Photo of Wei Zhang,  PhD

Wei Zhang, PhD

University Of Massachusetts - Boston

University Of Massachusetts - Boston
Phone: (617) 287-6147
Fax: (617) 287-6030


wei2.zhang@umb.edu

Wei Zhang, PhD

University Of Massachusetts - Boston

EDUCATIONAL TITLES

  • Professor, Chemistry, University Of Massachusetts - Boston
  • Director of the Center for Green Chemistry, Department of Chemistry, University Of Massachusetts - Boston

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our research lab has been focused on the develop new synthetic technologies for medicinal chemistry and green chemistry applications. A wide range of new drug-like molecules and natural product analogs have been prepared for drug discovery programs including lead generation and lead optimizations.

Publications

Powered by Harvard Catalyst
  • Urick, A.; Hawk, L.; Cassel, M.; Mishra, N.; Adhikari, N.; Liu, S.; Zhang, W.; Hall, J.; Pomerantz, W. . Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules ACS Chem. Biol 2015; 10:2246-2256.
  • McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE. Biased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem 2014. PubMed
  • Vetter, M. L. Zhang, Z.; Liu, S,; Wang, J.; Cho, H.; Zhang, J.; Zhang, W.; Gray, N. S.; Yang, P. L. . Fluorescent Visualization of Src Using BODIPY-Dasatinib ChemBioChem 2014; 15:1317-1324.
  • Zhang Z, Kwiatkowski N, Zeng H, Lim SM, Gray NS, Zhang W, Yang PL. Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy. Mol Biosyst 2012; 8:2523-6. PubMed
  • Zhang W. Fluorous organocatalysis. 2011. PubMed
  • Zhou J, Mao HF, Wang L, Zou JP, Zhang W. Lithium perchlorate-nitromethane-promoted alkylation of anilines with arylmethanols. Mol. Divers. 2011; 15:849-55. PubMed
  • Pan XQ, Wang L, Zou JP, Zhang W. Manganese(III)-mediated phosphinoyl radical reactions for stereoselective synthesis of phosphinoylated tetrahydronaphthalenes. Chem Commun (Camb) 2011; 47:7875-7. PubMed
  • Piqani B, Zhang W. Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications. Beilstein J Org Chem 2011; 7:1294-8. PubMed
  • Dolle RE, Bourdonnec BL, Worm K, Morales GA, Thomas CJ, Zhang W. Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2009. J Comb Chem 2010; 12:765-806. PubMed
  • Zhang, W.. Fluorous Linker-Facilitated Chemical Synthesis Chem. Rev. 2009; 109:749-795.
  • Zhang W, Cai C. New chemical and biological applications of fluorous technologies. Chem Commun (Camb) 2008. PubMed
  • Lu, Q.; Song, G.; Jasinski, J. P.; Keeley, A. C.; Zhang, W.. One-pot double [3+2] Cycloaddition for Diastereoselective Synthesis of Tetracyclic Pyrrolidine Compounds Green Chem. 2012; 14:3010-3012.
  • Zhang, W.. Fluorous Organocatalysis Top. in Curr. Chem 2012; 308: 175-190.
  • Zhu, J.; Larman, H. B.; Gao, G.; Somwar, R.; Zhang, Z.; Laserson, U; Alberto Ciccia, A.; Pavlova, N.; Church, G.; Zhang, W.; Kesari, S.; Elledge, S. J. . Protein interaction discovery using parallel analysis of translated ORFs (PLato) Nat Biotechnol 2013; 41:331-334.
  • Yi, W.-B.; Huang, X.; Cai, C.; Zhang, W. . One-Pot Fluorination Followed by Michael Addition or Robinson Annulation for Preparation of -Fluorinated Carbonyl Compounds Green Chem. 2012; 14:3185-3189.
  • Wang , L.; Wang , J.-W.; Cui, A.-J.; Cai, X.-X.; Wan, Y.; Chen, Q.; He, M.-Y.; Zhang, W. . Regioselective 2,6-Dihalogenation of BODIPYs in HFIP and Preparation of Novel Meso-Alkyl Polymeric BODIPY Dye RSC Adv. 2013; 3:9219-9222.
  • Zhang, W.. Laboratory profile of the Green Organic and Medicinal Chemistry at the University of Massachusetts Boston Green Procc. Synth. 2013; 1:291-293.
  • Yi, W.-B.; Huang, X.; Zhang, Z.; Zhu, D.-Z.; Cai, C.; Zhang, W. . Recyclable Fluorous Cinchona Alkaloid Ester as an Organocatalyst for Asymmetric Fluorination of -Ketoesters Beilstein J. Org. Chem. 2012; 8:1233–1240.
Hide