DF/HCC Program Affiliation

Gastrointestinal Malignancies
Cancer Epidemiology

Research Abstract

My research focuses on prevention of colorectal cancer. First, I am pursuing epidemiological studies of colorectal adenoma and cancer with an emphasis in understanding the role of inflammation in promoting risk of neoplasia and in defining the role of aspirin and NSAIDs in chemoprevention. Second, I am investigating novel methods of colorectal neoplasia detection, including clinical use of molecularly based, immunofluorescent probes to enhance standard colonoscopy.

Publications

• Chan AT, Ogino S, Fuchs CS.Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of COX-2.N Engl J Med 2007 May 24;356(21):2131-2142.
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• Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Curhan GC, Fuchs CS.Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer.JAMA 2005 Aug 24;294(8):914-23.
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• Chan AT, Tranah GJ, Giovannucci EL, Hunter DJ, Fuchs CS.Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma.J Natl Cancer Inst 2005 Mar 16;97(6):457-60.
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• Chan AT, Giovannucci EL, Schernhammer ES, Colditz GA, Hunter DJ, Willett WC, Fuchs CS.A prospective study of aspirin use and the risk for colorectal adenoma.Ann Intern Med 2004 Feb 3;140(3):157-66.
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