The major focus of the lab is on the molecular basis of cancer development and progression. One of the focus areas is the molecular and functional contribution of the SOX9 developmental factor in prostate and breast cancers. We have discovered that SOX9 is an important convergence node of multiple signal pathways that are critical for the development and oncogenesis. These signal pathways include androgen receptor, WNT, and ERG signals. SOX9 critically mediating these oncogenic signals and enhances tumor formation, invasion, treatment resistance, and angiogenesis. The SOX9 signal pathway represents novel therapeutic targets for intervention and biomarkers for disease progression.