Photo of Zachary David Nagel,  PhD

Zachary David Nagel, PhD

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-1021


znagel@hsph.harvard.edu

Zachary David Nagel, PhD

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Assistant Professor, Environmental Health, Harvard T.H. Chan School Of Public Health

DF/HCC PROGRAM AFFILIATION

Publications

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  • Nagel ZD, Kitange GJ, Gupta SK, Joughin BA, Chaim IA, Mazzucato P, Lauffenburger DA, Sarkaria JN, Samson LD. DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme. Cancer Res 2016; 77:198-206. PubMed
  • Beharry AA, Nagel ZD, Samson LD, Kool ET. Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response. PLoS ONE 2016; 11:e0152684. PubMed
  • McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. Cancer Res 2015; 75:3127-38. PubMed
  • Nagel ZD, Chaim IA, Samson LD. Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research. DNA Repair (Amst) 2014; 19:199-213. PubMed
  • Nagel ZD, Margulies CM, Chaim IA, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD. Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis. Proc Natl Acad Sci U S A 2014; 111:E1823-32. PubMed
  • Nagel ZD, Cun S, Klinman JP. Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases. J Biol Chem 2013; 288:14087-97. PubMed
  • Nagel ZD, Meadows CW, Dong M, Bahnson BJ, Klinman JP. Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures. Biochemistry 2012; 51:4147-56. PubMed
  • Nagel ZD, Dong M, Bahnson BJ, Klinman JP. Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors. Proc Natl Acad Sci U S A 2011; 108:10520-5. PubMed
  • Nagel ZD, Klinman JP. A 21st century revisionist's view at a turning point in enzymology. Nat Chem Biol 2009; 5:543-50. PubMed