Frank C. Kuo, M.D. Ph.D.
Assistant Professor, Department of Pathology, Harvard Medical School
Assistant Medical Director, Clinical Hematology, Brigham And Women's Hospital
Contact Info
Frank Kuo
Brigham And Women's Hospital
75 Francis Street
Boston, MA, 02115
Mailstop: Thorn Bldg, Rm 603
Phone: 857-307-1534
Fax: 617-732-7449
FKUO@PARTNERS.ORG
Brigham And Women's Hospital
75 Francis Street
Boston, MA, 02115
Mailstop: Thorn Bldg, Rm 603
Phone: 857-307-1534
Fax: 617-732-7449
FKUO@PARTNERS.ORG
Assistant
Not Available.DF/HCC Associations
Director, Pathology Specimen LocatorMember, Center Scientific Council
Pathologist, Specialized HistoPathology
Research Abstract
The laboratory studies the mechanism of mutagen-induced mutagenesis and its role in cancer formation. Specifically, we have cloned several human genes involved in translesional DNA synthesis and repair of mutagen-damaged DNA. Using biochemical and genetic tools, we are in the process of characterizing the functions of these genes and their importance in mutagenesis. Modulation of functions of these genes may help to prevent mutations and cancer.Publications
- Wang LC, Swat W, Fujiwara Y, Davidson L, Visvader J, Kuo F, Alt FW, Gilliland DG, Golub TR, Orkin SH.The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow.Genes Dev 1998 Aug 1;12(15):2392-402.
9694803 - Kuo FC, Sklar J.Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers.J Exp Med 1997 Nov 3;186(9):1547-56.
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