DF/HCC Program Affiliation

Member, Lung Cancer Program

Research Abstract

I am a member of the clinical research faculty at the Massachusets General Hospital Cancer Center and Harvard Medical School. I devote 75% of my time to clinical research, specifically developing and implementing clinical trials and translational correlative science studies under the guidance of my clinical mentor, Dr. Thomas Lynch and my scientific mentor, Dr. Daniel Haber. My work brings novel treatments for lung cancer to the clinic and also defines methods of tailoring therapeutic recommendations to individual patients with lung cancer. Currently, I am studying non-small cell lung cancer with somatic EGFR activating mutations, therapeutic agents that interact with the EGF receptor, the novel compound TLK286 in combination with standard chemotherapy for non-small cell lung cancer, the prognostic significance of circulating tumor cells in cancer patients, combination chemotherapy in elderly patients with non-small cell lung cancer, and functional assessment as a predictor of risk during chemotherapy in elderly patients.

Publications

• Oxnard GR, Fidias P, Muzikansky A, Sequist LV. Non-small cell lung cancer in octogenarians: treatment practices and preferences. J Thorac Oncol 2007 Nov; 2(11):1029-35
  PMID: 17975495
• Sequist LV, Lynch TJ. EGFR Tyrosine Kinase Inhibitors in Lung Cancer: An Evolving Story. Annu Rev Med 2007 Aug 20;
  PMID: 17716025
• Sequist LV, Joshi VA, Jänne PA, Bell DW, Fidias P, Lindeman NI, Louis DN, Lee JC, Mark EJ, Longtine J, Verlander P, Kucherlapati R, Meyerson M, Haber DA, Johnson BE, Lynch TJ. Epidermal growth factor receptor mutation testing in the care of lung cancer patients. Clin Cancer Res 2006 Jul 15; 12(14):4403s-8s
  PMID: 16857818
• Sequist LV, Haber DA, Lynch TJ. Epidermal growth factor receptor mutations in non-small cell lung cancer: predicting clinical response to kinase inhibitors. Clin Cancer Res 2005 Aug 15; 11(16):5668-70
  PMID: 16115901
• Sequist LV, Fidias P. Treatment of advanced non-small cell lung cancer in the elderly. Semin Respir Crit Care Med 2005 Jun; 26(3):289-97
  PMID: 16052430