Photo of Tina Y. Poussaint,  MD

Tina Y. Poussaint, MD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-6450
Fax: (617) 730-0573


Tina.Poussaint@childrens.harvard.edu

Tina Y. Poussaint, MD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Director, PBTC Neuroimaging Center, Neuroradiology Education and Neurooncologic Imaging, Boston Children's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

1. Neuroimaging of pediatric brain and spine tumors including CT, MR, MR diffusion, MR perfusion and MR spectroscopy with attention to diagnosis, treatment, treatment effects, and followup. 2. Co-investigator: Natural history of plexiform neurofibromas using neuroimaging; U.S.Army grant. 3. PI, Neuroimaging Center, Children's Hospital Boston, Pediatric Brain Tumor Consortium

Publications

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  • Dombi E, Ardern-Holmes SL, Babovic-Vuksanovic D, Barker FG, Connor S, Evans DG, Fisher MJ, Goutagny S, Harris GJ, Jaramillo D, Karajannis MA, Korf BR, Mautner V, Plotkin SR, Poussaint TY, Robertson K, Shih CS, Widemann BC, . Recommendations for imaging tumor response in neurofibromatosis clinical trials. Neurology 2013; 81:S33-40. PubMed
  • Zukotynski KA, Fahey FH, Vajapeyam S, Ng SS, Kocak M, Gururangan S, Kun LE, Poussaint TY. Exploratory evaluation of MR permeability with 18F-FDG PET mapping in pediatric brain tumors: a report from the Pediatric Brain Tumor Consortium. J Nucl Med 2013; 54:1237-43. PubMed
  • Warren KE, Poussaint TY, Vezina G, Hargrave D, Packer RJ, Goldman S, Wen PY, Pollack IF, Zurakowski D, Kun LE, Prados MD, Rutkowski S, Kieran MW. Challenges With Defining Response to Antitumor Agents in Pediatric Neuro-Oncology: A Report From the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Group. Pediatr Blood Cancer 2013. PubMed
  • Gururangan S, Fangusaro J, Young Poussaint T, Onar-Thomas A, Gilbertson RJ, Vajapeyam S, Gajjar A, Goldman S, Friedman HS, Packer RJ, Boyett JM, Kun LE, McLendon R. Lack of efficacy of bevacizumab + irinotecan in cases of pediatric recurrent ependymoma--a Pediatric Brain Tumor Consortium study. 2012; 14:1404-12. PubMed
  • Prabhu SP, Ng S, Vajapeyam S, Kieran MW, Pollack IF, Geyer R, Haas-Kogan D, Boyett JM, Kun L, Poussaint TY. DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the Pediatric Brain Tumor Consortium. 2011; 27:11-8. PubMed
  • Fahey FH, Kinahan PE, Doot RK, Kocak M, Thurston H, Poussaint TY. Variability in PET quantitation within a multicenter consortium. Med Phys 2010; 37:3660-6. PubMed
  • Kieran MW,Supko JG,Wallace D,Fruscio R,Poussaint TY,Phillips P,Pollack I,Packer R,Boyett JM,Blaney S,Banerjee A,Geyer R,Friedman H,Goldman S,Kun LE,Macdonald T. Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors. Pediatr Blood Cancer 2008; 52:169-76. PubMed
  • Mulkern RV,Forbes P,Dewey K,Osganian S,Clark M,Wong S,Ramamurthy U,Kun L,Poussaint TY. Establishment and results of a magnetic resonance quality assurance program for the pediatric brain tumor consortium. Acad Radiol 2008; 15:1099-110. PubMed
  • Williams G, Fahey FH, Treves ST, Kocak M, Pollack IF, Boyett JM, Kun LE, Poussaint TY. Exploratory evaluation of two-dimensional and three-dimensional methods of FDG PET quantification in pediatric anaplastic astrocytoma: a report from the Pediatric Brain Tumor Consortium (PBTC). Eur J Nucl Med Mol Imaging 2008; 35:1651-8. PubMed
  • Haas-Kogan DA, Banerjee A, Kocak M, Prados MD, Geyer JR, Fouladi M, McKnight T, Poussaint TY, Broniscer A, Blaney SM, Boyett JM, Kun LE. Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma. Neuro-oncol 2008; 10:341-7. PubMed
  • MacDonald TJ, Stewart CF, Kocak M, Goldman S, Ellenbogen RG, Phillips P, Lafond D, Poussaint TY, Kieran MW, Boyett JM, Kun LE. Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012. J Clin Oncol 2008; 26:919-24. PubMed
