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Nature Medicine

Nature Medicine is the premier journal for biomedical research. Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic research and medical advances and is consistently ranked the number one journal by the Institute of Scientific Investigation in the Medicine, Research and Experimental category.
Nature Medicine
The international response to the ongoing Ebola epidemic has in many respects been more reactive than proactive. But there are changes that, if made, may shift the balance toward future readiness.










Mesenchymal stromal cells are key components of hematopoietic stem cell (HSC) niches in the bone marrow. Two studies now show that hematopoietic-derived megakaryocytes also contribute to the HSC niche, regulating HSC quiescence and function.

A recent study reports that de novo fatty acid synthesis is important for differentiation of T helper 17 (TH17) cells. Suppression of this pathway through inhibition of acetyl-CoA carboxylase (ACC) with soraphen A prevents TH17 cell differentiation and consequently enforces a regulatory T cell phenotype.

Truncation of tau contributes to the formation of neurofibrillary tangles in Alzheimer's disease. A new study finds a direct role for a lysosomal cysteine protease, asparagine endopeptidase, in cleaving tau into neurotoxic fragments.

Preosteoclasts give rise to bone-resorbing osteoclasts, which are crucial for skeletal homeostasis. A study now shows that preosteoclasts also contribute to bone formation by releasing platelet-derived growth factor-BB, which promotes bone vascularization and osteogenesis.






Tau cleavage and aggregation, key processes in many neurodegenerative diseases, can be reduced by blocking the activity of a protease called asparagine endopeptidase.

By acting as a mild mitochondrial uncoupler, a derivative of the approved drug niclosamide may offer a new approach to treat diabetes.

Preostoclasts secrete PDGF-BB to promote angiogenesis in the bone, promoting bone homeostasis and preventing bone loss in an osteoporosis model.

A new study shows that Wnt16 inhibits osteoclast formation, suggesting it may be a possible therapeutic option for treating bone fractures in osteoporosis.

Activation of the transcription factor FoxO1 ameliorates vascular remodeling in pulmonary hypertension, pointing to a potential new therapeutic strategy for this disease.

Anthracyclines can induce a type 1 interferon response in tumor cells that may predict clinical response to these drugs.

An in vivo model of the human small intestine is established in mice using human pluripotent stem cells.

Two papers in this issue, by Bruns et al. and Zhao et al., show that megakaryocytes constitute a niche for hematopoietic stem cells in the mouse bone marrow and produce factors that regulate hematopoietic stem cell quiescence and proliferation.

Two papers in this issue, by Bruns et al. and Zhao et al., show that megakaryocytes constitute a niche for hematopoietic stem cells in the mouse bone marrow and produce factors that regulate hematopoietic stem cell quiescence and proliferation.

TH17 and Treg cell development are reciprocally regulated by de novo fatty acid synthesis, and inhibition of acetyl-CoA carboxylase 1 (ACC1) attenuates TH17 cell–mediated autoimmune disease.

The gut microbiota promotes regulatory B cell development and function through interleukin-1β and interleukin-6.

The next generation of genetically engineered mouse models of pancreatic cancer involving a new inducible dual-recombinase system that combines Flp-FRT and Cre-loxP.

Tichauer et al. describe a dual-tracer approach to quantify cancer cell receptor concentrations, in this case epidermal growth factor receptor, in lymph nodes, that can also correct for nonspecific uptake.