Photo of Xihong Lin,  PhD

Xihong Lin, PhD

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-2914
Fax: (617) 432-5619


xlin@hsph.harvard.edu

Xihong Lin, PhD

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Henry Pickering Walcott Professor of Biostatistics, Biostatistics, Harvard T.H. Chan School Of Public Health

DF/HCC PROGRAM AFFILIATION

DF/HCC ASSOCIATIONS

  • Member, Center Scientific Council

Research Abstract

My research interests lie in developing and applying statistical and computational methods to analysis of correlated data and high throughput omics data. I am interested in observational studies such as case-control and longitudinal and cohort studies. My current interests center around analysis of high-dimensional genomic and omics data especially in population-based studies, such as genome-wide association studies and sequencing data, epigenetics, biomaker discovery, and genes and environment, especially in cancer epidemiology and cancer prevention and intervention studies.

Publications

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  • Seow WJ, Pan WC, Kile ML, Tong L, Baccarelli AA, Quamruzzaman Q, Rahman M, Mostofa G, Rakibuz-Zaman M, Kibriya M, Ahsan H, Lin X, Christiani DC. A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh. Cancer 2015. PubMed
  • Wang Z, Choi S, Lee J, Huang YT, Chen F, Zhao Y, Lin X, Neuberg D, Kim J, Christiani DC. Mitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival. Cancer Inform 2015; 14:1-9. PubMed
  • Cao Y, Lindström S, Schumacher F, Stevens VL, Albanes D, Berndt S, Boeing H, Bueno-de-Mesquita HB, Canzian F, Chamosa S, Chanock SJ, Diver WR, Gapstur SM, Gaziano JM, Giovannucci EL, Haiman CA, Henderson B, Johansson M, Le Marchand L, Palli D, Rosner B, Siddiq A, Stampfer M, Stram DO, Tamimi R, Travis RC, Trichopoulos D, Willett WC, Yeager M, Kraft P, Hsing AW, Pollak M, Lin X, Ma J. Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival. Journal of the National Cancer Institute 2014; 106:dju085. PubMed
  • Wong JY, De Vivo I, Lin X, Grashow R, Cavallari J, Christiani DC. The association between global DNA methylation and telomere length in a longitudinal study of boilermakers. Genet Epidemiol 2014; 38:254-64. PubMed
  • Wang C, Zhan X, Bragg-Gresham J, Kang HM, Stambolian D, Chew EY, Branham KE, Heckenlively J, , Fulton R, Wilson RK, Mardis ER, Lin X, Swaroop A, Zöllner S, Abecasis GR. Ancestry estimation and control of population stratification for sequence-based association studies. Nat Genet 2014; 46:409-15. PubMed
  • Huang YT, Vanderweele TJ, Lin X. JOINT ANALYSIS OF SNP AND GENE EXPRESSION DATA IN GENETIC ASSOCIATION STUDIES OF COMPLEX DISEASES. Ann Appl Stat 2014; 8:352-376. PubMed
  • Seow WJ, Kile ML, Baccarelli AA, Pan WC, Byun HM, Mostofa G, Quamruzzaman Q, Rahman M, Lin X, Christiani DC. Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: A case-control follow-up study. Environ Mol Mutagen 2014. PubMed
  • Wong JY, De Vivo I, Lin X, Fang SC, Christiani DC. The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study. PLoS ONE 2014; 9:e87348. PubMed
  • Wong JY, De Vivo I, Lin X, Christiani DC. Cumulative PM(2.5) exposure and telomere length in workers exposed to welding fumes. J. Toxicol. Environ. Health Part A 2014; 77:441-55. PubMed
  • Wang X, Lee S, Zhu X, Redline S, Lin X. GEE-based SNP set association test for continuous and discrete traits in family-based association studies. Genet Epidemiol 2013; 37:778-86. PubMed
  • Qian ZR, Ter-Minassian M, Chan JA, Imamura Y, Hooshmand SM, Kuchiba A, Morikawa T, Brais LK, Daskalova A, Heafield R, Lin X, Christiani DC, Fuchs CS, Ogino S, Kulke MH. Prognostic significance of MTOR pathway component expression in neuroendocrine tumors. J Clin Oncol 2013; 31:3418-25. PubMed
  • Ionita-Laza I, Lee S, Makarov V, Buxbaum JD, Lin X. Sequence kernel association tests for the combined effect of rare and common variants. Am J Hum Genet 2013; 92:841-53. PubMed
  • Dicker L, Lin X. Parallelism, uniqueness, and large-sample asymptotics for the Dantzig selector. 2013; 41:23-35. PubMed
  • Barnett IJ, Lee S, Lin X. Detecting rare variant effects using extreme phenotype sampling in sequencing association studies. Genet Epidemiol 2013; 37:142-51. PubMed
