Vicki R. Kelley, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital

Vicki R. Kelley, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Associate Professor, Medicine, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The focus of my laboratory is the molecular and cellular mechanisms of autoimmune disease and inflammation. We are identifying the events that lead to leukocytic accumulation in the tissues. Our ultimate goal is to identify therapeutic targets. These projects include understanding the immunoregulatory mechanisms. We are determining the impact of the co-stimulatory molecules that regulate T cell activation including the B7, ICOS and PD-1 pathways. We are studying the importance of the macrophage growth factor CSF-1 and its three forms, proteoglycan, glycoprotein, and membrane bound, in macrophage biology. This includes functional(recruitment, adherence, activation, phagocytosis) and gene expression studies, and impact on inflammation and autoimmune disease associated with lymphoproliferative disorders. We are identifying chemkine therapeutic targets in kidney inflammation and using gene transfer approaches to deliver chemokine receptor blockers.

Publications

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  • Menke J, Iwata Y, Rabacal WA, Basu R, Yeung YG, Humphreys BD, Wada T, Schwarting A, Stanley ER, Kelley VR. CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice. J Clin Invest 2009; 119:2330-42. PubMed
  • Menke J,Hsu MY,Byrne KT,Lucas JA,Rabacal WA,Croker BP,Zong XH,Stanley ER,Kelley VR. Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice. J Immunol 2008; 181:7367-79. PubMed
  • Lucas JA,Menke J,Rabacal WA,Schoen FJ,Sharpe AH,Kelley VR. Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. J Immunol 2008; 181:2513-21. PubMed
  • Menke J,Zeller GC,Kikawada E,Means TK,Huang XR,Lan HY,Lu B,Farber J,Luster AD,Kelley VR. CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease. J Am Soc Nephrol 2008; 19:1177-89. PubMed
  • Jang MH, Herber DM, Jiang X, Nandi S, Dai XM, Zeller G, Stanley ER, Kelley VR. Distinct in vivo roles of colony-stimulating factor-1 isoforms in renal inflammation. J Immunol 2006; 177:4055-63. PubMed
  • Lenda DM, Stanley ER, Kelley VR. Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Fas(lpr) mice. J Immunol 2004; 173:4744-54. PubMed
  • Kikawada E, Lenda DM, Kelley VR. IL-12 deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. J Immunol 2003; 170:3915-25. PubMed
  • Shinozaki M, Hirahashi J, Lebedeva T, Liew FY, Salant DJ, Maron R, Kelley VR. IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis. J Clin Invest 2002; 109:951-60. PubMed
  • Kinoshita K, Tesch G, Schwarting A, Maron R, Sharpe AH, Kelley VR. Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice. J Immunol 2000; 164:6046-56. PubMed