DF/HCC Program Affiliation

Leader, Gastrointestinal Malignancies Program
Member, Cancer Epidemiology Program
Member, Outcomes Research Program

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

I currently conduct research in gastrointestinal cancer epidemiology using data from the Nurses' Health Study, the Health Professionals Follow-up Study, and the Physicians' Health Study. Assess risk factors for stomach, pancreas, and colorectal cancers. In addition to looking at the influence of diet and lifestyle, we are looking at the influence of such biomarkers as insulin-like growth factors, steroid hormones, and polymorphisms of metabolism enzymes on the risk of these cancers. I also conduct research assessing various treatment regimens and new drugs for gastrointestinal cancers

Publications

• Fuchs CS, Marshall J, Mitchell E, Wierzbicki R, Ganju V, Jeffery M, Schulz J, Richards D, Soufi-Mahjoubi R, Wang B, Barrueco J. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. J Clin Oncol 2007 Oct 20; 25(30):4779-86
  PMID: 17947725
• Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Hu FB, Mayer RJ, Nelson H, Whittom R, Hantel A, Thomas J, Fuchs CS. Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer. JAMA 2007 Aug 15; 298(7):754-64
  PMID: 17699009
• Wolpin BM, Michaud DS, Giovannucci EL, Schernhammer ES, Stampfer MJ, Manson JE, Cochrane BB, Rohan TE, Ma J, Pollak MN, Fuchs CS. Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer. Cancer Res 2007 Aug 15; 67(16):7923-8
  PMID: 17699799
• Ogino S, Hazra A, Tranah GJ, Kirkner GJ, Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Meyerhardt JA, Hunter DJ, Fuchs CS. MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. Carcinogenesis 2007 Jul 9;
  PMID: 17621591
• Chan AT, Ogino S, Fuchs CS. Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of COX-2. N Engl J Med 2007 May 24; 356(21):2131-2142
  PMID: 17522398
• Ogino S, Kawasaki T, Kirkner GJ, Kraft P, Loda M, Fuchs CS. Evaluation of Markers for CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer by a Large Population-Based Sample. J Mol Diagn 2007 May 3;
  PMID: 17478565
• Ogino S, Kawasaki T, Kirkner G, Ogawa A, Dorfman I, Loda M, Fuchs C. Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer. J Pathol 2006 Jul 19;
  PMID: 16850502
• Koushik A, Tranah GJ, Ma J, Stampfer MJ, Sesso HD, Fuchs CS, Giovannucci EL, Hunter DJ. p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer. Int J Cancer 2006 May 23;
  PMID: 16721787
• Fuchs CS, Giovannucci EL, Colditz GA, Hunter DJ, Stampfer MJ, Rosner B, Speizer FE, Willett WC. Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med 1999 Jan 21; 340(3):169-76
  PMID: 9895396
• Fuchs CS, Colditz GA, Stampfer MJ, Giovannucci EL, Hunter DJ, Rimm EB, Willett WC, Speizer FE. A prospective study of cigarette smoking and the risk of pancreatic cancer. Arch Intern Med 1996 Oct 28; 156(19):2255-60
  PMID: 8885826
• Fuchs CS, Giovannucci EL, Colditz GA, Hunter DJ, Speizer FE, Willett WC. A prospective study of family history and the risk of colorectal cancer. N Engl J Med 1994 Dec 22; 331(25):1669-74
  PMID: 7969357