Photo of Timur Yusufzai,  PhD

Timur Yusufzai, PhD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 582-9214


timur_yusufzai@dfci.harvard.edu

Timur Yusufzai, PhD

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Assistant Professor, Biological Chemistry and Molecular Pharmacology, Harvard Medical School
  • Assistant Professor, Radiation Oncology, Harvard Medical School
  • Assistant Professor, Radiation Oncology, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Publications

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  • Manning BJ, Yusufzai T. The ATP-dependent Chromatin Remodeling Enzymes CHD6, CHD7, and CHD8 Exhibit Distinct Nucleosome Binding and Remodeling Activities. J Biol Chem 2017. PubMed
  • Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA, Ghobrial IM. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med 2017. PubMed
  • Burnham DR, Nijholt B, De Vlaminck I, Quan J, Yusufzai T, Dekker C. Annealing helicase HARP closes RPA-stabilized DNA bubbles non-processively. Nucleic Acids Res 2017. PubMed
  • Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature 2015; 518:258-62. PubMed
  • Liu JC, Ferreira CG, Yusufzai T. Human CHD2 is a chromatin assembly ATPase regulated by its chromo- and DNA-binding domains. J Biol Chem 2015; 290:25-34. PubMed
  • Quan J, Yusufzai T. The tumor suppressor chromodomain helicase DNA-binding protein 5 (CHD5) remodels nucleosomes by unwrapping. J Biol Chem 2014. PubMed
  • Quan J, Yusufzai T. HARP preferentially co-purifies with RPA bound to DNA-PK and blocks RPA phosphorylation. Epigenetics 2014; 9:693-7. PubMed
  • Quan J, Adelmant G, Marto JA, Look AT, Yusufzai T. The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1. PLoS ONE 2014; 9:e108066. PubMed
  • Yusufzai T, Kadonaga JT. Branching out with DNA helicases. Curr Opin Genet Dev 2011. PubMed
  • Yusufzai T, Kadonaga JT. Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif. Proc Natl Acad Sci U S A 2010; 107:20970-3. PubMed
  • Yusufzai T, Kong X, Yokomori K, Kadonaga JT. The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA. Genes Dev 2009; 23:2400-4. PubMed
  • Rattner BP, Yusufzai T, Kadonaga JT. HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. Mol Cell 2009; 34:620-6. PubMed
  • Yusufzai T, Kadonaga JT. HARP is an ATP-driven annealing helicase. Science 2008; 322:748-50. PubMed
  • Huang S, Li X, Yusufzai TM, Qiu Y, Felsenfeld G. USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier. Mol Cell Biol 2007; 27:7991-8002. PubMed
  • Magdinier F, Yusufzai TM, Felsenfeld G. Both CTCF-dependent and -independent insulators are found between the mouse T cell receptor alpha and Dad1 genes. J Biol Chem 2004; 279:25381-9. PubMed
  • Yusufzai TM, Felsenfeld G. The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element. Proc Natl Acad Sci U S A 2004; 101:8620-4. PubMed
  • Yusufzai TM, Tagami H, Nakatani Y, Felsenfeld G. CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Mol Cell 2004; 13:291-8. PubMed
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