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Nature Medicine

Nature Medicine is the premier journal for biomedical research. Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic research and medical advances and is consistently ranked the number one journal by the Institute of Scientific Investigation in the Medicine, Research and Experimental category.
Nature Medicine
The size, speed and potential reach of the 2014 Ebola virus outbreak in West Africa presents a wake-up call to the research and pharmaceutical communities—and to federal governments—of the continuing need to invest resources in the study and cure of emerging infectious diseases.

Disrupted differentiation of Schwann cells contributes to axonal loss in a rat model of Charcot-Marie-Tooth 1A neuropathy. Early neuregulin-1 treatment promotes Schwann cell differentiation, preserves axons and restores nerve function in this model.

Aging and a high-fat diet are predisposing factors for type 2 diabetes. A study in mice suggests that dietary fat and aging lead to atypical transforming growth factor-β1 signaling in the hypothalamus, which disturbs whole-body glucose regulation.

Mutations in the DMD gene, encoding dystrophin, cause the most common forms of muscular dystrophy. A new study shows that forcing translation of DMD from an internal ribosome entry site can alleviate Duchenne muscular dystrophy symptoms in a mouse model.

Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8αβ+NKG2D+ T effector memory cells mediate alopecia areata in part through Janus kinase (JAK) signaling and that alopecia areata might be treated with JAK inhibitors.

A novel internal ribosomal entry site in the 5' end of the dystrophin gene allows for expression of a form of the protein that could be therapeutic for certain forms of Duchenne muscular dystrophy.

Obesity and aging result in elevated levels of central TGF-β, resulting in hypothalamic inflammation and the development of type 2 diabetes.

Wnt4 promotes bone growth while inhibiting bone loss to prevent osteopenia in a mouse model.

Manipulation of acetate levels in mice can affect the activity of the hypoxia-responsive transcription factor HIF-2α and facilitate recovery from anemia.

Activation of the insulin-like growth factor 1 receptor may underlie clinical resistance to inhibition of the anaplastic lymphoma receptor kinase in lung cancer.

Deficiency in Gnas, encoding the Gs protein α subunit, is sufficient to induce medulloblastoma in mice due to derepression of the Sonic hedgehog pathway.

Cytotoxic T cells are necessary and sufficient for the development of alopecia areata in mice, while JAK inhibition promotes regrowth of hair in patients and mice with established disease.

Blocking the binding between two proteins whose interaction is increased during stress can reduce anxiety in mouse models.

Postnatal administration of neuregulin-1 into rodent models of the peripheral neuropathy Charcot-Marie-Tooth disease can ameliorate motor symptoms.

Proteomic-imaging analysis of caveolae shows active transvascular pumping of antibodies across the endothelial cell barrier and into solid tumors against a concentration gradient.

Continuous 24-hour intraocular pressure self-monitoring device for glaucoma management using an implantable sensor with smartphone readout.