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Bruce M. Spiegelman, PhD

Stanley J. Korsmeyer Professor of Cell Biology and Medicine, Department of Cell Biology, Harvard Medical School

Stanley J. Korsmeyer Professor of Cell Biology and Medicine, Department of Medicine, Harvard Medical School

Professor, Cancer Biology, Dana-Farber Cancer Institute

Contact Info

Bruce Spiegelman
Dana-Farber Cancer Institute
450 Brookline Avenue CLSB 11-145
Boston, MA, 02215
Mailstop: CLS11146
Phone: 617-632-3567
Fax: 617-632-5363
bruce_spiegelman@dfci.harvard.edu

Assistant

Jollanda Lako
Group Administrator
Cancer Biology
Dana-Farber Cancer Institute
450 Brookline Ave, CLSB 11-146
Boston, MA, 02215
Mailstop: CLS11146
Phone: 617-582-7176
Fax: 617-632-5363
Jollanda_Lako@dfci.harvard.edu

DF/HCC Program Affiliation

Sarcoma
Prostate Cancer
Cancer Cell Biology

Research Abstract

We are interested in the regulation of cell differentiation and pathways of differentiation that can be used to force the maturation of human tumors. We have described the fucntion of a novel nuclear receptor, PPARgamma, that controls the differentiation of adipose cells. This transcription factor is also the functioning receptor of the thiazolidinedione (TZD) class of anti-diabetes drugs. Ligand activation of PPARgamma also derived from breast, prostate and colon. Our research is focused on pathways of differentiation induced by activation of PPARgamma in normal and malignant cells. In addition, we are interested in mutations acquired in the PPARgamma pathways during tumorigenesis.

Publications

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