DF/HCC Program Affiliation

Member, Cancer Genetics Program
Member, Cancer Cell Biology Program
Member, Breast Cancer Program

DF/HCC Associations

Member, Clinical Science Coordinating Committee
Deputy Director, Dana-Farber/Harvard Cancer Center, Executive Committee
Principal Investigator, Technology Innovation Fund
Member, Center Scientific Council

Research Abstract

My research program is aimed at understanding the functional properties of four sets of nuclear proteins, each of which plays a major role in the suppression by human cells of certain transformed/neoplastic characteristics. They are the pocket protein family (pRB, p107, p130); p300 and CBP; p400 and TRRAP; and BRCA1 and 2. Analysis of the functions of BRCA1 and 2 as breast/ovarian cancer suppressing elements serve as our link to the Breast Cancer Program, and the work on the other three sets of transformation suppressing proteins underlie our participation in the Cancer Cell Biology Program. Futhermore, our laboratory contributes to an ongoing nodal point interaction between these two Programs. We are also working on converting elements of recent discovery of p300/CBP function into new screens for small molecule agents that interfere with hypoxia-driven tumor survival/proliferation responses.

Publications

• Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA. RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science 2007 May 25; 316(5828):1198-202
  PMID: 17525341
• Tischkowitz M, Xia B, Sabbaghian N, Reis-Filho JS, Hamel N, Li G, van Beers EH, Li L, Khalil T, Quenneville LA, Omeroglu A, Poll A, Lepage P, Wong N, Nederlof PM, Ashworth A, Tonin PN, Narod SA, Livingston DM, Foulkes WD. Analysis of PALB2/FANCN-associated breast cancer families. Proc Natl Acad Sci U S A 2007 Apr 17; 104(16):6788-93
  PMID: 17420451
• Silver DP, Dimitrov SD, Feunteun J, Gelman R, Drapkin R, Lu SD, Shestakova E, Velmurugan S, Denunzio N, Dragomir S, Mar J, Liu X, Rottenberg S, Jonkers J, Ganesan S, Livingston DM. Further evidence for BRCA1 communication with the inactive X chromosome. Cell 2007 Mar 9; 128(5):991-1002
  PMID: 17350581
• Erkko H, Xia B, Nikkilä J, Schleutker J, Syrjäkoski K, Mannermaa A, Kallioniemi A, Pylkäs K, Karppinen SM, Rapakko K, Miron A, Sheng Q, Li G, Mattila H, Bell DW, Haber DA, Grip M, Reiman M, Jukkola-Vuorinen A, Mustonen A, Kere J, Aaltonen LA, Kosma VM, Ka. A recurrent mutation in PALB2 in Finnish cancer families. Nature 2007 Mar 15; 446(7133):316-9
  PMID: 17287723
• Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM. The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell 2006 Nov 3; 127(3):539-52
  PMID: 17081976
• Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, Livingston DM. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell 2006 Jun 23; 22(6):719-29
  PMID: 16793542
• Kim H, Livingston DM. A high mobility group protein binds to long CAG repeat tracts and establishes their chromatin organization in Saccharomyces cerevisiae. J Biol Chem 2006 Apr 9;
  PMID: 16603770
• Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell 2006 Feb; 9(2):121-32
  PMID: 16473279
• Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM. Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev 2006 Jan 1; 20(1):34-46
  PMID: 16391231
• Muljo SA, Ansel KM, Kanellopoulou C, Livingston DM, Rao A, Rajewsky K. Aberrant T cell differentiation in the absence of Dicer. J Exp Med 2005 Jul 18; 202(2):261-9
  PMID: 16009718
• Elshamy WM, Livingston DM. Promoter usage of BRCA1-IRIS. Nat Cell Biol 2005 Apr; 7(4):326
  PMID: 15803127
• Samuelson AV, Narita M, Chan HM, Jin J, de Stanchina E, McCurrach ME, Narita M, Fuchs M, Livingston DM, Lowe SW. p400 is required for E1A to promote apoptosis. J Biol Chem 2005 Jun 10; 280(23):21915-23
  PMID: 15741165
• Kanellopoulou C, Muljo SA, Kung AL, Ganesan S, Drapkin R, Jenuwein T, Livingston DM, Rajewsky K. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev 2005 Feb 15; 19(4):489-501
  PMID: 15713842
• Chan HM, Narita M, Lowe SW, Livingston DM. The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. Genes Dev 2005 Jan 15; 19(2):196-201
  PMID: 15655109
• ElShamy WM, Livingston DM. Identification of BRCA1-IRIS, a BRCA1 locus product. Nat Cell Biol 2004 Oct; 6(10):954-67
  PMID: 15448696
• Taubert S, Gorrini C, Frank SR, Parisi T, Fuchs M, Chan HM, Livingston DM, Amati B. E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. Mol Cell Biol 2004 May; 24(10):4546-56
  PMID: 15121871
• Wilson CA, Ramos L, Villaseñor MR, Anders KH, Press MF, Clarke K, Karlan B, Chen JJ, Scully R, Livingston D, Zuch RH, Kanter MH, Cohen S, Calzone FJ, Slamon DJ. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 1999 Feb; 21(2):236-40
  PMID: 9988281
• Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G, Couch FJ, Weber BL, Ashley T, Livingston DM, Scully R. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 1998 Sep; 2(3):317-28
  PMID: 9774970