Our research focus is on the molecular basis of inflammation, in particular in its chronic state. Chronic inflammation contributes to common complex human diseases, including metabolic, cardiovascular, and neurodegenerative diseases and many cancers. In these settings, inflammation may be initially induced as an adaptive response to various forms of cellular and tissue stress (“para-inflammation”), but then becomes dysregulated for unknown reasons. We are interested in identifying the molecular signals that activate inflammation in non-infectious contexts and the inflammatory pathways that are engaged. We want to understand how these pathways intersect with other pathways for stress adaptation, how they become dysregulated, and how they contribute to pathology in various settings of disease.