DF/HCC Program Affiliation

Gynecologic Cancer

DF/HCC Associations

BIDMC, Sarcoma, Clinical Trial Chairs

Research Abstract

My research focus is on the application of high throughput technologies such as genomics and proteomics in cancer clinical investigation. Goals are to discover and developt transrciption or proteomic signatures in various human tissues strongly associated with cancer risk, progression, response to treatment and overall outcome. Major tools in the laboratory are (among others) expression microarrays, high throughput real time PCR, and mass spetrometry. Molecular profiling data are linked to extensively annotated clinical cancer databases and results are generated through intense biostatistics and bioinformatics analysis. Major focus in ovarian cancer although parellel projects in other tumors are also ongoing.

Publications

• Spentzos D, Levine DA, Kolia S, Otu H, Boyd J, Libermann TA, Cannistra SA.Unique gene expression profile based on pathologic response in epithelial ovarian cancer.J Clin Oncol 2005 Nov 1;23(31):7911-8.
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• Jones J, Otu H, Spentzos D, Kolia S, Inan M, Beecken WD, Fellbaum C, Gu X, Joseph M, Pantuck AJ, Jonas D, Libermann TA.Gene signatures of progression and metastasis in renal cell cancer.Clin Cancer Res 2005 Aug 15;11(16):5730-9.
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• Aivado M, Spentzos D, Alterovitz G, Otu HH, Grall F, Giagounidis AA, Wells M, Cho JY, Germing U, Czibere A, Prall WC, Porter C, Ramoni MF, Libermann TA.Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectro
  15843205
• Spentzos D, Levine DA, Ramoni MF, Joseph M, Gu X, Boyd J, Libermann TA, Cannistra SA.Gene expression signature with independent prognostic significance in epithelial ovarian cancer.J Clin Oncol 2004 Dec 1;22(23):4648-58.
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