DF/HCC Program Affiliation

Member, Lymphoma and Myeloma Program
Member, Cancer Immunology Program

Research Abstract

My laboratory focus is on how the malignant microenvironment affects the growth and survival of B cell leukemias and lymphomas. This involves studies of supportive cells and the cell-cell contact and soluble factors which they provide for malignant B cells. In the area of clinical research, I have focused on the role of high dose therapy in indolent lymphomas and strategies to improve this treatment. This includes improvements in purging tumor cells from the normal hematopoietic stem cells and post-transplant therapies using immunotherapeutic approaches with cytokines and monoclonal antibodies.

Publications

• Astier A, Manié SN, Avraham H, Hirai H, Law SF, Zhang Y, Golemis EA, Fu Y, Druker BJ, Haghayeghi N, Freedman AS, Avraham S. The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1. J Biol Chem 1997 Aug 8; 272(32):19719-24
  PMID: 9242628