Photo of Richard A. Hodin,  MD

Richard A. Hodin, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-2570
Fax: (617) 724-2574


rhodin@partners.org

Richard A. Hodin, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Surgery, Harvard Medical School
  • Professor, Surgery, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The long-term objectives of this ongoing project is to elucidate the mechanisms underlying gut mucosal defense. We are particularly interested in understanding the mechanisms that which go awry in a number of gut disease states, including inflammatory conditions, prolonged starvation, systemic trauma and sepsis. as well as cancer.

Publications

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  • De Gregorio L, Lubitz CC, Hodin RA, Gaz RD, Parangi S, Phitayakorn R, Stephen AE. The Truth about Double Adenomas: Incidence, Localization, and Intraoperative Parathyroid Hormone. J Am Coll Surg 2016; 222:1044-52. PubMed
  • Nakagawa A, Adams CE, Huang Y, Hamarneh SR, Liu W, Von Alt KN, Mino-Kenudson M, Hodin RA, Lillemoe KD, Fernández-Del Castillo C, Warshaw AL, Liss AS. Selective and reversible suppression of intestinal stem cell differentiation by pharmacological inhibition of BET bromodomains. Sci Rep 2016; 6:20390. PubMed
  • Kir S, Komaba H, Garcia AP, Economopoulos KP, Liu W, Lanske B, Hodin RA, Spiegelman BM. PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. Cell Metab 2015. PubMed
  • Twerdahl EH, Costantino CL, Ferrone CR, Hodin RA. Primary Hepatic Gastrinoma. J Gastrointest Surg 2015. PubMed
  • Economopoulos KP, Phitayakorn R, Lubitz CC, Sadow PM, Parangi S, Stephen AE, Hodin RA. Should specific patient clinical characteristics discourage adrenal surgeons from performing laparoscopic transperitoneal adrenalectomy? Surgery 2015. PubMed
  • Chen Y, Masiakos PT, Gaz RD, Hodin RA, Parangi S, Randolph GW, Sadow PM, Stephen AE. Pediatric thyroidectomy in a high volume thyroid surgery center: Risk factors for postoperative hypocalcemia. J Pediatr Surg 2015. PubMed
  • Chen Y, Hodin RA, Pandolfi C, Ruan DT, McKenzie TJ. Hypoglycemia after resection of pheochromocytoma. Surgery 2014; 156:1404-8; discussion 1408-9. PubMed
  • Shin J, Carr A, Corner GA, Tögel L, Dávalos-Salas M, Dávaos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, Sieber OM, Augenlicht LH, Dhillon AS, Weber TK, Mariadason JM. The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner. J Biol Chem 2014; 289:25306-16. PubMed
  • Morrison SA, Suh H, Hodin RA. The surgical management of thyroid cancer. Rambam Maimonides Med J 2014; 5:e0008. PubMed
  • Nagarkatti SS, Faquin WC, Lubitz CC, Garcia DM, Barbesino G, Ross DS, Hodin RA, Daniels GH, Parangi S. Management of thyroid nodules with atypical cytology on fine-needle aspiration biopsy. Ann Surg Oncol 2012. PubMed
  • Lubitz CC, Stephen AE, Hodin RA, Pandharipande P. Preoperative localization strategies for primary hyperparathyroidism: an economic analysis. Ann Surg Oncol 2012. PubMed
  • Prescott JD, Sadow PM, Hodin RA, Le LP, Gaz RD, Randolph GW, Stephen AE, Parangi S, Daniels GH, Lubitz CC. BRAF V600E status adds incremental value to current risk classification systems in predicting papillary thyroid carcinoma recurrence. Surgery 2012; 152:984-90. PubMed
  • Lubitz CC, Nagarkatti SS, Faquin WC, Samir AE, Hassan MC, Barbesino G, Ross DS, Randolph GW, Gaz RD, Stephen AE, Hodin RA, Daniels GH, Parangi S. Diagnostic yield of nondiagnostic thyroid nodules is not altered by timing of repeat biopsy. Thyroid 2012; 22:590-4. PubMed
