DF/HCC Program Affiliation

Member, Cancer Cell Biology Program

Research Abstract

We are interested in the biological function and mechanism of action of a number of transcriptional regulators that are targets of viral oncoproteins. These proteins include p300/CBP, CtBP and YY1. We are using both genetic (C. elegans and mouse) and biochemical approaches to address relevant questions.

Publications

• Horwitz AA, Affar el B, Heine GF, Shi Y, Parvin JD. A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase. Proc Natl Acad Sci U S A 2007 Apr 17; 104(16):6614-9
  PMID: 17420471
• Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell 2007 Mar 23; 128(6):1077-88
  PMID: 17320160
• Donohoe ME, Zhang LF, Xu N, Shi Y, Lee JT. Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell 2007 Jan 12; 25(1):43-56
  PMID: 17218270
• Sui GC, Affar EB, Shi YJ, Wall N, Brignone C, Yin P, Dohonoe M, Calvo D, Grossman S, Shi Y . Yin Yang 1 is a negative regulator of p53 Cell 2004 June 25; 117:859-872
  PMID: 0
• Shi YJ, Sawada JI, Su GC, Affar EB, Whetstine J, Lan F, Ogawa H, Luke M, Nakatani Y, Shi, Y.. Coordinated histone modifications mediated by a CtBP co-repressor complex Nature 2003 Apr 17; 422:735-738
  PMID: 0
• Sui G, Soohoo C, Affar el B, Gay F, Shi Y, Forrester WC, Shi Y. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A 2002 Apr 16; 99(8):5515-20
  PMID: 11960009