DF/HCC Program Affiliation

Leader, Biostatistics Program
Member, Neuro-Oncology Program

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

Dr. Betensky's research is currently focused on the development of new methods of the analysis of multi-dimensional clustered binary data and interval censored data. She has applied these methods to physician recommendations for early prostate cancer treatment, a designed experiment of an immunologic assay, AIDS clincal trials, and family studies of multiple diseases.

Publications

• Matthews AG, Finkelstein DM, Betensky RA. Multivariate logistic regression for familial aggregation in age at disease onset. Lifetime Data Analysis 2007 Jun; 13(2):191-209
  PMID: 17410428
• Cahill DP, Levine KK, Betensky RA, Codd PJ, Romany CA, Reavie LB, Batchelor TT, Futreal PA, Stratton MR, Curry WT, Iafrate AJ, Louis DN. Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. Clin Cancer Res 2007 Apr 1; 13(7):2038-45
  PMID: 17404084
• Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci 2007 Feb 21; 27(8):1973-80
  PMID: 17314293
• Houseman EA, Coull BA, Betensky RA. Feature-specific penalized latent class analysis for genomic data. Biometrics 2006 Dec; 62(4):1062-70
  PMID: 17156280
• Rousseau A, Nutt CL, Betensky RA, Iafrate AJ, Han M, Ligon KL, Rowitch DH, Louis DN. Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2. J Neuropathol Exp Neurol 2006 Dec; 65(12):1149-56
  PMID: 17146289
• Mizoguchi M, Betensky RA, Batchelor TT, Bernay DC, Louis DN, Nutt CL. Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival. J Neuropathol Exp Neurol 2006 Dec; 65(12):1181-8
  PMID: 17146292
• Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis 2006 Dec; 24(3):516-24
  PMID: 17029828
• Baehring JM, Hochberg FH, Betensky RA, Longtine J, Sklar J. Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes. J Neurol Sci 2006 Jun 7;
  PMID: 16764890
• Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN. AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer Res 2006 Jun 1; 66(11):5618-23
  PMID: 16740698
• Mohapatra G, Betensky RA, Miller ER, Carey B, Gaumont LD, Engler DA, Louis DN. Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization. J Mol Diagn 2006 May; 8(2):268-76
  PMID: 16645215
• Engler DA, Mohapatra G, Louis DN, Betensky RA. A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations. Biostatistics 2006 Jul; 7(3):399-421
  PMID: 16401686
• Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci 2006 Jan 11; 26(2):365-71
  PMID: 16407531
• Dong S, Nutt CL, Betensky RA, Stemmer-Rachamimov AO, Denko NC, Ligon KL, Rowitch DH, Louis DN. Histology-Based Expression Profiling Yields Novel Prognostic Markers in Human Glioblastoma. J Neuropathol Exp Neurol 2005 Nov; 64(11):948-955
  PMID: 16254489
• Riemenschneider MJ, Mueller W, Betensky RA, Mohapatra G, Louis DN. In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation. Am J Pathol 2005 Nov; 167(5):1379-87
  PMID: 16251422
• Cantuti-Castelvetri I, Lin MT, Zheng K, Keller-McGandy CE, Betensky RA, Johns DR, Beal MF, Standaert DG, Simon DK. Somatic mitochondrial DNA mutations in single neurons and glia. Neurobiol Aging 2005 Nov-Dec; 26(10):1343-55
  PMID: 16243605
• Shih HA, Betensky RA, Dorfman MV, Louis DN, Loeffler JS, Batchelor TT. Genetic analyses for predictors of radiation response in glioblastoma. Int J Radiat Oncol Biol Phys 2005 Nov 1; 63(3):704-10
  PMID: 15978739
• Betensky RA, Nutt CL, Batchelor TT, Louis DN. Statistical considerations for immunohistochemistry panel development after gene expression profiling of human cancers. J Mol Diagn 2005 May; 7(2):276-82
  PMID: 15858152
• Nutt CL, Betensky RA, Brower MA, Batchelor TT, Louis DN, Stemmer-Rachamimov AO. YKL-40 is a differential diagnostic marker for histologic subtypes of high-grade gliomas. Clin Cancer Res 2005 Mar 15; 11(6):2258-64
  PMID: 15788675