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Rohit Kulkarni, MD, PhD

Associate Professor, Department of Medicine, Harvard Medical School

Senior Investigator, Section of Islet Cell & Regenerative Medicine , Joslin Diabetes Center

Contact Info

Rohit Kulkarni
Joslin Diabetes Center
Room 410

Boston, MA, 02215
Phone: 617-309-3460
Fax: 617-306-3476
rohit.kulkarni@joslin.harvard.edu

Assistant

Jane Hu
Lab Manager
Section of Islet Cell & Regenerative Medicine
Joslin Diabetes Center
One Joslin Place
Boston, MA, 02215
Phone: 617-309-4429
jiang.hu@joslin.harvard.edu
Patti Muehter
Administrative Assistant
Section of Islet Cell & Regenerative Medicine
Joslin Diabetes Center
One Joslin Place
Boston, MA, 02215
Phone: 617-309-4024
Fax: 617-309-2629
patti.muehter@joslin.harvard.edu

DF/HCC Program Affiliation

Cancer Immunology

Lab Website

Kulkarni Lab

Research Abstract

The focus of the Kulkarni lab relates to understanding the signaling patwhays that promote growth and proliferation of islet cells. The lab has an interest in molecules that link growth factor signaling with proteins and pathways that also modulate tumor and uncontrolled proliferation. For example, p53 is a transcription factor which is the most frequently altered gene in human cancer. Mice deficient for p53 are developmentally normal but suceptible to spontaneous tumours. p53 is a cellular stress sensor leading to cell-cycle arrest, DNA repair, cellular senescence and apoptosis. We study the coordination and communication between the Insulin/IGF-1 and p53 signaling pathways in pancreatic islet growth. We are also intersted in the relevance of leptin signaling in the regulation of patheays that promote enhanced proliferation of progenitors in the adipocyte and endocrine lineages. We are undertaking studies to examine how mutations in the leptin receptor can modluate the ability of induced pluripotent stem cells to prolferate and differentiate towards different cell types.

Publications

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