Photo of Wei Zhang,  PhD

Wei Zhang, PhD

University Of Massachusetts - Boston

University Of Massachusetts - Boston
Phone: (617) 287-6147
Fax: (617) 287-6030


wei2.zhang@umb.edu

Wei Zhang, PhD

University Of Massachusetts - Boston

EDUCATIONAL TITLES

  • Professor, Chemistry, University Of Massachusetts - Boston
  • Director of the Center for Green Chemistry, Department of Chemistry, University Of Massachusetts - Boston

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our research lab has been focused on the develop new synthetic technologies for medicinal chemistry and green chemistry applications. A wide range of new drug-like molecules and natural product analogs have been prepared for drug discovery programs including lead generation and lead optimizations.

Publications

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  • Zhang Z, Kwiatkowski N, Zeng H, Lim SM, Gray NS, Zhang W, Yang PL. Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy. Mol Biosyst 2012; 8:2523-6. PubMed
  • Zhou J, Mao HF, Wang L, Zou JP, Zhang W. Lithium perchlorate-nitromethane-promoted alkylation of anilines with arylmethanols. Mol. Divers. 2011; 15:849-55. PubMed
  • Zhang W. Fluorous Organocatalysis. 2011. PubMed
  • Pan XQ, Wang L, Zou JP, Zhang W. Manganese(III)-mediated phosphinoyl radical reactions for stereoselective synthesis of phosphinoylated tetrahydronaphthalenes. Chem Commun (Camb) 2011; 47:7875-7. PubMed
  • Piqani B, Zhang W. Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications. Beilstein J Org Chem 2011; 7:1294-8. PubMed
  • Dolle RE, Bourdonnec BL, Worm K, Morales GA, Thomas CJ, Zhang W. Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2009. J Comb Chem 2010; 12:765-806. PubMed
  • Zhu X, Zhang W, Chen X, Wu H, Duan Y, Xu Z. Generation of high rapamycin producing strain via rational metabolic pathway-based mutagenesis and further titer improvement with fed-batch bioprocess optimization. Biotechnol Bioeng 2010; 107:506-15. PubMed
  • Liao W, Chen H, Feng Y, Mantini D, Gentili C, Pan Z, Ding J, Duan X, Qiu C, Lui S, Gong Q, Zhang W. Selective aberrant functional connectivity of resting state networks in social anxiety disorder. Neuroimage 2010; 52:1549-58. PubMed
  • Zhang W, Shi Y, Chen Y, Yu S, Hao J, Luo J, Sha X, Fang X. Enhanced antitumor efficacy by Paclitaxel-loaded Pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance. 2010; 75:341-53. PubMed
  • Song G, Liu H, Zhang W, Geng M, Li Y. Synthesis and biological evaluation of cytotoxic activity of novel anthracene l-rhamnopyranosides. Bioorg Med Chem 2010; 18:5183-93. PubMed
  • Meng J, Zhang W, Cao CX, Fan LY, Wu J, Wang QL. Moving affinity boundary electrophoresis and its selective isolation of histidine in urine. Analyst 2010; 135:1592-9. PubMed
  • Mao XG, Guo G, Wang P, Zhang X, Xue XY, Zhang W, Fei Z, Jiang XF, Yan M. Maintenance of Critical Properties of Brain Tumor Stem-like Cells After Cryopreservation. Cell Mol Neurobiol 2010; 30:775-86. PubMed
  • Rogers B, Zhang W, Narayana S, Lancaster JL, Robin DA, Fox PT. Force sensing system for automated assessment of motor performance during fMRI. J Neurosci Methods 2010; 190:92-4. PubMed
  • Luan X, Hong D, Zhang W, Wang Z, Yuan Y. A novel heterozygous deletion-insertion mutation (2695-2712 del/GTTTGT ins) in exon 18 of the filamin C gene causes filaminopathy in a large Chinese family. 2010; 20:390-396. PubMed
  • Hong D, Luan X, Chen B, Zheng R, Zhang W, Wang Z, Yuan Y. Both hypokalaemic and normokalaemic periodic paralysis in different members of a single family with novel R1129Q mutation in SCN4A gene. J Neurol Neurosurg Psychiatry 2010; 81:703-4. PubMed