  • Moaven O, Hodin RA. Chilaiditi syndrome: a rare entity with important differential diagnoses. Gastroenterol Hepatol (N Y) 2012; 8:276-8. PubMed
  • Nucera C, Nehs MA, Nagarkatti SS, Sadow PM, Mekel M, Fischer AH, Lin PS, Bollag GE, Lawler J, Hodin RA, Parangi S. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Oncologist 2011; 16:296-309. PubMed
  • Nehs MA, Nagarkatti S, Nucera C, Hodin RA, Parangi S. Thyroidectomy with neoadjuvant PLX4720 extends survival and decreases tumor burden in an orthotopic mouse model of anaplastic thyroid cancer. Surgery 2010; 148:1154-62; discussion 1162. PubMed
  • Nucera C, Lawler J, Hodin R, Parangi S. The BRAFV600E mutation: what is it really orchestrating in thyroid cancer? 2011; 1:751-6. PubMed
  • Klos CL, Shellito PC, Rattner DW, Hodin RA, Cusack JC, Bordeianou L, Sylla P, Hong TS, Blaszkowsky L, Ryan DP, Lauwers GY, Chang Y, Berger DL. The effect of neoadjuvant chemoradiation therapy on the prognostic value of lymph nodes after rectal cancer surgery. Am J Surg 2010; 200:440-5. PubMed
  • Mekel M, Nucera C, Hodin RA, Parangi S. Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules. Am J Surg 2010; 200:136-43. PubMed
  • Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A 2010; 107:10649-54. PubMed
  • Mekel M, Stephen AE, Gaz RD, Randolph GW, Richer S, Perry ZH, Lubitz CC, Nehs MA, Parangi S, Hodin RA. Surgical drains can be safely avoided in lateral neck dissections for papillary thyroid cancer. Am J Surg 2010; 199:485-90. PubMed
  • Lubitz CC, Faquin WC, Yang J, Mekel M, Gaz RD, Parangi S, Randolph GW, Hodin RA, Stephen AE. Clinical and cytological features predictive of malignancy in thyroid follicular neoplasms. Thyroid 2010; 20:25-31. PubMed
  • Mekel M, Stephen AE, Gaz RD, Perry ZH, Hodin RA, Parangi S. Thyroid surgery in octogenarians is associated with higher complication rates. Surgery 2009; 146:913-21. PubMed
  • Henneman D,Chang Y,Hodin RA,Berger DL. Effect of laparoscopy on the indications for adrenalectomy. Arch Surg 2009; 144:255-9; discussion 259. PubMed
  • Kaplan GG, McCarthy EP, Ayanian JZ, Korzenik J, Hodin R, Sands BE. Impact of Hospital Volume on Postoperative Morbidity and Mortality Following a Colectomy for Ulcerative Colitis. Gastroenterology 2008; 134:680-7. PubMed
  • Hodin RA. Gnothi se auton: SUS Presidential Address. Surgery 2007; 142:127-35. PubMed
  • Stephen AE, Roth SI, Fardo DW, Finkelstein DM, Randolph GW, Gaz RD, Hodin RA. Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas. Arch Surg 2007; 142:381-6. PubMed
  • Bordeianou L, Hodin R. Controversies in the surgical management of sigmoid diverticulitis. J Gastrointest Surg 2007; 11:542-8. PubMed
  • Malo MS, Biswas S, Abedrapo MA, Yeh L, Chen A, Hodin RA. The pro-inflammatory cytokines, IL-1beta and TNF-alpha, inhibit intestinal alkaline phosphatase gene expression. DNA Cell Biol 2007; 25:684-95. PubMed
  • Stephen AE, Hodin RA. Neuroendocrine tumors of the pancreas, excluding gastrinoma. Surg Oncol Clin N Am 2006; 15:497-510. PubMed
  • Malo MS, Mozumder M, Chen A, Mostafa G, Zhang XB, Hodin RA. pFRL7: an ideal vector for eukaryotic promoter analysis. Anal Biochem 2006; 350:307-9. PubMed
  • Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JF, Tischler AS, Hodin R, Heitritter S, Moore F, Dluhy R, Sosa JA, Ocal IT, Benn DE, Marsh DJ, Robinson BG, Schneider K, Garber J, Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SP, Nose V, Li C, Stiles CD. A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet 2005; 1:72-80. PubMed
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