DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

The laboratory is interested in the humoral immune response to cancer including prostate cancer and breast cancer. Human monoclonal antibodies to prostate and breast cancer are developed to study and develop passive and active immunotherapy. The laboratory is also interested in the humoral immune response in viral oncology and with EBV and HHV-8 in particular. Again, analysis of the antibody response will lead to a better understanding of the interactions of the immune system with these cancers and the design of effective active and passive immunotherapy.

Publications

• Cavacini L, Posner M.Native HIV type 1 virion surface structures: relationships between antibody binding and neutralization or lessons from the viral capture assay.AIDS Res Hum Retroviruses 2004 Apr;20(4):435-41.
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• Liu F, Bergami PL, Duval M, Kuhrt D, Posner M, Cavacini L.Expression and functional activity of isotype and subclass switched human monoclonal antibody reactive with the base of the V3 loop of HIV-1 gp120.AIDS Res Hum Retroviruses 2003 Jul;19(7):597-607.
  12908937
• Cavacini LA, Duval M, Eder JP, Posner MR.Evidence of determinant spreading in the antibody responses to prostate cell surface antigens in patients immunized with prostate-specific antigen.Clin Cancer Res 2002 Feb;8(2):368-73.
  11839651