Ralph Weissleder M.D. Ph.D.
Professor, Department of Radiology, Harvard Medical School
Director, Center for Molecular Imaging Research, Massachusetts General Hospital
Contact Info
Ralph Weissleder
Massachusetts General Hospital
Building 149, 13th Street
Charlestown, MA, 02129
Mailstop: Room 5406
Phone: 6177268226
Fax: 6177265708
weissleder@helix.mgh.harvard.edu
Phone: 6177268226
Fax: 6177265700
moschell@helix.mgh.harvard.edu
Massachusetts General Hospital
Building 149, 13th Street
Charlestown, MA, 02129
Mailstop: Room 5406
Phone: 6177268226
Fax: 6177265708
weissleder@helix.mgh.harvard.edu
Assistant
Dianne MoschellaPhone: 6177268226
Fax: 6177265700
moschell@helix.mgh.harvard.edu
DF/HCC Program Affiliation
Leader, Cancer Imaging ProgramMember, Prostate Cancer Program
Member, Neuro-Oncology Program
Member, Gastrointestinal Malignancies Program
DF/HCC Associations
Principal Investigator, Molecular ImagingMember, Center Scientific Council
Research Abstract
Molecular Imaging researchPublications
- Kock N, Kasmieh R, Weissleder R, Shah K. Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL. Neoplasia 2007 May; 9(5):435-42
PMID: 17534449 - Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T. Restoration of p53 function leads to tumour regression in vivo. Nature 2007 Feb 8; 445(7128):661-5
PMID: 17251932 - Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D. Neural stem cell transplant survival in brains of mice: assessing the effect of immunity and ischemia by using real-time bioluminescent imaging. Radiology 2006 Dec; 241(3):822-30
PMID: 17114629 - Lamfers ML, Fulci G, Gianni D, Tang Y, Kurozumi K, Kaur B, Moeniralm S, Saeki Y, Carette JE, Weissleder R, Vandertop WP, van Beusechem VW, Dirven CM, Chiocca EA. Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther 2006 Dec; 14(6):779-88
PMID: 16996314 - Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA, Sheikov N. Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery. J Neurosurg 2006 Sep; 105(3):445-54
PMID: 16961141 - Fulci G, Breymann L, Gianni D, Kurozomi K, Rhee SS, Yu J, Kaur B, Louis DN, Weissleder R, Caligiuri MA, Chiocca EA. Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A 2006 Aug 22; 103(34):12873-8
PMID: 16908838 - Chen JW, Querol Sans M, Bogdanov A, Weissleder R. Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology 2006 Aug; 240(2):473-81
PMID: 16864673 - Galande AK, Hilderbrand SA, Weissleder R, Tung CH. Enzyme-targeted fluorescent imaging probes on a multiple antigenic Peptide core. J Med Chem 2006 Jul 27; 49(15):4715-20
PMID: 16854078 - Choi Y, Weissleder R, Tung CH. Selective antitumor effect of novel protease-mediated photodynamic agent. Cancer Res 2006 Jul 15; 66(14):7225-9
PMID: 16849570 - Montet X, Weissleder R, Josephson L. Imaging pancreatic cancer with a Peptide-nanoparticle conjugate targeted to normal pancreas. Bioconjug Chem 2006 Jul-Aug; 17(4):905-11
PMID: 16848396 - Hsiao JK, Law B, Weissleder R, Tung CH. In-vivo imaging of tumor associated urokinase-type plasminogen activator activity. J Biomed Opt 2006 May-Jun; 11(3):34013
PMID: 16822063 - Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R. Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A 2006 Jul 5; 103(27):10340-5
PMID: 16801531 - Kelly KA, Clemons PA, Yu AM, Weissleder R. High-throughput identification of phage-derived imaging agents. Mol Imaging 2006 Jan-Mar; 5(1):24-30
PMID: 16779967 - Tréhin R, Figueiredo JL, Pittet MJ, Weissleder R, Josephson L, Mahmood U. Fluorescent nanoparticle uptake for brain tumor visualization. Neoplasia 2006 Apr; 8(4):302-11
PMID: 16756722 - Weissleder R. Molecular imaging in cancer. Science 2006 May 26; 312(5777):1168-71
PMID: 16728630 - Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK. N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption. Mol Cell Biol 2006 Jun; 26(11):4185-200
PMID: 16705170 - Tannous BA, Grimm J, Perry KF, Chen JW, Weissleder R, Breakefield XO. Metabolic biotinylation of cell surface receptors for in vivo imaging. Nat Methods 2006 May; 3(5):391-6
PMID: 16628210 - Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L. Nanoparticle imaging of integrins on tumor cells. Neoplasia 2006 Mar; 8(3):214-22
PMID: 16611415 - Law B, Weissleder R, Tung CH. Peptide-based biomaterials for protease-enhanced drug delivery. Biomacromolecules 2006 Apr; 7(4):1261-5
PMID: 16602747 - Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 2006 May; 12(5):797-806
PMID: 16556935 - Quinti L, Weissleder R, Tung CH. A fluorescent nanosensor for apoptotic cells. Nano Lett 2006 Mar; 6(3):488-90
PMID: 16522048 - Rabin O, Manuel Perez J, Grimm J, Wojtkiewicz G, Weissleder R. An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat Mater 2006 Feb; 5(2):118-22
PMID: 16444262 - Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X. Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery. Hum Gene Ther 2005 Dec; 16(12):1367-76
PMID: 16390268 - McCarthy JR, Perez JM, Brückner C, Weissleder R. Polymeric nanoparticle preparation that eradicates tumors. Nano Lett 2005 Dec; 5(12):2552-6
PMID: 16351214 - Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V. Volumetric tomography of fluorescent proteins through small animals in vivo. Proc Natl Acad Sci U S A 2005 Dec 20; 102(51):18252-7
PMID: 16344470 - Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R. Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology 2002 Feb; 122(2):406-14
PMID: 11832455 - Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP. In vivo magnetic resonance imaging of transgene expression. Nat Med 2000 Mar; 6(3):351-5
PMID: 10700241 - Weissleder R, Tung CH, Mahmood U, Bogdanov A. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999 Apr; 17(4):375-8
PMID: 10207887 - Josephson L, Tung CH, Moore A, Weissleder R. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjug Chem 1999 Mar-Apr; 10(2):186-91
PMID: 10077466 - Moore A, Basilion JP, Chiocca EA, Weissleder R. Measuring transferrin receptor gene expression by NMR imaging. Biochim Biophys Acta 1998 Apr 24; 1402(3):239-49
PMID: 9606982 - Zimmer C, Wright SC, Engelhardt RT, Johnson GA, Kramm C, Breakefield XO, Weissleder R. Tumor cell endocytosis imaging facilitates delineation of the glioma-brain interface. Exp Neurol 1997 Jan; 143(1):61-9
PMID: 9000446




