Photo of Yolonda L. Colson,  MD, PhD

Yolonda L. Colson, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-6648
Fax: (617) 730-2863

Yolonda L. Colson, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Professor, Surgery, Harvard Medical School
  • Assistant Professor, Thoracic Surgery, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Major Research Interests: Transplantation Immunology and Tolerance Induction, Bone Marrow Chimerism, Hematopoietic Stem Cell Biology, Innate and Adaptive Immunity, and Lung Cancer.

Less than half of all lung transplant patients survive more than 5 years as a result of opportunistic infections, chronic rejection, end-organ toxicity or secondary malignancy. Therefore, our major research efforts are focused on approaches to re-educate the recipient immune system for the induction of permanent donor-specific tolerance while maintaining recipient immunocompetence. Engraftment of both donor and recipient hematopoietic stem cells (SC) results in mixed bone marrow (BM) chimerism, induces donor-specific tolerance for allogeneic and xenogeneic solid organ grafts, preserves recipient immunocompetence, and is not associated with chronic rejection. However, the morbidity and mortality associated with graft vs. host disease (GVHD), ablative recipient conditioning, and failure of SC engraftment has prevented the direct clinical application of BM-induced tolerance. We have characterized a rare BM-derived cell population known as the facilitating cell (FC), that is sufficient to permit engraftment of highly purified murine SC in completely MHC-disparate recipients and induce transplantation tolerance without evidence of GVHD. Our laboratory has identified a novel member of the T cell receptor beta (TCRbeta) heterodimer family on the FC, that is responsible for the unique properties of allogeneic SC facilitation and tolerance induction in vivo. Isolation, purification, and characterization of the FCp33/TCRbeta/CD3epsilon receptor and the signaling pathways utilized for tolerance induction form a major research focus of the current NIH funded laboratory.

Other active research interests are involved in the study of the role of innate immunity in chronic rejection of human lung allografts and local therapies for the treatment of lung cancer.

