DF/HCC Program Affiliation

Sarcoma
Gastrointestinal Malignancies

Research Abstract

My major research interests are soft tissue sarcomas and gastrointestinal cancers. My focus in soft tissue sarcomas includes evaluating histologic and immunohistochemical parameters that predict clinical outcome, and identifying diagnostically useful immunophenotypic markers. The sarcomas I currently study include gastrointestinal stromal tumors (GIST), leiomyosarcomas, histiocytic and dendritic cell sarcomas, and neural tumors of skin and soft tissue. My focus in gastrointestinal cancer is the pathology of Barrett’s esophagus and associated dysplasia and adenocarcinoma, in particular with the goal of improving the prognostic value of endoscopic surveillance biopsies, and studying the clonal evolution of neoplasia in Barrett’s esophagus. In addition to esophageal adenocarcinoma, I also study colorectal carcinoma and pancreatic carcinoma.

Publications

• Hornick JL, Fletcher CD.The role of KIT in the management of patients with gastrointestinal stromal tumors.Hum Pathol 2007 May;38(5):679-87.
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• Srivastava A, Hornick JL, Li X, Blount PL, Sanchez CA, Cowan DS, Ayub K, Maley CC, Reid BJ, Odze RD.Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus.Am J Gastroenterol 2007 Mar;102(3):4
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• Hornick JL, Fletcher CD.PEComa: what do we know so far?.Histopathology 2006 Jan;48(1):75-82.
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• Hornick JL, Fletcher CD.Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features.Am J Surg Pathol 2005 Jul;29(7):845-58.
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• Hornick JL, Blount PL, Sanchez CA, Cowan DS, Ayub K, Maley CC, Reid BJ, Odze RD.Biologic properties of columnar epithelium underneath reepithelialized squamous mucosa in Barrett's esophagus.Am J Surg Pathol 2005 Mar;29(3):372-80.
  15725807
• Hornick JL, Bosenberg MW, Mentzel T, McMenamin ME, Oliveira AM, Fletcher CD.Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases.Am J Surg Pathol 2004 Oct;28(10):1257-67.
  15371941
• Hornick JL, Fletcher CD.Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters.Am J Surg Pathol 2003 Sep;27(9):1183-96.
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• Hornick JL, Fletcher CD.Immunohistochemical staining for KIT (CD117) in soft tissue sarcomas is very limited in distribution.Am J Clin Pathol 2002 Feb;117(2):188-93.
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