The overall objectives of our laboratory are to explore biological mechanisms of tumors arising in bone and other tissues. One of the major focuses of the lab is to elucidate the mechanisms of the development of drug resistance in cancer. Previously, we have found multidrug resistance could be partially reversed by siRNA targeting of ABCB1 (MDR1) or by combination of nanoparticles with chemotherapy drug. Recently, we have identified two small molecules that can overcome drug resistance in vitro. Another significant aim of our research is to define the essential kinases that are responsible for proliferation and survival of human sarcoma cells. In addition, translational research into new treatment options for sarcoma patients has been undertaken.