Photo of Tianxi Cai,  DSc

Tianxi Cai, DSc

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-1056


tcai@hsph.harvard.edu

Tianxi Cai, DSc

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Professor, Biostatistics, Harvard T.H. Chan School Of Public Health

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Cai's current research interests are mainly in the area of survival data including clustered failure time data, doubly censored and interval censored data; evaluating the accuracy of biomarkers for predicting clinical outcomes and treatment responses; robust model evaluation and model selection.

Publications

Powered by Harvard Catalyst
  • Minnier J, Yuan M, Liu JS, Cai T. Risk Classification with an Adaptive Naive Bayes Kernel Machine Model. Journal of the American Statistical Association 2015; 110:393-404. PubMed
  • Shen Y, Liao KP, Cai T. Sparse kernel machine regression for ordinal outcomes. Biometrics 2015. PubMed
  • Parast L, Tian L, Cai T. Landmark Estimation of Survival and Treatment Effect in a Randomized Clinical Trial. Journal of the American Statistical Association 2014; 109:384-394. PubMed
  • Sinnott JA, Cai T. Omnibus risk assessment via accelerated failure time kernel machine modeling. Biometrics 2013; 69:861-73. PubMed
  • Zhou QM, Zheng Y, Cai T. Assessment of biomarkers for risk prediction with nested case-control studies. Clin Trials 2013; 10:677-9. PubMed
  • Parast L, Cai T. Landmark risk prediction of residual life for breast cancer survival. Stat Med 2013. PubMed
  • Uno H, Tian L, Cai T, Kohane IS, Wei LJ. A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data. Stat Med 2013. PubMed
  • Gail MH, Pfeiffer RM, Cai T. Six articles related to risk assessment and prediction based on work presented at the October 12–14, 2011 Conference on Risk Assessment and Evaluation of Predictions in Silver Spring, Maryland. Lifetime Data Analysis 2013; 19:139-41. PubMed
  • Altschuler GM, Hofmann O, Kalatskaya I, Payne R, Ho Sui SJ, Saxena U, Krivtsov AV, Armstrong SA, Cai T, Stein L, Hide WA. Pathprinting: An integrative approach to understand the functional basis of disease. Genome Med 2014; 5:68. PubMed
  • Liu D, Cai T, Zheng Y. Evaluating the predictive value of biomarkers with stratified case-cohort design. Biometrics 2013. PubMed
  • Cai T, Lin X, Carroll RJ. Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics 2012; 13:776-90. PubMed
  • Parast L, Cheng SC, Cai T. Landmark Prediction of Long Term Survival Incorporating Short Term Event Time Information. Journal of the American Statistical Association 2013; 107:1492-1501. PubMed
  • Cai T, Tonini G, Lin X. Kernel machine approach to testing the significance of multiple genetic markers for risk prediction. Biometrics 2011. PubMed
  • Parast L, Cheng SC, Cai T. Incorporating short-term outcome information to predict long-term survival with discrete markers. Biom J 2011; 53:294-307. PubMed
  • Uno H, Cai T, Pencina MJ, D'Agostino RB, Wei LJ. On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data. Stat Med 2011. PubMed
  • Cai T, Tian L, Wong PH, Wei LJ. Analysis of randomized comparative clinical trial data for personalized treatment selections. Biostatistics 2010. PubMed
  • Cai T, Parast L, Ryan L. Meta-analysis for rare events. Stat Med 2010; 29:2078-89. PubMed
  • Hunsaker AR, Oliva IB, Cai T, Trotman-Dickenson B, Gill RR, Hatabu H, Rybicki FJ. Contrast opacification using a reduced volume of iodinated contrast material and low peak kilovoltage in pulmonary CT angiography: Objective and subjective evaluation. AJR Am J Roentgenol 2010; 195:W118-24. PubMed
  • Cai T, Gerds TA, Zheng Y, Chen J. Robust Prediction of t-Year Survival with Data from Multiple Studies. Biometrics 2010. PubMed
  • Zheng Y,Cai T,Stanford JL,Feng Z. Semiparametric Models of Time-Dependent Predictive Values of Prognostic Biomarkers. Biometrics 2010; 66:50-60. PubMed
  • Tian L, Cai T, Wei LJ. Identifying subjects who benefit from additional information for better prediction of the outcome variables. Biometrics 2009; 65:894-902. PubMed
  • Cai T, Huang J, Tian L. Regularized estimation for the accelerated failure time model. Biometrics 2009; 65:394-404. PubMed
  • Tian L,Cai T,Pfeffer MA,Piankov N,Cremieux PY,Wei LJ. Exact and efficient inference procedure for meta-analysis and its application to the analysis of independent 2 x 2 tables with all available data but without artificial continuity correction. Biostatistics 2008; 10:275-81. PubMed
  • Wu CJ, Cai T, Rikova K, Merberg D, Kasif S, Steffen M. A predictive phosphorylation signature of lung cancer. PLoS ONE 2009; 4:e7994. PubMed
  • Gerds TA,Cai T,Schumacher M. The performance of risk prediction models. Biom J 2008; 50:457-79. PubMed
  • Cai T,Cheng S. Robust combination of multiple diagnostic tests for classifying censored event times. Biostatistics 2007; 9:216-33. PubMed
  • Zheng Y, Cai T, Pepe MS, Levy WC. Time-dependent Predictive Values of Prognostic Biomarkers with Failure Time Outcome. Journal of the American Statistical Association 2009; 103:362-368. PubMed
  • Ersoy H, Goldhaber SZ, Cai T, Luu T, Rosebrook J, Mulkern R, Rybicki F. Time-resolved MR angiography: a primary screening examination of patients with suspected pulmonary embolism and contraindications to administration of iodinated contrast material. AJR Am J Roentgenol 2007; 188:1246-54. PubMed
  • Cai T, Zheng Y. Model checking for ROC regression analysis. Biometrics 2007; 63:152-63. PubMed
  • Chuang SK, Cai T. Predicting clustered dental implant survival using frailty methods. J Dent Res 2006; 85:1147-51. PubMed
  • Zheng Y, Cai T, Feng Z. Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers. Biometrics 2006; 62:279-87. PubMed
  • Cai T, Gilbert PB, Self SG. Joint inferences on vaccine efficacy against infection and disease with application to the first HIV vaccine efficacy trial. J Biopharm Stat 2006; 16:517-38. PubMed
  • Ware J, Cai T. Comments on Evaluation the added predictive ability of a new markier: From area under the ROC curve to reclassification and beyond 2007; 27:185-187.
  • Tian L, Cai T, Goetghebeur E, Wei LJ. Model Evaluation Based on the Distribution of Estimated Absolute Prediction Error 2007; 94:297-311.
  • Uno H, Cai T, Tian L, Wei LJ. Evaluating Prediction Rules for t-Year Survivors With Censored Regression Models J Am Stat Assoc 2007; 102:527-37.
  • Cai T, Tian L, Solomon S, Wei LJ. Predicting Future Responses Based on Possibly Misspecified Working Models 2008; 95:75-92.
  • Cai T, Tian L, Uno H, Solomon SD, Wei LJ. Calibrating parametric subject-specific risk estimation Biometrika 2010; 97:389-404.
Hide