  • Ter-Minassian M, Chan JA, Hooshmand SM, Brais LK, Daskalova A, Heafield R, Buchanan L, Qian ZR, Fuchs CS, Lin X, Christiani DC, Kulke MH. Clinical presentation, recurrence, and survival in patients with neuroendocrine tumors: results from a prospective institutional database. Endocr. Relat. Cancer 2013; 20:187-96. PubMed
  • Liao SY, Lin X, Christiani DC. Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study. Environ Health 2014; 12:101. PubMed
  • Huang YT, Lin X. Gene set analysis using variance component tests. BMC Bioinformatics 2013; 14:210. PubMed
  • Cai T, Lin X, Carroll RJ. Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics 2012; 13:776-90. PubMed
  • Lee S, Wu MC, Lin X. Optimal tests for rare variant effects in sequencing association studies. Biostatistics 2012; 13:762-75. PubMed
  • Lee S, Emond MJ, Bamshad MJ, Barnes KC, Rieder MJ, Nickerson DA, , Christiani DC, Wurfel MM, Lin X. Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies. Am J Hum Genet 2012; 91:224-37. PubMed
  • Wang L, Rotnitzky A, Lin X, Millikan RE, Thall PF. Evaluation of Viable Dynamic Treatment Regimes in a Sequentially Randomized Trial of Advanced Prostate Cancer. Journal of the American Statistical Association 2012; 107:493-508. PubMed
  • Zhao Y, Chen F, Zhai R, Lin X, Diao N, Christiani DC. Association Test Based on SNP Set: Logistic Kernel Machine Based Test vs. Principal Component Analysis. PLoS ONE 2012; 7:e44978. PubMed
  • Cai T, Tonini G, Lin X. Kernel Machine Approach to Testing the Significance of Multiple Genetic Markers for Risk Prediction. Biometrics 2011. PubMed
  • Dicker L, Lin X, Ivanov AR. Increased power for the analysis of label-free LC-MS/MS proteomic data by combining spectral counts and peptide peak attributes. Mol Cell Proteomics 2010; 9:2704-18. PubMed
  • Paulus JK, Zhou W, Kraft P, Johnson BE, Lin X, Christiani DC. Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women. Lung Cancer 2010. PubMed
  • Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. A Large Scale Genetic Association Study of Esophageal Adenocarcinoma Risk. Carcinogenesis 2010; 31:1259-63. PubMed
  • Wu MC, Kraft P, Epstein MP, Taylor DM, Chanock SJ, Hunter DJ, Lin X. Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet 2010; 86:929-42. PubMed
  • Zhai R, Chen F, Liu G, Su L, Kulke MH, Asomaning K, Lin X, Heist RS, Nishioka NS, Sheu CC, Wain JC, Christiani DC. Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma. J Clin Oncol 2010; 28:2445-51. PubMed
  • Yu Z, Lin X. SEMIPARAMETRIC REGRESSION WITH TIME-DEPENDENT COEFFICIENTS FOR FAILURE TIME DATA ANALYSIS. Stat Sin 2010; 20:853-869. PubMed
  • Paulus JK, Asomaning K, Kraft P, Johnson BE, Lin X, Christiani DC. Parity and risk of lung cancer in women. Am J Epidemiol 2010; 171:557-63. PubMed
  • Li Y,Lin X,Muller P. Bayesian Inference in Semiparametric Mixed Models for Longitudinal Data. Biometrics 2010; 66:70-8. PubMed
  • Naylor MG, Lin X, Weiss ST, Raby BA, Lange C. Using canonical correlation analysis to discover genetic regulatory variants. PLoS ONE 2010; 5:e10395. PubMed
  • Wu MC, Lin X. Prior biological knowledge-based approaches for the analysis of genome-wide expression profiles using gene sets and pathways. 2010; 18:577-93. PubMed
  • Epstein MP, Hunter JE, Allen EG, Sherman SL, Lin X, Boehnke M. A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes. 2010; 1:181-198. PubMed
  • Pan W,Zeng D,Lin X. Estimation in Semiparametric Transition Measurement Error Models for Longitudinal Data. Biometrics 2009; 65:728-36. PubMed
  • Huang YT,Heist RS,Chirieac LR,Lin X,Skaug V,Zienolddiny S,Haugen A,Wu MC,Wang Z,Su L,Asomaning K,Christiani DC. Genome-wide analysis of survival in early-stage non-small-cell lung cancer. J Clin Oncol 2009; 27:2660-7. PubMed
  • Little RJ,Long Q,Lin X. A Comparison of Methods for Estimating the Causal Effect of a Treatment in Randomized Clinical Trials Subject to Noncompliance. Biometrics 2009; 65:640-9. PubMed
  • Wu MC,Zhang L,Wang Z,Christiani DC,Lin X. Sparse linear discriminant analysis for simultaneous testing for the significance of a gene set/pathway and gene selection. Bioinformatics 2009; 25:1145-51. PubMed
  • Zhai R,Liu G,Asomaning K,Su L,Kulke MH,Heist RS,Nishioka NS,Lynch TJ,Wain JC,Lin X,Christiani DC. Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk. Carcinogenesis 2008; 29:2330-4. PubMed
