Photo of Zhi-Min Yuan,   M.D. M.S. Ph.D.

Zhi-Min Yuan, M.D. M.S. Ph.D.

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-2139


zyuan@hsph.harvard.edu

Zhi-Min Yuan, M.D. M.S. Ph.D.

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Professor, Genetics and Complex Diseases, Harvard T.H. Chan School Of Public Health
  • Director, John B. Little Center, Harvard T.H. Chan School Of Public Health

DF/HCC PROGRAM AFFILIATION

Research Abstract

Functional characterization of the p53 pathway has been a major research area of my laboratory for more than 10 years. Apart from the characterization of signals and pathways important for p53 regulation, we’ve also investigated the biological function of p53 under normal and pathological conditions. Our understanding of p53 biology has

reached to the point where we are actively conducting translational research to explore the therapeutic potential of p53.

Our research also involves the DNA damage responses, radiation-induced response in particular. We are interested inelucidation of the signaling mechanisms that regulate cellular response to stress and in examining how stress is converted into intracellular signals that control cell behavior in the context of carcinogenesis. Our long-term goal is to gain a better understanding of the biology of carcinogenesis, which would then allow us to design effective strategies for prevention, early detection, and treatment of cancer.

Publications

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  • Liu XS, Genet MD, Haines JE, Mehanna EK, Wu S, Chen HI, Chen Y, Qureshi AA, Han J, Chen X, Fisher DE, Pandolfi PP, Yuan ZM. ZBTB7A suppresses melanoma metastasis by transcriptionally repressing MCAM. Mol Cancer Res 2015. PubMed
  • Liu XS, Little JB, Yuan ZM. Glycolytic metabolism influences global chromatin structure. 2015; 6:4214-25. PubMed
  • Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes Dev 2014; 28:1917-28. PubMed
  • Ganapathy S, Xiao S, Yang M, Qi M, Choi DE, Ha CS, Little JB, Yuan ZM. A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection. J Biol Chem 2014; 289:5340-7. PubMed
  • Lehtinen MK, Yuan Z, Boag PR, Yang Y, Vill. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 2006; 125:987-1001. PubMed
  • Gu J, Chen D, Rosenblum J, Rubin RM, Yuan ZM. Identification of a sequence element from p53 that signals for Mdm2-targeted degradation. Mol Cell Biol 2000; 20:1243-53. PubMed
  • Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 1999; 399:814-7. PubMed
  • Yuan J, Yankner BA. Caspase activity sows the seeds of neuronal death. Nat Cell Biol 1999; 1:E44-5. PubMed
  • Huang Y, Nakada S, Ishiko T, Utsugisawa T, Datta R, Kharbanda S, Yoshida K, Talanian RV, Weichselbaum R, Kufe D, Yuan ZM. Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage. Mol Cell Biol 1999; 19:2986-97. PubMed
  • Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Yokoyama K, Weichselbaum R, Shi Y, Kufe D. Role for p300 in stabilization of p53 in the response to DNA damage. J Biol Chem 1999; 274:1883-6. PubMed
  • Rodela H, Yuan Z, Johnston MG. Role of protein kinase C in the regulation of pumping activity in bovine mesenteric lymphatic vessels. Lymphology 1998; 31:4-14. PubMed
  • Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kharbanda S, Wang R, Sung P, Shinohara A, Weichselbaum R, Kufe D. Regulation of Rad51 function by c-Abl in response to DNA damage. J Biol Chem 1998; 273:3799-802. PubMed
  • Kharbanda S, Yuan ZM, Weichselbaum R, Kufe D. Functional role for the c-Abl protein tyrosine kinase in the cellular response to genotoxic stress. Biochim Biophys Acta 1997; 1333:O1-7. PubMed
  • Huang Y, Yuan ZM, Ishiko T, Nakada S, Utsugisawa T, Kato T, Kharbanda S, Kufe DW. Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine. Oncogene 1997; 15:1947-52. PubMed
  • Yuan ZM, Utsugisawa T, Huang Y, Ishiko T, Nakada S, Kharbanda S, Weichselbaum R, Kufe D. Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response. J Biol Chem 1997; 272:23485-8. PubMed
  • Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kato T, Yuan ZM. Role for E2F in DNA damage-induced entry of cells into S phase. Cancer Res 1997; 57:3640-3. PubMed
  • Kharbanda S, Pandey P, Schofield L, Israels S, Roncinske R, Yoshida K, Bharti A, Yuan ZM, Saxena S, Weichselbaum R, Nalin C, Kufe D. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci U S A 1997; 94:6939-42. PubMed
  • Kharbanda S, Pandey P, Jin S, Inoue S, Bharti A, Yuan ZM, Weichselbaum R, Weaver D, Kufe D. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature 1997; 386:732-5. PubMed
  • Yuan ZM, Huang Y, Ishiko T, Kharbanda S, Weichselbaum R, Kufe D. Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc Natl Acad Sci U S A 1997; 94:1437-40. PubMed
  • Yuan ZM, Huang Y, Whang Y, Sawyers C, Weichselbaum R, Kharbanda S, Kufe D. Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature 1996; 382:272-4. PubMed
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