Bruce M. Spiegelman, PhD

Stanley J. Korsmeyer Professor of Cell Biology and Medicine, Department of Cell Biology, Harvard Medical School

Stanley J. Korsmeyer Professor of Cell Biology and Medicine, Department of Medicine, Harvard Medical School

Professor, Cancer Biology, Dana-Farber Cancer Institute

Contact Info

Bruce Spiegelman
Dana-Farber Cancer Institute
450 Brookline Avenue CLSB 11-145
Boston, MA, 02215
Mailstop: CLS11146
Phone: 617-632-3567
Fax: 617-632-5363
bruce_spiegelman@dfci.harvard.edu

Assistant

Jollanda Lako
Group Administrator
Cancer Biology
Dana-Farber Cancer Institute
450 Brookline Ave, CLSB 11-146
Boston, MA, 02215
Mailstop: CLS11146
Phone: 617-582-7176
Fax: 617-632-5363
Jollanda_Lako@dfci.harvard.edu

DF/HCC Program Affiliation

Sarcoma
Prostate Cancer
Cancer Cell Biology

Research Abstract

We are interested in the regulation of cell differentiation and pathways of differentiation that can be used to force the maturation of human tumors. We have described the fucntion of a novel nuclear receptor, PPARgamma, that controls the differentiation of adipose cells. This transcription factor is also the functioning receptor of the thiazolidinedione (TZD) class of anti-diabetes drugs. Ligand activation of PPARgamma also derived from breast, prostate and colon. Our research is focused on pathways of differentiation induced by activation of PPARgamma in normal and malignant cells. In addition, we are interested in mutations acquired in the PPARgamma pathways during tumorigenesis.

Publications

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DF/HCC Directory Login Update Member Profile Change Account Settings Applying for Membership Benefits Requirements Responsibilities	Bruce M. Spiegelman, PhD Stanley J. Korsmeyer Professor of Cell Biology and Medicine, Department of Cell Biology, Harvard Medical School Stanley J. Korsmeyer Professor of Cell Biology and Medicine, Department of Medicine, Harvard Medical School Professor, Cancer Biology, Dana-Farber Cancer Institute Contact Info Bruce Spiegelman Dana-Farber Cancer Institute 450 Brookline Avenue CLSB 11-145 Boston, MA, 02215 Mailstop: CLS11146 Phone: 617-632-3567 Fax: 617-632-5363 bruce_spiegelman@dfci.harvard.edu Assistant Jollanda Lako Group Administrator Cancer Biology Dana-Farber Cancer Institute 450 Brookline Ave, CLSB 11-146 Boston, MA, 02215 Mailstop: CLS11146 Phone: 617-582-7176 Fax: 617-632-5363 Jollanda_Lako@dfci.harvard.edu DF/HCC Program Affiliation Sarcoma Prostate Cancer Cancer Cell Biology Research Abstract We are interested in the regulation of cell differentiation and pathways of differentiation that can be used to force the maturation of human tumors. We have described the fucntion of a novel nuclear receptor, PPARgamma, that controls the differentiation of adipose cells. This transcription factor is also the functioning receptor of the thiazolidinedione (TZD) class of anti-diabetes drugs. Ligand activation of PPARgamma also derived from breast, prostate and colon. Our research is focused on pathways of differentiation induced by activation of PPARgamma in normal and malignant cells. In addition, we are interested in mutations acquired in the PPARgamma pathways during tumorigenesis. Publications View All Publications
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