Photo of Zhi-Min Yuan,   M.D. M.S. Ph.D.

Zhi-Min Yuan, M.D. M.S. Ph.D.

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-2139

Zhi-Min Yuan, M.D. M.S. Ph.D.

Harvard T.H. Chan School Of Public Health


  • Professor, Genetics and Complex Diseases, Harvard T.H. Chan School Of Public Health
  • Director, John B. Little Center, Harvard T.H. Chan School Of Public Health


Research Abstract

Functional characterization of the p53 pathway has been a major research area of my laboratory for more than 10 years. Apart from the characterization of signals and pathways important for p53 regulation, we’ve also investigated the biological function of p53 under normal and pathological conditions. Our understanding of p53 biology has

reached to the point where we are actively conducting translational research to explore the therapeutic potential of p53.

Our research also involves the DNA damage responses, radiation-induced response in particular. We are interested inelucidation of the signaling mechanisms that regulate cellular response to stress and in examining how stress is converted into intracellular signals that control cell behavior in the context of carcinogenesis. Our long-term goal is to gain a better understanding of the biology of carcinogenesis, which would then allow us to design effective strategies for prevention, early detection, and treatment of cancer.


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  • Liu XS, Genet MD, Haines JE, Mehanna EK, Wu S, Chen HI, Chen Y, Qureshi AA, Han J, Chen X, Fisher DE, Pandolfi PP, Yuan ZM. ZBTB7A suppresses melanoma metastasis by transcriptionally repressing MCAM. Mol Cancer Res 2015. PubMed
  • Liu XS, Little JB, Yuan ZM. Glycolytic metabolism influences global chromatin structure. 2015; 6:4214-25. PubMed
  • Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes Dev 2014; 28:1917-28. PubMed
  • Ganapathy S, Xiao S, Yang M, Qi M, Choi DE, Ha CS, Little JB, Yuan ZM. A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection. J Biol Chem 2014; 289:5340-7. PubMed
  • Lehtinen MK, Yuan Z, Boag PR, Yang Y, Vill. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 2006; 125:987-1001. PubMed