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Dennis Sgroi M.D.

Assistant Professor, Department of Pathology, Harvard Medical School

Assistant in Pathology, Department of Pathology, Massachusetts General Hospital

Contact Info

Dennis Sgroi
Massachusetts General Hospital
Building 149, 13th Street
Charlestown, MA, 02129
Mailstop: Molecular Pathology Unit - 7149
Phone: 6177265697
Fax: 6177265684
dsgroi@partners.org

Assistant

Susan Smith
Phone: 6177265690
Fax:
ssmith6@partners.org

DF/HCC Program Affiliation

Member, Cancer Genetics Program
Member, Breast Cancer Program

Publications

  • Leong CO, Vidnovic N, Deyoung MP, Sgroi D, Ellisen LW. The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers. J Clin Invest 2007 Apr 19;
    PMID: 17446929
  • Harris LN, You F, Schnitt SJ, Witkiewicz A, Lu X, Sgroi D, Ryan PD, Come SE, Burstein HJ, Lesnikoski BA, Kamma M, Friedman PN, Gelman R, Iglehart JD, Winer EP. Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin Cancer Res 2007 Feb 15; 13(4):1198-207
    PMID: 17317830
  • Frackelton AR, Lu L, Davol PA, Bagdasaryan R, Hafer LJ, Sgroi DC. p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy. Breast Cancer Res 2006; 8(6):R73
    PMID: 17196107
  • Yang C, Trent S, Ionescu-Tiba V, Lan L, Shioda T, Sgroi D, Schmidt EV. Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression. Cancer Res 2006 Dec 15; 66(24):11649-58
    PMID: 17178859
  • Hartwell KA, Muir B, Reinhardt F, Carpenter AE, Sgroi DC, Weinberg RA. The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A 2006 Dec 12; 103(50):18969-74
    PMID: 17142318
  • Ma XJ, Hilsenbeck SG, Wang W, Ding L, Sgroi DC, Bender RA, Osborne CK, Allred DC, Erlander MG. The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. J Clin Oncol 2006 Oct 1; 24(28):4611-9
    PMID: 17008703
  • Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A 2006 Aug 15; 103(33):12405-10
    PMID: 16894141
  • Goetz MP, Suman VJ, Ingle JN, Nibbe AM, Visscher DW, Reynolds CA, Lingle WL, Erlander M, Ma XJ, Sgroi DC, Perez EA, Couch FJ. A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. Clin Cancer Res 2006 Apr 1; 12(7 Pt 1):2080-7
    PMID: 16609019
  • Wong JS, Kaelin CM, Troyan SL, Gadd MA, Gelman R, Lester SC, Schnitt SJ, Sgroi DC, Silver BJ, Harris JR, Smith BL. Prospective study of wide excision alone for ductal carcinoma in situ of the breast. J Clin Oncol 2006 Mar 1; 24(7):1031-6
    PMID: 16461781
  • Smolen GA, Sordella R, Muir B, Mohapatra G, Barmettler A, Archibald H, Kim WJ, Okimoto RA, Bell DW, Sgroi DC, Christensen JG, Settleman J, Haber DA. Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc Natl Acad Sci U S A 2006 Feb 14; 103(7):2316-21
    PMID: 16461907
  • Sgroi DC, Teng S, Robinson G, LeVangie R, Hudson JR, Elkahloun AG. In vivo gene expression profile analysis of human breast cancer progression. Cancer Res 1999 Nov 15; 59(22):5656-61
    PMID: 10582678
  • Barnes YC, Skelton TP, Stamenkovic I, Sgroi DC. Sialylation of the sialic acid binding lectin sialoadhesin regulates its ability to mediate cell adhesion. Blood 1999 Feb 15; 93(4):1245-52
    PMID: 9949167
  • Sgroi D, Nocks A, Stamenkovic I. A single N-linked glycosylation site is implicated in the regulation of ligand recognition by the I-type lectins CD22 and CD33. J Biol Chem 1996 Aug 2; 271(31):18803-9
    PMID: 8702538