Photo of Timur Yusufzai,  PhD

Timur Yusufzai, PhD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 582-9214


timur_yusufzai@dfci.harvard.edu

Timur Yusufzai, PhD

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Assistant Professor, Biological Chemistry and Molecular Pharmacology, Harvard Medical School
  • Assistant Professor, Radiation Oncology, Harvard Medical School
  • Assistant Professor, Radiation Oncology, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Publications

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  • Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD. Homologous-recombination-deficient tumours are dependent on Polæ…®-mediated repair. Nature 2015; 518:258-62. PubMed
  • Liu JC, Ferreira CG, Yusufzai T. Human CHD2 is a chromatin assembly ATPase regulated by its chromo- and DNA-binding domains. J Biol Chem 2015; 290:25-34. PubMed
  • Quan J, Yusufzai T. The Tumor Suppressor CHD5 Remodels Nucleosomes by Unwrapping. J Biol Chem 2014. PubMed
  • Quan J, Yusufzai T. HARP preferentially co-purifies with RPA bound to DNA-PK and blocks RPA phosphorylation. Epigenetics 2014. PubMed
  • Quan J, Adelmant G, Marto JA, Look AT, Yusufzai T. The Chromatin Remodeling Factor CHD5 Is a Transcriptional Repressor of WEE1. PLoS ONE 2014; 9:e108066. PubMed
  • Yusufzai T, Kadonaga JT. Branching out with DNA helicases. Curr Opin Genet Dev 2011. PubMed
  • Yusufzai T, Kadonaga JT. Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif. Proc Natl Acad Sci U S A 2010; 107:20970-3. PubMed
  • Yusufzai T, Kong X, Yokomori K, Kadonaga JT. The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA. Genes Dev 2009; 23:2400-4. PubMed
  • Rattner BP, Yusufzai T, Kadonaga JT. HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. Mol Cell 2009; 34:620-6. PubMed
  • Yusufzai T, Kadonaga JT. HARP is an ATP-driven annealing helicase. Science 2008; 322:748-50. PubMed
  • Huang S, Li X, Yusufzai TM, Qiu Y, Felsenfeld G. USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier. Mol Cell Biol 2007; 27:7991-8002. PubMed
  • Magdinier F, Yusufzai TM, Felsenfeld G. Both CTCF-dependent and -independent insulators are found between the mouse T cell receptor alpha and Dad1 genes. J Biol Chem 2004; 279:25381-9. PubMed
  • Yusufzai TM, Felsenfeld G. The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element. Proc Natl Acad Sci U S A 2004; 101:8620-4. PubMed
  • Yusufzai TM, Tagami H, Nakatani Y, Felsenfeld G. CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Mol Cell 2004; 13:291-8. PubMed
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