  • Gururangan S, Turner CD, Stewart CF, O'Shaughnessy M, Kocak M, Poussaint TY, Phillips PC, Goldman S, Packer R, Pollack IF, Blaney SM, Karsten V, Gerson SL, Boyett JM, Friedman HS, Kun LE. Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study. Clin Cancer Res 2008; 14:1124-30. PubMed
  • Broniscer A, Gururangan S, MacDonald TJ, Goldman S, Packer RJ, Stewart CF, Wallace D, Danks MK, Friedman HS, Poussaint TY, Kun LE, Boyett JM, Gajjar A. Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report. Clin Cancer Res 2007; 13:6712-8. PubMed
  • Liu AK, Marcus KJ, Fischl B, Grant PE, Young Poussaint T, Rivkin MJ, Davis P, Tarbell NJ, Yock TI. Changes in cerebral cortex of children treated for medulloblastoma. Int J Radiat Oncol Biol Phys 2007; 68:992-8. PubMed
  • Poussaint TY, Phillips PC, Vajapeyam S, Fahey FH, Robertson RL, Osganian S, Ramamurthy U, Mulkern RV, Treves ST, Boyett JM, Kun LE. The Neuroimaging Center of the Pediatric Brain Tumor Consortium-collaborative neuroimaging in pediatric brain tumor research: a work in progress. AJNR Am J Neuroradiol 2007; 28:603-7. PubMed
  • Pollack IF, Jakacki RI, Blaney SM, Hancock ML, Kieran MW, Phillips P, Kun LE, Friedman H, Packer R, Banerjee A, Geyer JR, Goldman S, Poussaint TY, Krasin MJ, Wang Y, Hayes M, Murgo A, Weiner S, Boyett JM. Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report. Neuro-oncol 2007; 9:145-60. PubMed
  • Turner CD, Chi S, Marcus KJ, MacDonald T, Packer RJ, Poussaint TY, Vajapeyam S, Ullrich N, Goumnerova LC, Scott RM, Briody C, Chordas C, Zimmerman MA, Kieran MW. Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme. J Neurooncol 2006; 82:95-101. PubMed
  • Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, De Girolami U, Black PM, Tarbell NJ, Tzika AA. Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers. Int J Oncol 2007; 30:651-7. PubMed
  • Fouladi M, Blaney SM, Poussaint TY, Freeman BB, McLendon R, Fuller C, Adesina AM, Hancock ML, Danks MK, Stewart C, Boyett JM, Gajjar A. Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors: a pediatric brain tumor consortium study. Cancer 2006; 107:2291-7. PubMed
  • Gururangan S, Petros WP, Poussaint TY, Hancock ML, Phillips PC, Friedman HS, Bomgaars L, Blaney SM, Kun LE, Boyett JM. Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004). Clin Cancer Res 2006; 12:1540-6. PubMed
  • Baser ME, Poussaint TY. Age associated increase in the prevalence of chromosome 22q loss of heterozygosity in histological subsets of benign meningioma. J Med Genet 2005; 43:285-7. PubMed
  • Poussaint TY, Rodriguez D. Advanced neuroimaging of pediatric brain tumors: MR diffusion, MR perfusion, and MR spectroscopy. Neuroimaging Clin N Am 2006; 16:169-92, ix. PubMed
  • Anselm IM, Alkuraya FS, Salomons GS, Jakobs C, Fulton AB, Mazumdar M, Rivkin M, Frye R, Poussaint TY, Marsden D. X-linked creatine transporter defect: a report on two unrelated boys with a severe clinical phenotype. J Inherit Metab Dis 2006; 29:214-9. PubMed
  • Tzika AA, Astrakas LG, Zarifi MK, Zurakowski D, Poussaint TY, Goumnerova L, Tarbell NJ, Black PM. Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors. Cancer 2004; 100:1246-56. PubMed
  • Caruso PA, Poussaint TY, Tzika AA, Zurakowski D, Astrakas LG, Elias ER, Bay C, Irons MB. MRI and (1)H MRS findings in Smith-Lemli-Opitz syndrome. Neuroradiology 2004; 46:3-14. PubMed
  • Heath JA, Turner CD, Poussaint TY, Scott RM, Goumnerova L, Kieran MW. Chemotherapy for progressive low-grade gliomas in children older than ten years: the Dana-Farber experience. Pediatr Hematol Oncol 2003; 20:497-504. PubMed
  • Jaramillo D, Poussaint TY, Grottkau BE. Scoliosis: evidence-based diagnostic evaluation. Neuroimaging Clin N Am 2003; 13:335-41, xii. PubMed
