Photo of Xin Yuan,  MD, DSc

Xin Yuan, MD, DSc

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 735-2066


xyuan@bidmc.harvard.edu

Xin Yuan, MD, DSc

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Assistant Professor, Medicine, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

The major focus of the lab is on the molecular basis of cancer development and progression. One of the focus areas is the molecular and functional contribution of the SOX9 developmental factor in prostate and breast cancers. We have discovered that SOX9 is an important convergence node of multiple signal pathways that are critical for the development and oncogenesis. These signal pathways include androgen receptor, WNT, and ERG signals. SOX9 critically mediating these oncogenic signals and enhances tumor formation, invasion, treatment resistance, and angiogenesis. The SOX9 signal pathway represents novel therapeutic targets for intervention and biomarkers for disease progression.

Publications

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  • Ma F, Ye H, He HH, Gerrin SJ, Chen S, Tanenbaum BA, Cai C, Sowalsky AG, He L, Wang H, Balk SP, Yuan X. SOX9 drives WNT pathway activation in prostate cancer. J Clin Invest 2016. PubMed
  • Wang H, He L, Ma F, Regan MM, Balk SP, Richardson AL, Yuan X. SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/β-catenin activation in breast cancer. J Biol Chem 2013; 288:6478-87. PubMed
  • Cai C, Wang H, He HH, Chen S, He L, Ma F, Mucci L, Wang Q, Fiore C, Sowalsky AG, Loda M, Liu XS, Brown M, Balk SP, Yuan X. ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer. J Clin Invest 2013; 123:1109-22. PubMed
  • Wang H, Leav I, Ibaragi S, Wegner M, Hu GF, Lu ML, Balk SP, Yuan X. SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion. Cancer Res 2008; 68:1625-30. PubMed
  • Wang H, McKnight NC, Zhang T, Lu ML, Balk SP, Yuan X. SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells. Cancer Res 2007; 67:528-36. PubMed