  • Lou Z, Zhang W, Yu ED, Liu LJ, Wang HT, Xu HL, He HY, Meng RG, Fu CG. [Effect of colonoscopy combined with placement of metallic clips on selecting colonic surgery incision.] 2010; 13:406-8. PubMed
  • Liu BL, Cheng JX, Zhang W, Zhang X, Wang R, Lin H, Huo JL, Cheng H. Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebrospinal fluid predicts prognosis of malignant gliomas. 2010; 12:540-8. PubMed
  • Zhang W, Dang XQ, Bo T. [Cutaneous T-cell lymphomas complicated by renal injury: a case report.] Zhongguo Dang Dai Er Ke Za Zhi 2010; 12:498-9. PubMed
  • Hu A, Zhang W, Wang Z. Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway. Proc Natl Acad Sci U S A 2010; 107:10262-7. PubMed
  • Li Z, Zhang W, Li ZB, Li JR. Mechanism in favorable prognosis of pediatric condylar fractures managed by closed procedures: an experimental study in growing rats. Dent Traumatol 2010; 26:228-35. PubMed
  • Li H, Zhang W, Sheng M, Li W, Liu Y, Liu S, Qi C. [Cloning, expression, purification of spinach carboxyl-terminal processing protease of D1 protein with hydrolysis activity and preparation of polyclonal antibody] Sheng Wu Gong Cheng Xue Bao 2010; 26:495-502. PubMed
  • Xu J, Yun X, Jiang J, Wei Y, Wu Y, Zhang W, Liu Y, Wang W, Wen Y, Gu J. Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage. Hepatology 2010; 52:142-154. PubMed
  • Zhang W, Dolan ME. Impact of the 1000 genomes project on the next wave of pharmacogenomic discovery. Pharmacogenomics 2010; 11:249-56. PubMed
  • Xiong W, Ren ZG, Qiu SJ, Sun HC, Wang L, Liu BB, Li QS, Zhang W, Zhu XD, Liu L, Wang WQ, Tang ZY. Residual hepatocellular carcinoma after oxaliplatin treatment has increased metastatic potential in a nude mouse model and is attenuated by Songyou Yin. BMC Cancer 2010; 10:219. PubMed
  • Li Y,Pan S,Zhang W,Du Z. Novel thermo-sensitive core-shell nanoparticles for targeted paclitaxel delivery. Nanotechnology 2009; 20:65104. PubMed
  • Zhang, W.. Fluorous Linker-Facilitated Chemical Synthesis Chem. Rev. 2009; 109:749-795.
  • Zhang W, Cai C. New chemical and biological applications of fluorous technologies. Chem Commun (Camb) 2008. PubMed
  • Zhang, W.. Fluorous Organocatalysis Top. in Curr. Chem 2012; 308: 175-190.
  • Lu, Q.; Song, G.; Jasinski, J. P.; Keeley, A. C.; Zhang, W.. One-pot double [3+2] Cycloaddition for Diastereoselective Synthesis of Tetracyclic Pyrrolidine Compounds Green Chem. 2012; 14:3010-3012.
  • Yi, W.-B.; Huang, X.; Zhang, Z.; Zhu, D.-Z.; Cai, C.; Zhang, W. . Recyclable Fluorous Cinchona Alkaloid Ester as an Organocatalyst for Asymmetric Fluorination of -Ketoesters Beilstein J. Org. Chem. 2012; 8:1233–1240.
  • Yi, W.-B.; Huang, X.; Cai, C.; Zhang, W. . One-Pot Fluorination Followed by Michael Addition or Robinson Annulation for Preparation of -Fluorinated Carbonyl Compounds Green Chem. 2012; 14:3185-3189.
  • Zhu, J.; Larman, H. B.; Gao, G.; Somwar, R.; Zhang, Z.; Laserson, U; Alberto Ciccia, A.; Pavlova, N.; Church, G.; Zhang, W.; Kesari, S.; Elledge, S. J. . Protein interaction discovery using parallel analysis of translated ORFs (PLato) Nat Biotechnol 2013; 41:331-334.
  • Wang , L.; Wang , J.-W.; Cui, A.-J.; Cai, X.-X.; Wan, Y.; Chen, Q.; He, M.-Y.; Zhang, W. . Regioselective 2,6-Dihalogenation of BODIPYs in HFIP and Preparation of Novel Meso-Alkyl Polymeric BODIPY Dye RSC Adv. 2013; 3:9219-9222.
  • Zhang, W.. Laboratory profile of the Green Organic and Medicinal Chemistry at the University of Massachusetts Boston Green Procc. Synth. 2013; 1:291-293.
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