  • Li Y,Prentice RL,Lin X. Semiparametric Maximum Likelihood Estimation in Normal Transformation Models for Bivariate Survival Data. Biometrika 2008; 95:947-960. PubMed
  • Ye W, Lin X, Taylor JM. Semiparametric Modeling of Longitudinal Measurements and Time-to-Event Data-A Two-Stage Regression Calibration Approach. Biometrics 2008; 64:1238-46. PubMed
  • Ter-Minassian M,Zhai R,Asomaning K,Su L,Zhou W,Liu G,Heist RS,Lynch TJ,Wain JC,Lin X,De Vivo I,Christiani DC. Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Carcinogenesis 2008; 29:2147-52. PubMed
  • Nan B, Lin X. Analysis of case-control age-at-onset data using a modified case-cohort method. Biom J 2008; 50:311-20. PubMed
  • Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L, Lin X, Greenfield TK, Litwin MS, Saigal CS, Mahadevan A, Klein E, Kibel A, Pisters LL, Kuban D, Kaplan I, Wood D, Ciezki J, Shah N, Wei JT. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med 2008; 358:1250-61. PubMed
  • Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, Asomaning K, Lynch TJ, Wain JC, Christiani DC. VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. J Clin Oncol 2008; 26:856-62. PubMed
  • Kwee LC,Liu D,Lin X,Ghosh D,Epstein MP. A powerful and flexible multilocus association test for quantitative traits. Am J Hum Genet 2008; 82:386-97. PubMed
  • Zhai R, Liu G, Zhou W, Su L, Heist RS, Lynch TJ, Wain JC, Asomaning K, Lin X, Christiani DC. Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. Clin Cancer Res 2008; 14:612-7. PubMed
  • Harezlak J,Wu MC,Wang M,Schwartzman A,Christiani DC,Lin X. Biomarker discovery for arsenic exposure using functional data. Analysis and feature learning of mass spectrometry proteomic data. J Proteome Res 2008; 7:217-24. PubMed
  • Liu D,Ghosh D,Lin X. Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models. BMC Bioinformatics 2008; 9:292. PubMed
  • Lin X. Estimation using penalized quasilikelihood and quasi-pseudo-likelihood in Poisson mixed models. Lifetime Data Analysis 2007; 13:533-44. PubMed
  • Liu D, Lin X, Ghosh D. Semiparametric regression of multidimensional genetic pathway data: least-squares kernel machines and linear mixed models. Biometrics 2007; 63:1079-88. PubMed
  • Schipper M, Taylor JM, Lin X. Bayesian generalized monotonic functional mixed models for the effects of radiation dose histograms on normal tissue complications. Stat Med 2007; 26:4643-56. PubMed
  • Harezlak J,Wang M,Christiani D,Lin X. Quantitative quality-assessment techniques to compare fractionation and depletion methods in SELDI-TOF mass spectrometry experiments. Bioinformatics 2007; 23:2441-8. PubMed
  • Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Janne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007; 448:807-10. PubMed
  • Grewal J, Sowers MR, Randolph JF, Harlow SD, Lin X. Low bone mineral density in the early menopausal transition: role for ovulatory function. J Clin Endocrinol Metab 2006; 91:3780-5. PubMed
  • Diez Roux AV, Auchincloss AH, Astor B, Barr RG, Cushman M, Dvonch T, Jacobs DR, Kaufman J, Lin X, Samson P. Recent exposure to particulate matter and C-reactive protein concentration in the multi-ethnic study of atherosclerosis. Am J Epidemiol 2006; 164:437-48. PubMed
  • Li Y, Lin X. Semiparametric normal transformation models for spatially correlated survival data Journal of the American Statistical Association 2006; 101:591-603.
  • Cabana MD, Slish KK, Evans D, Mellins RB, Brown RW, Lin X, Kaciroti N, Clark NM. Impact of physician asthma care education on patient outcomes. Pediatrics 2006; 117:2149-57. PubMed
  • Wu M, Lin X. Prior biological knowledge based approaches for the analysis of genome-wide expression profiles using gene sets and pathways 2009.
  • Ye W, Lin X. A penalized likelihood approach to joint modeling of longitudinal measurements and time to event data 2008.
  • Wang L, Rotnitzky A, Lin X. Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations JASA 2010; 105:1135-1146.
  • Yu Z, Lin X. Nonparametric regression using local kernel estimating equations for correlated failure time data Biometrika 2008; 95:123-137.
  • Long Q, Little RJ, Lin X. Causal Inference in Hybrid Intervention Trials Involving Treatment Choice JASA 2008; 103:474-484.
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