Publications

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  • Lei H, Hofferberth SC, Liu R, Colby A, Tevis KM, Catalano P, Grinstaff MW, Colson YL. Paclitaxel-loaded expansile nanoparticles enhance chemotherapeutic drug delivery in mesothelioma 3-dimensional multicellular spheroids. J Thorac Cardiovasc Surg 2015. PubMed
  • Mohiuddin K, Haneuse S, Sofer T, Gill R, Jaklitsch MT, Colson YL, Wee J, Bueno R, Mentzer SJ, Sugarbaker DJ, Swanson SJ. Relationship between margin distance and local recurrence among patients undergoing wedge resection for small (竕、2 cm) non-small cell lung cancer. J Thorac Cardiovasc Surg 2014; 147:1169-75; discussion 1175-7. PubMed
  • Charoen KM, Fallica B, Colson YL, Zaman MH, Grinstaff MW. Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations. Biomaterials 2014; 35:2264-71. PubMed
  • Coroller TP, Mak RH, Lewis JH, Baldini EH, Chen AB, Colson YL, Hacker FL, Hermann G, Kozono D, Mannarino E, Molodowitch C, Wee JO, Sher DJ, Killoran JH. Low incidence of chest wall pain with a risk-adapted lung stereotactic body radiation therapy approach using three or five fractions based on chest wall dosimetry. PLoS ONE 2014; 9:e94859. PubMed
  • Gaur P, Dunne R, Colson YL, Gill RR. Bronchopleural fistula and the role of contemporary imaging. J Thorac Cardiovasc Surg 2013. PubMed
  • Gilmore DM, Khullar OV, Jaklitsch MT, Chirieac LR, Frangioni JV, Colson YL. Identification of metastatic nodal disease in a phase 1 dose-escalation trial of intraoperative sentinel lymph node mapping in non-small cell lung cancer using near-infrared imaging. J Thorac Cardiovasc Surg 2013; 146:562-70; discussion 569-70. PubMed
  • Zubris KA, Liu R, Colby A, Schulz MD, Colson YL, Grinstaff MW. In Vitro Activity of Paclitaxel-Loaded Polymeric Expansile Nanoparticles in Breast Cancer Cells. Biomacromolecules 2013. PubMed
  • Colby AH, Colson YL, Grinstaff MW. Microscopy and tunable resistive pulse sensing characterization of the swelling of pH-responsive, polymeric expansile nanoparticles. Nanoscale 2013; 5:3496-504. PubMed
  • Gilmore DM, Khullar OV, Gioux S, Stockdale A, Frangioni JV, Colson YL, Russell SE. Effective Low-dose Escalation of Indocyanine Green for Near-infrared Fluorescent Sentinel Lymph Node Mapping in Melanoma. Ann Surg Oncol 2013. PubMed
  • Liu R, Gilmore DM, Zubris KA, Xu X, Catalano PJ, Padera RF, Grinstaff MW, Colson YL. Prevention of nodal metastases in breast cancer following the lymphatic migration of paclitaxel-loaded expansile nanoparticles. Biomaterials 2012; 34:1810-9. PubMed
  • Khullar OV, Gilmore DM, Matsui A, Ashitate Y, Colson YL. Preclinical study of near-infrared-guided sentinel lymph node mapping of the porcine lung. Ann Thorac Surg 2012; 95:312-8. PubMed
  • Gilmore D, Colson YL. Recurrent Chylous Pericardial Effusion and Left Neck Mass. Thorac Cardiovasc Surg 2012. PubMed
  • Gilmore D, Schulz M, Liu R, Zubris KA, Padera RF, Catalano PJ, Grinstaff MW, Colson YL. Cytoreductive Surgery and Intraoperative Administration of Paclitaxel-loaded Expansile Nanoparticles Delay Tumor Recurrence in Ovarian Carcinoma. Ann Surg Oncol 2012. PubMed
  • Gilmore DM, Khullar OV, Colson YL. Developing intrathoracic sentinel lymph node mapping with near-infrared fluorescent imaging in non-small cell lung cancer. J Thorac Cardiovasc Surg 2012; 144:S80-4. PubMed
  • Liu R, Khullar OV, Griset AP, Wade JE, Zubris KA, Grinstaff MW, Colson YL. Paclitaxel-loaded expansile nanoparticles delay local recurrence in a heterotopic murine non-small cell lung cancer model. Ann Thorac Surg 2011; 91:1077-84. PubMed
  • Colson YL, Liu R, Southard EB, Schulz MD, Wade JE, Griset AP, Zubris KA, Padera RF, Grinstaff MW. The performance of expansile nanoparticles in a murine model of peritoneal carcinomatosis. Biomaterials 2010; 32:832-40. PubMed
  • Zubris KA, Khullar OV, Griset AP, Gibbs-Strauss S, Frangioni JV, Colson YL, Grinstaff MW. Ease of synthesis, controllable sizes, and in vivo large-animal-lymph migration of polymeric nanoparticles. ChemMedChem 2010; 5:1435-8. PubMed
  • Wolinsky JB, Liu R, Walpole J, Chirieac LR, Colson YL, Grinstaff MW. Prevention of in vivo lung tumor growth by prolonged local delivery of hydroxycamptothecin using poly(ester-carbonate)-collagen composites. J Control Release 2010; 144:280-7. PubMed
  • Schulz MD, Khullar O, Frangioni JV, Grinstaff MW, Colson YL. Nanotechnology in thoracic surgery. Ann Thorac Surg 2010; 89:S2188-90. PubMed
  • Schulz MD, Gill RR, Colson YL. Ipsilateral intralobar and subphrenic pulmonary sequestration. Ann Thorac Surg 2010; 89:2017-9. PubMed
  • Winer JH, Choi HS, Gibbs-Strauss SL, Ashitate Y, Colson YL, Frangioni JV. Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light. Ann Surg Oncol 2010; 17:1094-100. PubMed
  • Wolf AS, Jacobson FL, Tilleman TR, Colson Y, Richards WG, Sugarbaker DJ. Managing the pneumonectomy space after extrapleural pneumonectomy: postoperative intrathoracic pressure monitoring. 2010; 37:770-5. PubMed
