DF/HCC Program Affiliation

Cancer Imaging
Prostate Cancer

Research Abstract

My research focus is on the development of novel algorithms that improve our capability to extract information from images and to apply that information for the treatment of cancer. The applications of this technology include:
1. improved targeting and monitoring for brain tumor surgeries and prostate cancer treatment
2. preoperative surgical planning
3. assessment of tumor volume and infiltration by 3D segmentation of multimodality imaging data
4. nonrigid registration for multimodality image fusion

Publications

• Archip N, Clatz O, Whalen S, Kacher D, Fedorov A, Kot A, Chrisochoides N, Jolesz F, Golby A, Black PM, Warfield SK.Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guide
  17289403
• Dimaio SP, Archip N, Hata N, Talos IF, Warfield SK, Majumdar A, Mcdannold N, Hynynen K, Morrison PR, Wells WM, Kacher DF, Ellis RE, Golby AJ, Black PM, Jolesz FA, Kikinis R.Image-guided neurosurgery at Brigham and Women's Hospital.IEEE Eng Med Biol Mag 20
  17020201
• Warfield SK, Zou KH, Wells WM.Simultaneous truth and performance level estimation (STAPLE): an algorithm for the validation of image segmentation.IEEE Trans Med Imaging 2004 Jul;23(7):903-21.
  15250643
• Grau V, Mewes AU, Alcañiz M, Kikinis R, Warfield SK.Improved watershed transform for medical image segmentation using prior information.IEEE Trans Med Imaging 2004 Apr;23(4):447-58.
  15084070
• Zou KH, Wells WM, Kikinis R, Warfield SK.Three validation metrics for automated probabilistic image segmentation of brain tumours.Stat Med 2004 Apr 30;23(8):1259-82.
  15083482
• Als H, Duffy FH, McAnulty GB, Rivkin MJ, Vajapeyam S, Mulkern RV, Warfield SK, Huppi PS, Butler SC, Conneman N, Fischer C, Eichenwald EC.Early experience alters brain function and structure.Pediatrics 2004 Apr;113(4):846-57.
  15060237
• Jaume S, Ferrant M, Macq B, Hoyte L, Fielding JR, Schreyer A, Kikinis R, Warfield SK.Tumor detection in the bladder wall with a measurement of abnormal thickness in CT scans.IEEE Trans Biomed Eng 2003 Mar;50(3):383-90.
  12669995
• Ferrant M, Nabavi A, Macq B, Black PM, Jolesz FA, Kikinis R, Warfield SK.Serial registration of intraoperative MR images of the brain.Med Image Anal 2002 Dec;6(4):337-59.
  12426109
• Hirose M, Bharatha A, Hata N, Zou KH, Warfield SK, Cormack RA, D'Amico A, Kikinis R, Jolesz FA, Tempany CM.Quantitative MR imaging assessment of prostate gland deformation before and during MR imaging-guided brachytherapy.Acad Radiol 2002 Aug;9(8):906-12.
  12186439
• Ruiz-Alzola J, Westin CF, Warfield SK, Alberola C, Maier S, Kikinis R.Nonrigid registration of 3D tensor medical data.Med Image Anal 2002 Jun;6(2):143-61.
  12045001
• Wei X, Warfield SK, Zou KH, Wu Y, Li X, Guimond A, Mugler JP, Benson RR, Wolfson L, Weiner HL, Guttmann CR.Quantitative analysis of MRI signal abnormalities of brain white matter with high reproducibility and accuracy.J Magn Reson Imaging 2002 Feb;15(2):2
  11836778
• Ferrant M, Nabavi A, Macq B, Jolesz FA, Kikinis R, Warfield SK.Registration of 3-D intraoperative MR images of the brain using a finite-element biomechanical model.IEEE Trans Med Imaging 2001 Dec;20(12):1384-97.
  11811838
• Bharatha A, Hirose M, Hata N, Warfield SK, Ferrant M, Zou KH, Suarez-Santana E, Ruiz-Alzola J, D'Amico A, Cormack RA, Kikinis R, Jolesz FA, Tempany CM.Evaluation of three-dimensional finite element-based deformable registration of pre- and intraoperative
  11797960
• Benson RR, Guttmann CR, Wei X, Warfield SK, Hall C, Schmidt JA, Kikinis R, Wolfson LI.Older people with impaired mobility have specific loci of periventricular abnormality on MRI.Neurology 2002 Jan 8;58(1):48-55.
  11781405
• Nabavi A, Black PM, Gering DT, Westin CF, Mehta V, Pergolizzi RS, Ferrant M, Warfield SK, Hata N, Schwartz RB, Wells WM, Kikinis R, Jolesz FA.Serial intraoperative magnetic resonance imaging of brain shift.Neurosurgery 2001 Apr;48(4):787-97; discussion 79
  11322439
• Kaus MR, Warfield SK, Nabavi A, Black PM, Jolesz FA, Kikinis R.Automated segmentation of MR images of brain tumors.Radiology 2001 Feb;218(2):586-91.
  11161183
• Warfield SK, Kaus M, Jolesz FA, Kikinis R.Adaptive, template moderated, spatially varying statistical classification.Ultrasound Med Biol 2000 Mar;4(1):43-55.
  10972320
• Schreyer AG, Fielding JR, Warfield SK, Lee JH, Loughlin KR, Dumanli H, Jolesz FA, Kikinis R.Virtual CT cystoscopy: color mapping of bladder wall thickness.Invest Radiol 2000 May;35(5):331-4.
  10803675