. Biometrics 2010. PubMed
  • Zheng Y,Cai T,Stanford JL,Feng Z. Semiparametric Models of Time-Dependent Predictive Values of Prognostic Biomarkers. Biometrics 2010; 66:50-60. PubMed
  • Tian L, Cai T, Wei LJ. Identifying subjects who benefit from additional information for better prediction of the outcome variables. Biometrics 2009; 65:894-902. PubMed
  • Cai T, Huang J, Tian L. Regularized estimation for the accelerated failure time model. Biometrics 2009; 65:394-404. PubMed
  • Tian L,Cai T,Pfeffer MA,Piankov N,Cremieux PY,Wei LJ. Exact and efficient inference procedure for meta-analysis and its application to the analysis of independent 2 x 2 tables with all available data but without artificial continuity correction. Biostatistics 2008; 10:275-81. PubMed
  • Wu CJ, Cai T, Rikova K, Merberg D, Kasif S, Steffen M. A predictive phosphorylation signature of lung cancer. PLoS ONE 2009; 4:e7994. PubMed
  • Gerds TA,Cai T,Schumacher M. The performance of risk prediction models. Biom J 2008; 50:457-79. PubMed
  • Cai T,Cheng S. Robust combination of multiple diagnostic tests for classifying censored event times. Biostatistics 2007; 9:216-33. PubMed
  • Zheng Y, Cai T, Pepe MS, Levy WC. Time-dependent Predictive Values of Prognostic Biomarkers with Failure Time Outcome. Journal of the American Statistical Association 2009; 103:362-368. PubMed
  • Ersoy H, Goldhaber SZ, Cai T, Luu T, Rosebrook J, Mulkern R, Rybicki F. Time-resolved MR angiography: a primary screening examination of patients with suspected pulmonary embolism and contraindications to administration of iodinated contrast material. AJR Am J Roentgenol 2007; 188:1246-54. PubMed
  • Cai T, Zheng Y. Model checking for ROC regression analysis. Biometrics 2007; 63:152-63. PubMed
  • Chuang SK, Cai T. Predicting clustered dental implant survival using frailty methods. J Dent Res 2006; 85:1147-51. PubMed
  • Cai T, Pepe MS, Zheng Y, Lumley T, Jenny NS. The sensitivity and specificity of markers for event times. Biostatistics 2005; 7:182-97. PubMed
  • Zheng Y, Cai T, Feng Z. Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers. Biometrics 2006; 62:279-87. PubMed
  • Cai T, Gilbert PB, Self SG. Joint inferences on vaccine efficacy against infection and disease with application to the first HIV vaccine efficacy trial. J Biopharm Stat 2006; 16:517-38. PubMed
  • Cai T, Moskowitz CS. Semi-parametric estimation of the binormal ROC curve for a continuous diagnostic test. Biostatistics 2004; 5:573-86. PubMed
  • Pepe MS, Cai T. The analysis of placement values for evaluating discriminatory measures. Biometrics 2004; 60:528-35. PubMed
  • Cai T, Betensky RA. Hazard regression for interval-censored data with penalized spline. Biometrics 2003; 59:570-9. PubMed
  • Tian L, Cai T, Goetghebeur E, Wei LJ. Model Evaluation Based on the Distribution of Estimated Absolute Prediction Error 2007; 94:297-311.
  • Cai T, Tian L, Uno H, Solomon SD, Wei LJ. Calibrating parametric subject-specific risk estimation Biometrika 2010; 97:389-404.
  • Ware J, Cai T. Comments on Evaluation the added predictive ability of a new markier: From area under the ROC curve to reclassification and beyond 2007; 27:185-187.
  • Uno H, Cai T, Tian L, Wei LJ. Evaluating Prediction Rules for t-Year Survivors With Censored Regression Models J Am Stat Assoc 2007; 102:527-37.
  • Cai T, Tian L, Solomon S, Wei LJ. Predicting Future Responses Based on Possibly Misspecified Working Models 2008; 95:75-92.
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