  • Liu R, Wolinsky JB, Walpole J, Southard E, Chirieac LR, Grinstaff MW, Colson YL. Prevention of local tumor recurrence following surgery using low-dose chemotherapeutic polymer films. Ann Surg Oncol 2010; 17:1203-13. PubMed
  • Khullar O, Colson YL. The underfunding of lung cancer research. J Thorac Cardiovasc Surg 2009; 138:275. PubMed
  • Griset AP,Walpole J,Liu R,Gaffey A,Colson YL,Grinstaff MW. Expansile nanoparticles: synthesis, characterization, and in vivo efficacy of an acid-responsive polymeric drug delivery system. J Am Chem Soc 2009; 131:2469-71. PubMed
  • Stewart AJ,Mutyala S,Holloway CL,Colson YL,Devlin PM. Intraoperative seed placement for thoracic malignancy-A review of technique, indications, and published literature. Brachytherapy 2008; 8:63-9. PubMed
  • Gill RR,Poh AC,Camp PC,Allen JM,Delano MT,Jacobson FL,Hunsaker A,Colson YL. MDCT evaluation of central airway and vascular complications of lung transplantation. AJR Am J Roentgenol 2008; 191:1046-56. PubMed
  • Camp PL,Colson YL. Invited commentary. Ann Thorac Surg 2008; 85:1900. PubMed
  • Azouz SM, Walpole J, Amirifeli S, Taylor KN, Grinstaff MW, Colson YL. Prevention of local tumor growth with paclitaxel-loaded microspheres. J Thorac Cardiovasc Surg 2008; 135:1014-21. PubMed
  • Sanders JL, Colson YL. Leveraging Primary Care in the Fight Against Lung Cancer. J Gen Intern Med 2008; 23:344-7. PubMed
  • Linden PA, Wee JO, Jaklitsch MT, Colson YL. Extending indications for radiofrequency ablation of lung tumors through an intraoperative approach. Ann Thorac Surg 2008; 85:420-3. PubMed
  • Taylor KN,Laszkowska M,Cohick E,Colson YL. Induction of FoxP3+CD4+CD25+ regulatory T cells by a bone marrow population distinct from plasmacytoid-DC. Cell Immunol 2008; 251:43-9. PubMed
  • Chang MY, Mentzer SJ, Colson YL, Linden PA, Jaklitsch MT, Lipsitz SR, Sugarbaker DJ. Factors predicting poor survival after resection of stage IA non-small cell lung cancer. J Thorac Cardiovasc Surg 2007; 134:850-6. PubMed
  • Tolaney SM, Colson YL, Gill RR, Schulte S, Duggan MM, Shulman LN, Winer EP. Sarcoidosis mimicking metastatic breast cancer. Clin Breast Cancer 2007; 7:804-10. PubMed
  • Linden PA, Bueno R, Mentzer SJ, Zellos L, Lebenthal A, Colson YL, Sugarbaker DJ, Jaklitsch MT. Modified T-tube repair of delayed esophageal perforation results in a low mortality rate similar to that seen with acute perforations. Ann Thorac Surg 2007; 83:1129-33. PubMed
  • Parungo CP, Soybel DI, Colson YL, Kim SW, Ohnishi S, DeGrand AM, Laurence RG, Soltesz EG, Chen FY, Cohn LH, Bawendi MG, Frangioni JV. Lymphatic drainage of the peritoneal space: a pattern dependent on bowel lymphatics. Ann Surg Oncol 2006; 14:286-98. PubMed
  • Ozols RF, Herbst RS, Colson YL, Gralow J, Bonner J, Curran WJ, Eisenberg BL, Ganz PA, Kramer BS, Kris MG, Markman M, Mayer RJ, Raghavan D, Reaman GH, Sawaya R, Schilsky RL, Schuchter LM, Sweetenham JW, Vahdat LT, Winn RJ,. Clinical cancer advances 2006: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology. J Clin Oncol 2006; 25:146-62. PubMed
  • Taylor KN, Shinde Patil VR, Colson YL. Reconstitution of allogeneic hemopoietic stem cells: the essential role of FcR gamma and the TCR beta-chain-FCp33 complex. J Immunol 2006; 177:1444-50. PubMed
  • Paul S, Marty FM, Colson YL. Treatment of cavitary pulmonary zygomycosis with surgical resection and posaconazole. Ann Thorac Surg 2006; 82:338-40. PubMed
  • Mery CM, Pappas AN, Bueno R, Colson YL, Linden P, Sugarbaker DJ, Jaklitsch MT. Similar long-term survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the surveillance, epidemiology, and end results database. Chest 2005; 128:237-45. PubMed
  • Linden PA, Bueno R, Colson YL, Jaklitsch MT, Lukanich J, Mentzer S, Sugarbaker DJ. Lung resection in patients with preoperative FEV1 < 35% predicted. Chest 2005; 127:1984-90. PubMed
  • Parungo CP, Colson YL, Kim SW, Kim S, Cohn LH, Bawendi MG, Frangioni JV. Sentinel lymph node mapping of the pleural space. Chest 2005; 127:1799-804. PubMed
  • Tatli S, Yucel EK, Couper GS, Henderson JM, Colson YL. Aneurysm of an aberrant systemic artery to the lung. AJR Am J Roentgenol 2005; 184:1241-4. PubMed
  • Parungo CP, Ohnishi S, Kim SW, Kim S, Laurence RG, Soltesz EG, Chen FY, Colson YL, Cohn LH, Bawendi MG, Frangioni JV. Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging. J Thorac Cardiovasc Surg 2005; 129:844-50. PubMed
  • Colson YL, Christopher K, Glickman J, Taylor KN, Wright R, Perkins DL. Absence of clinical GVHD and the in vivo induction of regulatory T cells after transplantation of facilitating cells. Blood 2004; 104:3829-35. PubMed
  • Byrne JG, Karavas AN, Colson YL, Bueno R, Richards WG, Sugarbaker DJ, Goldhaber SZ. Cardiac decortication (epicardiectomy) for occult constrictive cardiac physiology after left extrapleural pneumonectomy. Chest 2002; 122:2256-9. PubMed
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