Photo of Rebecca A. Betensky,  PhD

Rebecca A. Betensky, PhD

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-2821
Fax: (617) 432-5619


betensky@hsph.harvard.edu

Rebecca A. Betensky, PhD

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Professor, Biostatistics, Harvard T.H. Chan School Of Public Health
  • Biostatistician, MGH Biostatistics Center, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Betensky's research is currently focused on the development of new methods of the analysis of multi-dimensional clustered binary data and interval censored data. She has applied these methods to physician recommendations for early prostate cancer treatment, a designed experiment of an immunologic assay, AIDS clincal trials, and family studies of multiple diseases.

Publications

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  • Betensky RA. Measures of follow-up in time-to-event studies: Why provide them and what should they be? Clin Trials 2015; 12:403-8. PubMed
  • Betensky RA, Szymonifka J, Lee EQ, Nutt CL, Batchelor TT. Computationally simple analysis of matched, outcome-based studies of ordinal disease states. Stat Med 2015; 34:2514-27. PubMed
  • Taylor JW, Dietrich J, Gerstner ER, Norden AD, Rinne ML, Cahill DP, Stemmer-Rachamimov A, Wen PY, Betensky RA, Giorgio DH, Snodgrass K, Randall AE, Batchelor TT, Chi AS. Phase 2 study of bosutinib, a Src inhibitor, in adults with recurrent glioblastoma. J. Neurooncol. 2015. PubMed
  • Chheda MG, Wen PY, Hochberg FH, Chi AS, Drappatz J, Eichler AF, Yang D, Beroukhim R, Norden AD, Gerstner ER, Betensky RA, Batchelor TT. Vandetanib plus sirolimus in adults with recurrent glioblastoma: results of a phase I and dose expansion cohort study. J. Neurooncol. 2015. PubMed
  • Taylor JW, Flanagan EP, O'Neill BP, Siegal T, Omuro A, Deangelis L, Baehring J, Nishikawa R, Pinto F, Chamberlain M, Hoang-Xuan K, Gonzalez-Aguilar A, Batchelor T, Blay JY, Korfel A, Betensky RA, Lopes MB, Schiff D. Primary leptomeningeal lymphoma: International Primary CNS Lymphoma Collaborative Group report. Neurology 2013; 81:1690-6. PubMed
  • Waikar SS, Betensky RA, Emerson SC, Bonventre JV. Imperfect gold standards for biomarker evaluation. Clin Trials 2013; 10:696-700. PubMed
  • Mi MY, Betensky RA. An analysis of adaptive design variations on the sequential parallel comparison design for clinical trials. Clin Trials 2013; 10:207-15. PubMed
  • Bijron JG, Ning G, Laury AR, Quick CM, Betensky RA, Monte NM, King E, McKeon FD, Xian W, Crum CP. Digital quantification of precursor frequency in the fallopian tube and its significance. Mod Pathol 2012. PubMed
  • Mohapatra G, Engler DA, Starbuck KD, Kim JC, Bernay DC, Scangas GA, Rousseau A, Batchelor TT, Betensky RA, Louis DN. Genome-wide comparison of paired fresh frozen and formalin-fixed paraffin-embedded gliomas by custom BAC and oligonucleotide array comparative genomic hybridization: facilitating analysis of archival gliomas. Acta Neuropathol 2011; 121:529-43. PubMed
  • Abla O, Weitzman S, Blay JY, O'Neill BP, Abrey LE, Neuwelt E, Doolittle ND, Baehring J, Pradhan K, Martin SE, Guerrera M, Shah S, Ghesquieres H, Silver M, Betensky RA, Batchelor T. Primary CNS lymphoma in children and adolescents: a descriptive analysis from the International Primary CNS Lymphoma Collaborative Group (IPCG). Clin Cancer Res 2011; 17:346-52. PubMed
  • Spires-Jones TL, Kay K, Matsouka R, Rozkalne A, Betensky RA, Hyman BT. Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain. Neurosci Lett 2010; 487:260-3. PubMed
  • Desantis SM,Houseman EA,Coull BA,Louis DN,Mohapatra G,Betensky RA. A Latent Class Model with Hidden Markov Dependence for Array CGH Data. Biometrics 2009; 65:1296-305. PubMed
