Photo of Tiffany Horng,  PhD

Tiffany Horng, PhD

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-7526
Fax: (617) 432-5236


thorng@hsph.harvard.edu

Tiffany Horng, PhD

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Associate Professor, Genetics and Complex Diseases, Harvard T.H. Chan School Of Public Health

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our research focus is on the molecular basis of inflammation, in particular in its chronic state. Chronic inflammation contributes to common complex human diseases, including metabolic, cardiovascular, and neurodegenerative diseases and many cancers. In these settings, inflammation may be initially induced as an adaptive response to various forms of cellular and tissue stress (“para-inflammation”), but then becomes dysregulated for unknown reasons. We are interested in identifying the molecular signals that activate inflammation in non-infectious contexts and the inflammatory pathways that are engaged. We want to understand how these pathways intersect with other pathways for stress adaptation, how they become dysregulated, and how they contribute to pathology in various settings of disease.

Publications

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  • Horng T. mTOR trains heightened macrophage responses. Trends Immunol 2014; 36:1-2. PubMed
  • Covarrubias A, Byles V, Horng T. ROS sets the stage for macrophage differentiation. Cell Res 2013; 23:984-5. PubMed
  • Medzhitov R, Horng T. Transcriptional control of the inflammatory response. Nat Rev Immunol 2009; 9:692-703. PubMed
  • Hargreaves DC, Horng T, Medzhitov R. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 2009; 138:129-45. PubMed
  • Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol 2008; 9:361-8. PubMed
  • Horng T,Oberdoerffer S,Rao A. Gene regulation and signal transduction in the immune system. Genome Biol 2008; 9:315. PubMed
  • Horng T, Bezbradica JS, Medzhitov R. NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol 2007; 8:1345-52. PubMed
  • Horng T, Barton GM, Flavell RA, Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 2002; 420:329-33. PubMed