  • Poussaint TY, Jaramillo D, Chang Y, Korf B. Interobserver reproducibility of volumetric MR imaging measurements of plexiform neurofibromas. AJR Am J Roentgenol 2003; 180:419-23. PubMed
  • Zarifi MK, Astrakas LG, Poussaint TY, Plessis Ad A, Zurakowski D, Tzika AA. Prediction of adverse outcome with cerebral lactate level and apparent diffusion coefficient in infants with perinatal asphyxia. Radiology 2002; 225:859-70. PubMed
  • Poussaint TY, Moeller KK. Imaging of pediatric head trauma. Neuroimaging Clin N Am 2002; 12:271-94, ix. PubMed
  • Faerber EN, Poussaint TY. Magnetic resonance of metabolic and degenerative diseases in children. Top Magn Reson Imaging 2002; 13:3-21. PubMed
  • Tzika AA, Zarifi MK, Goumnerova L, Astrakas LG, Zurakowski D, Young-Poussaint T, Anthony DC, Scott RM, Black PM. Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging. AJNR Am J Neuroradiol 2002; 23:322-33. PubMed
  • O'Tuama LA, Poussaint TY. Thallium-201 single-photon emission CT in recurrent squamous cell carcinoma of the head and neck. AJNR Am J Neuroradiol 2002; 23:174-5. PubMed
  • Poussaint TY. Magnetic resonance imaging of pediatric brain tumors: state of the art. Top Magn Reson Imaging 2001; 12:411-33. PubMed
  • Poussaint TY. Magnetic resonance imaging (MRI) is one of the most important imaging modalities in pediatric neuroradiology. Top Magn Reson Imaging 2001; 12:359. PubMed
  • Saad A, Folkerth R, Poussaint T, Smith E, Ligon K. Meningioangiomatosis associated with meningioma: a case report. Acta Cytol 2009; 53:93-7. PubMed
  • Young Poussaint T, Yousuf N, Barnes PD, Anthony DC, Zurakowski D, Scott RM, Tarbell NJ. Cervicomedullary astrocytomas of childhood: clinical and imaging follow-up. Pediatr Radiol 1999; 29:662-8. PubMed
  • O'Tuama LA, Poussaint TY, Anthony DC, Treves ST. Childhood brain tumor: neuroimaging correlated with disease outcome. Pediatr Neurol 1998; 19:259-62. PubMed
  • Poussaint TY, Kowal JR, Barnes PD, Zurakowski D, Anthony DC, Goumnerova L, Tarbell NJ. Tectal tumors of childhood: clinical and imaging follow-up. AJNR Am J Neuroradiol 1998; 19:977-83. PubMed
  • Medina LS, Zurakowski D, Strife KR, Robertson RL, Poussaint TY, Barnes PD. Efficacy of fast screening MR in children and adolescents with suspected intracranial tumors. AJNR Am J Neuroradiol 1998; 19:529-34. PubMed
  • Poussaint TY, Barnes PD, Nichols K, Anthony DC, Cohen L, Tarbell NJ, Goumnerova L. Diencephalic syndrome: clinical features and imaging findings. AJNR Am J Neuroradiol 1997; 18:1499-505. PubMed
  • Robertson RL, Burrows PE, Barnes PD, Robson CD, Poussaint TY, Scott RM. Angiographic changes after pial synangiosis in childhood moyamoya disease. AJNR Am J Neuroradiol 1997; 18:837-45. PubMed
  • Poussaint TY, Barnes PD, Anthony DC, Spack N, Scott RM, Tarbell NJ. Hemorrhagic pituitary adenomas of adolescence. AJNR Am J Neuroradiol 1996; 17:1907-12. PubMed
  • Levy HL, Lobbregt D, Barnes PD, Poussaint TY. Maternal phenylketonuria: magnetic resonance imaging of the brain in offspring. J Pediatr 1996; 128:770-5. PubMed
  • Poussaint TY, Siffert J, Barnes PD, Pomeroy SL, Goumnerova LC, Anthony DC, Sallan SE, Tarbell NJ. Hemorrhagic vasculopathy after treatment of central nervous system neoplasia in childhood: diagnosis and follow-up. AJNR Am J Neuroradiol 1995; 16:693-9. PubMed
  • Appignani BA, Jaramillo D, Barnes PD, Poussaint TY. Dysraphic myelodysplasias associated with urogenital and anorectal anomalies: prevalence and types seen with MR imaging. AJR Am J Roentgenol 1994; 163:1199-203. PubMed
  • Strand RD, Barnes PD, Poussaint TY, Estroff JA, Burrows PE. Cystic retrocerebellar malformations: unification of the Dandy-Walker complex and the Blake's pouch cyst. Pediatr Radiol 1993; 23:258-60. PubMed
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