  • Waikar SS, Betensky RA, Bonventre JV. Creatinine as the gold standard for kidney injury biomarker studies? Nephrol. Dial. Transplant. 2009; 24:3263-5. PubMed
  • Snuderl M, Eichler AF, Ligon KL, Vu QU, Silver M, Betensky RA, Ligon AH, Wen PY, Louis DN, Iafrate AJ. Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss. Clin Cancer Res 2009; 15:6430-7. PubMed
  • Gabeau-Lacet D, Engler D, Gupta S, Scangas GA, Betensky RA, Barker FG, Loeffler JS, Louis DN, Mohapatra G. Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome. J Neuropathol Exp Neurol 2009; 68:1155-65. PubMed
  • Gabeau-Lacet D,Aghi M,Betensky RA,Barker FG,Loeffler JS,Louis DN. Bone involvement predicts poor outcome in atypical meningioma. J Neurosurg 2009; 111:464-71. PubMed
  • Stankovic KM, Mrugala MM, Martuza RL, Silver M, Betensky RA, Nadol JB, Stemmer-Rachamimov AO. Genetic determinants of hearing loss associated with vestibular schwannomas. Otol. Neurotol. 2009; 30:661-7. PubMed
  • Zhu JJ,Gerstner ER,Engler DA,Mrugala MM,Nugent W,Nierenberg K,Hochberg FH,Betensky RA,Batchelor TT. High-dose methotrexate for elderly patients with primary CNS lymphoma. Neuro-oncol 2008; 11:211-5. PubMed
  • Shen Y, Nunes F, Stemmer-Rachamimov A, James M, Mohapatra G, Plotkin S, Betensky RA, Engler DA, Roy J, Ramesh V, Gusella JF. Genomic profiling distinguishes familial multiple and sporadic multiple meningiomas. BMC Med Genomics 2009; 2:42. PubMed
  • Stamoulis C, Betensky RA, Mohapatra G, Louis DN. Application of signal processing techniques for estimating regions of copy number variations in human meningioma DNA. Conf Proc IEEE Eng Med Biol Soc 2009; 2009:6973-6. PubMed
  • Vaidya VS,Waikar SS,Ferguson MA,Collings FB,Sunderland K,Gioules C,Bradwin G,Matsouaka R,Betensky RA,Curhan GC,Bonventre JV. Urinary Biomarkers for Sensitive and Specific Detection of Acute Kidney Injury in Humans. Clin Transl Sci 2009; 1:200-208. PubMed
  • Matthews AG,Finkelstein DM,Betensky RA. Analysis of familial aggregation studies with complex ascertainment schemes. Stat Med 2008; 27:5076-92. PubMed
  • Patil S, Perry A, Maccollin M, Dong S, Betensky RA, Yeh TH, Gutmann DH, Stemmer-Rachamimov AO. Immunohistochemical Analysis Supports a Role for INI1/SMARCB1 in Hereditary Forms of Schwannomas, but Not in Solitary, Sporadic Schwannomas. Brain Pathol 2008; 18:517-9. PubMed
  • Mandel M, Betensky RA. Estimating time-to-event from longitudinal ordinal data using random-effects Markov models: application to multiple sclerosis progression. Biostatistics 2008; 9:750-64. PubMed
  • Snuderl M,Chi SN,De Santis SM,Stemmer-Rachamimov AO,Betensky RA,De Girolami U,Kieran MW. Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas. J Neuropathol Exp Neurol 2008; 67:911-20. PubMed
  • Desantis SM, Houseman EA, Coull BA, Stemmer-Rachamimov A, Betensky RA. A penalized latent class model for ordinal data. Biostatistics 2007; 9:249-62. PubMed
  • Voloschin AD, Betensky R, Wen PY, Hochberg F, Batchelor T. Topotecan as salvage therapy for relapsed or refractory primary central nervous system lymphoma. J Neurooncol 2007; 86:211-5. PubMed
  • Betensky RA, Louis DN, Cairncross JG. Tests of association under misclassification: Application to histological sampling in oncology. Stat Med 2007; 26:4808-16. PubMed
  • Mandel M, Betensky RA. Testing goodness of fit of a uniform truncation model. Biometrics 2007; 63:405-12. PubMed
  • Matthews AG, Finkelstein DM, Betensky RA. Multivariate logistic regression for familial aggregation in age at disease onset. Lifetime Data Analysis 2007; 13:191-209. PubMed
  • Cahill DP, Levine KK, Betensky RA, Codd PJ, Romany CA, Reavie LB, Batchelor TT, Futreal PA, Stratton MR, Curry WT, Iafrate AJ, Louis DN. Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. Clin Cancer Res 2007; 13:2038-45. PubMed
  • Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci 2007; 27:1973-80. PubMed
  • Rousseau A, Nutt CL, Betensky RA, Iafrate AJ, Han M, Ligon KL, Rowitch DH, Louis DN. Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2. J Neuropathol Exp Neurol 2006; 65:1149-56. PubMed
  • Pierie JP, Betensky RA, Choudry U, Willett CG, Souba WW, Ott MJ. Outcomes in a series of 103 retroperitoneal sarcomas. Eur J Surg Oncol 2006; 32:1235-41. PubMed
  • Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis 2006; 24:516-24. PubMed
  • Mizoguchi M, Betensky RA, Batchelor TT, Bernay DC, Louis DN, Nutt CL. Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival. J Neuropathol Exp Neurol 2006; 65:1181-8. PubMed
  • Houseman EA, Coull BA, Betensky RA. Feature-specific penalized latent class analysis for genomic data. Biometrics 2006; 62:1062-70. PubMed
  • Baehring JM, Hochberg FH, Betensky RA, Longtine J, Sklar J. Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes. J Neurol Sci 2006; 247:208-16. PubMed
  • Scholtens D, Betensky RA. A computationally simple bivariate survival estimator for efficacy and safety. Lifetime Data Analysis 2006; 12:365-87. PubMed
  • Houseman EA, Coull BA, Betensky RA.. Feature-sepcific constrained latent class analysis for medium throughput genomic data. Survey Methodol 2006.
  • Coull BA, Houseman EA, Betensky R. A computationally efficient multivariate random effects model for clustered binary data. Biometrika 2006; 93:587-599.
  • Zhang B, Betensky RA. Methods to classify familial relationships in the presence of laboratory errors, without parental data. Hum Genet 2006; 119:642-8. PubMed
  • Engler DA, Mohapatra G, Louis DN, Betensky RA. A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations. Biostatistics 2006; 7:399-421. PubMed
  • Goldfine AB, Beckman JA, Betensky RA, Devlin H, Hurley S, Varo N, Schonbeck U, Patti ME, Creager MA. Family history of diabetes is a major determinant of endothelial function. J Am Coll Cardiol 2006; 47:2456-61. PubMed
  • Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN. AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer Res 2006; 66:5618-23. PubMed
  • Zhang B, Li Y, Betensky RA. Effects of unmeasured heterogeneity in the linear transformation model for censored data. Lifetime Data Anal 2006; 12:191-203. PubMed
  • Betensky RA, Christian CK, Gustafson ML, Daley J, Zinner MJ. Hospital volume versus outcome: an unusual example of bivariate association. Biometrics 2006; 62:598-604. PubMed
  • Mohapatra G, Betensky RA, Miller ER, Carey B, Gaumont LD, Engler DA, Louis DN. Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization. J Mol Diagn 2006; 8:268-76. PubMed
  • Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci 2006; 26:365-71. PubMed
  • Plotkin SR, Betensky RA, Hochberg FH, Grossman SA, Lesser GJ, Nabors LB, Chon B, Batchelor TT. Treatment of relapsed central nervous system lymphoma with high-dose methotrexate. Clin Cancer Res 2004; 10:5643-6. PubMed
  • Stamoulis C, Betensky RA. Optimization of Signal Decomposition Matched Filtering (SDMF) for Improved Detection of Copy-Number Variations. IEEE/ACM Trans Comput Biol Bioinform 2016; 13:584-91. PubMed
  • Coull BA, Houseman EA, Betensky RA. A computationally tractable multivariate random effects model for clustered binary data Biometrika 2006; 93:587-599.
  • Li Y, Shih M, Betensky R. Designed Extension of Survival Studies: Applicatino to Clinical Trials with Unrecognized Heterogeneity Stat Sin 2007; 17:1567-1589.
  • Li Y, Shih M, Betensky R. Designed extension of survival studies: Application to clinical trials with unrecognized heterogeneity. Stat Sin 2007; 17:1567-1589.
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